PIWI proteins and piRNAs in cervical cancer: a propitious dart in cancer stem cell-targeted therapy

Kunnummal, Midhunaraj; Angelin, Mary; Das, Ani V.

doi:10.1007/s13577-021-00590-4

Cited by 8 publications

(4 citation statements)

References 83 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These RNAs mainly suppress the transposons and are involved in epigenetic inheritance. The aberrant expression of piRNAs was noted in many cancers such as colorectal, breast, ovarian, cervical, lung, prostate, hepatocellular, and renal cancers 35–37 . Unlike miRNAs and siRNAs, piRNAs do not have a stem‐loop structure 37 .…”

Section: Resultsmentioning

confidence: 99%

“…The aberrant expression of piRNAs was noted in many cancers such as colorectal, breast, ovarian, cervical, lung, prostate, hepatocellular, and renal cancers. [35][36][37] Unlike miRNAs and siRNAs, piRNAs do not have a stem-loop structure. 37 The uniqueness of piRNAs is that they possess 2′-O-methylation on the 3′ terminal ribose.…”

Section: Piwi Rnas (Pirnas)mentioning

confidence: 99%

“…[35][36][37] Unlike miRNAs and siRNAs, piRNAs do not have a stem-loop structure. 37 The uniqueness of piRNAs is that they possess 2′-O-methylation on the 3′ terminal ribose. The stability of piRNAs is attributed to 2′-O-methylation.…”

Section: Piwi Rnas (Pirnas)mentioning

confidence: 99%

See 2 more Smart Citations

Role of noncoding RNAs with emphasis on long noncoding RNAs as cervical cancer biomarkers

Sabeena¹

2023

Journal of Medical Virology

View full text Add to dashboard Cite

Cervical cancer is a significant public health problem in developing countries, as most cases present at an advanced stage. This review aimed to analyze the role of noncoding RNAs as diagnostic and prognostic biomarkers in cervical cancers. Published studies on specific microRNA signatures in body fluids and cervical cancer tissues are highly heterogeneous, and there are no validated assays. The precision of the various immune‐associated long noncoding (lncRNA) signatures should be assessed in clinical samples. Even though lncRNAs are tissue and cancer‐specific, safe and appropriate methods for delivery to tumor tissues, toxicities and side effects are to be explored. Few studies have evaluated deregulated lncRNA expression levels with clinicopathological factors in a limited number of clinical samples. Prospective studies assessing the diagnostic and prognostic roles of circulating lncRNAs and P‐Element‐induced wimpy testis interacting PIWI RNAs (Piwil RNAs) in cervical cancer cases are essential. For the clinical application of lnc‐RNA‐based biomarkers, comprehensive research is needed as the impact of noncoding transcripts on molecular pathways is complex. The standardization and validation of deregulated ncRNAs in noninvasive samples of cervical cancer cases are needed.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Piwi Rnas (Pirnas)mentioning

confidence: 99%

See 1 more Smart Citation

Role of noncoding RNAs with emphasis on long noncoding RNAs as cervical cancer biomarkers

Sabeena¹

2023

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…84 The target DNA sequences of piRNAs and PIWIs, on the other hand, are implicated in epigenetic alteration to render them transcriptionally inactive. 85 Gene imprinting, X chromosome inactivation, and TE silencing are all dependent on DNA methylation, one of the key epigenetic remodeling phenomena. 86 Mammalian germ cells will go through a special methylation reprogramming process that simultaneously creates a space for TE expression.…”

Section: Inhibition Of Transposable Elementsmentioning

confidence: 99%

Functions and mechanism of noncoding RNA in regulation and differentiation of male mammalian reproduction

Karoii

Azizi

2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

Noncoding RNAs (ncRNAs) are active regulators of a wide range of biological and physiological processes, including the majority of mammalian reproductive events. Knowledge of the biological activities of ncRNAs in the context of mammalian reproduction will allow for a more comprehensive and comparative understanding of male sterility and fertility. In this review, we describe recent advances in ncRNA‐mediated control of mammalian reproduction and emphasize the importance of ncRNAs in several aspects of mammalian reproduction, such as germ cell biogenesis and reproductive organ activity. Furthermore, we focus on gene expression regulatory feedback loops including hormones and ncRNA expression to better understand germ cell commitment and reproductive organ function. Finally, this study shows the role of ncRNAs in male reproductive failure and provides suggestions for further research.

show abstract

Regulation of Cervical Cancer Development by a Novel Circ_0000212/miR-1236-3p/GREM1 ceRNA Crosstalk

et al. 2023

View full text Add to dashboard Cite

PIWI proteins and piRNAs in cervical cancer: a propitious dart in cancer stem cell-targeted therapy

Cited by 8 publications

References 83 publications

Role of noncoding RNAs with emphasis on long noncoding RNAs as cervical cancer biomarkers

Role of noncoding RNAs with emphasis on long noncoding RNAs as cervical cancer biomarkers

Functions and mechanism of noncoding RNA in regulation and differentiation of male mammalian reproduction

Regulation of Cervical Cancer Development by a Novel Circ_0000212/miR-1236-3p/GREM1 ceRNA Crosstalk

Contact Info

Product

Resources

About