Pivotal Role of Peptides in Gastric Carcinoma: Diagnosis and Therapy

Ahmadpour, Sajjad; Khodadust, Fatemeh; Hormati, Ahmad; Eivaziatashbeik, Karim

doi:10.1007/s10989-020-10104-9

Cited by 2 publications

(1 citation statement)

References 217 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Collecting this observation, autophagic process is modulated via SIRT1 or other mediators that might play an essential role in tumor progression via modulating EMT as well as tumor cell invasion (Zia et al, 2021). Recently, it has been reported that autophagy encouraged the survival as well as invasive capability of SGC-7901 cells via facilitating the development of vasculogenic mimicry (Ahmadpour et al, 2021). Particularly, autophagy inhibition by beclin-1 silencing expression decreased cancer cell invasion and survival (Ding et al, 2014).…”

Section: Autophagy Markers Expressed In Gc Progressionmentioning

confidence: 99%

Potential Therapeutic Action of Autophagy in Gastric Cancer Managements: Novel Treatment Strategies and Pharmacological Interventions

et al. 2022

View full text Add to dashboard Cite

Gastric cancer (GC), second most leading cause of cancer-associated mortality globally, is the cancer of gastrointestinal tract in which malignant cells form in lining of the stomach, resulting in indigestion, pain, and stomach discomfort. Autophagy is an intracellular system in which misfolded, aggregated, and damaged proteins, as well as organelles, are degraded by the lysosomal pathway, and avoiding abnormal accumulation of huge quantities of harmful cellular constituents. However, the exact molecular mechanism of autophagy-mediated GC management has not been clearly elucidated. Here, we emphasized the role of autophagy in the modulation and development of GC transformation in addition to underlying the molecular mechanisms of autophagy-mediated regulation of GC. Accumulating evidences have revealed that targeting autophagy by small molecule activators or inhibitors has become one of the greatest auspicious approaches for GC managements. Particularly, it has been verified that phytochemicals play an important role in treatment as well as prevention of GC. However, use of combination therapies of autophagy modulators in order to overcome the drug resistance through GC treatment will provide novel opportunities to develop promising GC therapeutic approaches. In addition, investigations of the pathophysiological mechanism of GC with potential challenges are urgently needed, as well as limitations of the modulation of autophagy-mediated therapeutic strategies. Therefore, in this review, we would like to deliver an existing standard molecular treatment strategy focusing on the relationship between chemotherapeutic drugs and autophagy, which will help to improve the current treatments of GC patients.

show abstract

Section: Autophagy Markers Expressed In Gc Progressionmentioning

confidence: 99%