PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma

Chang, Zhengyan; Ji, Guo; Huang, Runzhi; Chen, Hong; Gao, Yaohui; Wang, Weifeng; Sun, Xuechen; Zhang, Jie; Zheng, Jiayi; Wei, Qing

doi:10.18632/aging.103206

Cited by 14 publications

(9 citation statements)

References 52 publications

(68 reference statements)

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“…16 Another study has revealed piR-13643 and piR-21238 could be novel diagnostic biomarkers for papillary thyroid carcinoma. 37 In addition, piR-10506469 were found to be significantly increased in the exosomes of plasma from both cholangiocarcinoma and gallbladder carcinoma patients, indicating it may be serve as the potential cancer biomarker. 38 Exosomes secreted from tumour cells may contain several piRNAs originated from cells, 39 which may be aberrantly expressed in tumour cells.…”

Section: Discussionmentioning

confidence: 98%

“…One recent study has showed that serum piR‐020619 and piR‐020450 are promising novel biomarkers for early detection of colorectal cancer 16 . Another study has revealed piR‐13643 and piR‐21238 could be novel diagnostic biomarkers for papillary thyroid carcinoma 37 . In addition, piR‐10506469 were found to be significantly increased in the exosomes of plasma from both cholangiocarcinoma and gallbladder carcinoma patients, indicating it may be serve as the potential cancer biomarker 38 .…”

Section: Discussionmentioning

confidence: 99%

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Circulating exosomal small RNAs are promising non‐invasive diagnostic biomarkers for gastric cancer

Zhang

et al. 2020

J Cellular Molecular Medi

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Gastric cancer (GC) is the fifth most common cancer worldwide and the third leading cause of death from malignant tumours. 1 In China, the number of people who were newly diagnosed with GC was approximately 679,100 and almost 498,000 people died in 2015. 2 As most newly diagnosed with GC are identified at an advanced stage, five-year survival rate of patients is low. 3 The most common-used GC tumour markers, including carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 199, CA242 and CA724, are not sensitive or specific enough for GC screening and diagnosis, particularly for the early GC patients. 4,5 Considering that the five-year survival rate of patients with early GC can reach to 90%, 6 there is an urgent need to develop more effective and simple diagnostic biomarkers for detection of early GC.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Circulating exosomal small RNAs are promising non‐invasive diagnostic biomarkers for gastric cancer

Zhang

et al. 2020

J Cellular Molecular Medi

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“… 14 , 16 Moreover, piR‐13643 and piR‐21238 have been identified, which may be promising diagnostic biomarkers for the accurate detection of papillary thyroid carcinoma. 32 However, the profile and potential as biomarkers of piRNAs in lung cancer remain largely undetermined.…”

Section: Discussionmentioning

confidence: 99%

PIWI‐interacting RNAs are aberrantly expressed and may serve as novel biomarkers for diagnosis of lung adenocarcinoma

Wang

Zhang

et al. 2021

Thoracic Cancer

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Background: Lung adenocarcinoma (LUAD) is the main subtype of primary lung cancer and is a leading cause of cancer-related death worldwide. PIWI-interacting RNAs (piRNAs) are a type of small non-coding RNAs that may play crucial roles in cancer progression and serve as biomarkers for tumor detection. This study aimed to explore the expression profiles and diagnostic values of piRNAs in LUAD. Methods: Small RNA sequencing was performed to investigate tissue piRNA profiles of LUAD. The expression of selected upregulated piRNAs were detected in tissues and serum exosome samples by quantitative real-time polymerase chain reaction (qRT-PCR). Serum exosomes were identified by transmission electron microscope, nanoparticle tracking analysis, and western blot analysis. Receiver operating characteristic (ROC) curve was adopted to quantify the diagnostic potentials of piRNAs in LUAD. Finally, a piRNA panel was developed by multivariate logistic regression model. Results: We identified that 76 piRNAs were overexpressed and 9 piRNAs were underexpressed in LUAD tissues compared with adjacent non-tumor tissues. Among the top 10 overexpressed piRNAs, 4 piRNAs (piR-hsa-26925, piR-hsa-5444, piR-hsa-30636, and piR-hsa-8757) were verified by qRT-PCR to be significantly upregulated in LUAD tissues. Moreover, piR-hsa-26925 and piR-hsa-5444 had a significantly higher level in serum exosome samples of LUAD patients than those of healthy controls. We finally established a 2-piRNA panel composed of piR-hsa-26925 and piR-hsa-5444, which showed higher diagnostic performance for LUAD with an AUC of 0.833. Conclusions: Our finding revealed the abnormally expressed piRNAs in LUAD, and serum exosomal piR-hsa-26925 and piR-hsa-5444 could serve as potential biomarkers for LUAD diagnosis.

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“…In NSCLC, piR-651 can induce tumor progression by affecting the cyclin D1 / CDK4 pathway and acts as a potential diagnostic indicator [ 11 , 12 ]. Using piRNA sequencing data from papillary thyroid carcinoma (PTC), researchers have identified two upregulated piRNAs, piR-13643 and piR-21238 and found that these two piRNAs are associated with clinical stages and exhibit better specificity for distinguishing between benign and malignant nodules than the current biomarker HBME1 [ 106 ].…”

Section: Pirnas As Diagnostic and Prognostic Biomarkers In Cancermentioning

confidence: 99%

The biogenesis and biological function of PIWI-interacting RNA in cancer

et al. 2021

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Small non-coding RNAs (ncRNAs) are vital regulators of biological activities, and aberrant levels of small ncRNAs are commonly found in precancerous lesions and cancer. PIWI-interacting RNAs (piRNAs) are a novel type of small ncRNA initially discovered in germ cells that have a specific length (24–31 nucleotides), bind to PIWI proteins, and show 2′-O-methyl modification at the 3′-end. Numerous studies have revealed that piRNAs can play important roles in tumorigenesis via multiple biological regulatory mechanisms, including silencing transcriptional and posttranscriptional gene processes and accelerating multiprotein interactions. piRNAs are emerging players in the malignant transformation of normal cells and participate in the regulation of cancer hallmarks. Most of the specific cancer hallmarks regulated by piRNAs are involved in sustaining proliferative signaling, resistance to cell death or apoptosis, and activation of invasion and metastasis. Additionally, piRNAs have been used as biomarkers for cancer diagnosis and prognosis and have great potential for clinical utility. However, research on the underlying mechanisms of piRNAs in cancer is limited. Here, we systematically reviewed recent advances in the biogenesis and biological functions of piRNAs and relevant bioinformatics databases with the aim of providing insights into cancer diagnosis and clinical applications. We also focused on some cancer hallmarks rarely reported to be related to piRNAs, which can promote in-depth research of piRNAs in molecular biology and facilitate their clinical translation into cancer treatment.

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PIWI-interacting RNAs piR-13643 and piR-21238 are promising diagnostic biomarkers of papillary thyroid carcinoma

Cited by 14 publications

References 52 publications

Circulating exosomal small RNAs are promising non‐invasive diagnostic biomarkers for gastric cancer

Circulating exosomal small RNAs are promising non‐invasive diagnostic biomarkers for gastric cancer

PIWI‐interacting RNAs are aberrantly expressed and may serve as novel biomarkers for diagnosis of lung adenocarcinoma

The biogenesis and biological function of PIWI-interacting RNA in cancer

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