Pivotal Role of Salicylates in Tuning the Formation and Reactivity of Mn(V)=O's

Abstract

An alternative and efficient route has been derived to generate the high valent [Mn(V)=O(m‐Cl‐salicylate)]+ intermediates with a series of non‐heme neutral ligand frameworks at 20 °C. The current method provides an advantage with feasibility in maintaining stoichiometric oxidant ratios along with the crucial variations of the salicylate moieties in tuning the reactivity of Mn(V)=O species. An indepth analysis of the Hammett studies revealed that the bound 5‐Xsalicylate (X = Cl, and NO2) drastically alters the corresponding Mn(V)=O’s reactivity rates. In contrast, variations in the parent ligand frameworks resulted in consistent ρ values with increased lifetimes depicting the ligand’s role in stabilization. Lastly, the complexes have been characterized to promote oxidative stress and prevent the proliferation of cancer cells effectively.