2012
DOI: 10.1016/j.pdpdt.2011.12.004
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Pivotal roles of peptide transporter PEPT1 and ATP-binding cassette (ABC) transporter ABCG2 in 5-aminolevulinic acid (ALA)-based photocytotoxicity of gastric cancer cells in vitro

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Cited by 106 publications
(93 citation statements)
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“…6D). DISCUSSION ALA-induced PpIX accumulation has been reported to be affected by ALA influx into tumor cells (10,18). The present in vitro experiments, however, showed no correlation between 3 H-ALA radioactivity and PpIX accumulation in the tumor cells.…”
Section: Intratumoral Distribution Of 11 C-mala Alad Expression Andcontrasting
confidence: 70%
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“…6D). DISCUSSION ALA-induced PpIX accumulation has been reported to be affected by ALA influx into tumor cells (10,18). The present in vitro experiments, however, showed no correlation between 3 H-ALA radioactivity and PpIX accumulation in the tumor cells.…”
Section: Intratumoral Distribution Of 11 C-mala Alad Expression Andcontrasting
confidence: 70%
“…On the other hand, there are apparent differences in the accumulation of ALA-induced PpIX among tumors (8,9). These differences represent key factors influencing the therapeutic efficacy of ALA-based PDT/SDT (10,11). The precise assessment of PpIX accumulation in each tumor type can therefore play a significant role in predicting the therapeutic effects and selecting the appropriate patients who could potentially benefit from ALA-based PDT/SDT.…”
mentioning
confidence: 99%
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“…PEPT1 or PEPT2 (ALA influx transporter) in tumor cells and tissues (17,18). Therefore, the cytotoxic effects of ALA would only be evident in tumor cells.…”
Section: Discussionmentioning
confidence: 99%