Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma

Atwa, Sara M; Handoussa, Heba; Hosny, Karim; Odenthal, Margarete; Tayebi, H.M. El

doi:10.4254/wjh.v12.i12.1211

Cited by 13 publications

(9 citation statements)

References 54 publications

(25 reference statements)

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“…On the immunological level, MALAT-1 knockdown in MDA-MB-231 cells resulted in an augmented increase in NK cells-mediated killing and CD8 + T cells-mediated cytotoxic activity against transfected TNBC cells. This goes in line with a recent study showing that knocking down of MALAT-1 in hepatocellular carcinoma cell lines resulted in a repression of PD-L1 expression [51] . However, our study was the first to show the modulatory role of MALAT-1 on NK cells immune ligands and B7-H4 in TNBC cells.…”

Section: Discussionsupporting

confidence: 90%

MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer

Mekky

Ragab²,

Manie

et al. 2023

Translational Oncology

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Section: Discussionsupporting

confidence: 90%

MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer

Mekky

Ragab²,

Manie

et al. 2023

Translational Oncology

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“…In our study, we found that WWC1 can bind with miR‐155‐5p and is inhibited by miR‐155‐5p in HK‐2 and TCMK‐1 cells. The binding of WWC1 and miR‐155‐5p was also observed in cardiac fibroblasts 27 and hepatocellular carcinoma cells 28 . WWC1 overexpression inhibited the progression of sepsis‐induced AKI.…”

Section: Discussionmentioning

confidence: 86%

Long non‐codingRNA XISTalleviates sepsis‐induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulatingmiR‐155‐5p/WWC1axis

Wang

Cao

2021

The Kaohsiung J of Med Scie

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Sepsis is characterized by a severe inflammatory response throughout the whole body and can induce acute kidney injury (AKI). This research aimed to investigate the regulatory mechanisms underlying miR‐155‐5p in sepsis‐induced AKI. CLP‐treated mice were used as an in vivo model of sepsis‐induced AKI, and LPS‐treated HK‐2 and TCMK‐1 cells were used as in vitro models. Bioinformatics analyses and mechanistic assays were utilized to reveal the relationships between molecules. H&E staining was used to reveal morphological changes in kidney tissues. ELISAs were conducted to detect the concentrations of proinflammatory cytokines. We discovered that miR‐155‐5p was prominently upregulated in sepsis‐induced AKI in vivo and in vitro. MiR‐155‐5p inhibition alleviated kidney injury in mice. Moreover, WWC1 served as a direct target of miR‐155‐5p and was negatively regulated by miR‐155‐5p. WWC1 upregulation inhibited the productions of inflammatory cytokines and suppressed apoptosis in vivo and in vitro. In addition, rescue assays demonstrated that WWC1 knockdown counteracted the inhibitory effect of anti‐miR‐155‐5p on inflammation and apoptosis. Moreover, miR‐155‐5p could bind to XIST. XIST expression was downregulated in LPS‐stimulated HK‐2 and TCMK‐1 cells. XIST could negatively regulate miR‐155‐5p expression and positively regulate WWC1 expression. Rescue assays revealed that miR‐155‐5p overexpression significantly reversed the suppressive effects of XIST upregulation on inflammation and apoptosis. In conclusion, our study revealed that the XIST/miR‐155‐5p/WWC1 axis modulated sepsis‐induced AKI progression, providing promising insight into therapeutic targets for sepsis‐induced AKI.

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“…This model of interplay consists of two steps: miR-155 upregulation and the indirect activation of PD-L1 by long non-coding ribonucleic acid X overexpression. miR-155 can also interact with miR-194 and have a synergistic effect on PD-L1 expression [28]. Peng et al proved that miR-155 host gene (miR-155HG) expression is associated with IC expression and has a significant prognostic value in multiple cancers [29].…”

Section: Discussionmentioning

confidence: 99%

PD-L1/miR-155 Interplay in Pediatric High-Grade Glioma

et al. 2022

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High-grade pediatric glioma (p-HGG—WHO 2021, formerly GBM—WHO 2016), as a common, aggressive, and highly lethal primary brain malignancy in adults, accounts for only 3–15% of primary brain tumors in pediatric patients. After leukemia, brain malignancies are the second most common in the pediatric population and first in incidences concerning solid tumors. This study was designed on the basis of 14 pediatric patients hospitalized at Children’s Memorial Health Institute in Warsaw, Poland, due to p-HGG treatment. All the patients had a histopathological diagnosis performed by an experienced neuropathologist according to WHO guidelines (WHO 2016 Grade IV Glioblastoma). A significant correlation was found between the miR-155 concentration and the level of PD-L1 expression in p-HGG tumor tissue. Very few reports have indicated PD-L1 expression in pediatric patients.

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Pivotal role of long non-coding ribonucleic acid-X-inactive specific transcript in regulating immune checkpoint programmed death ligand 1 through a shared pathway between miR-194-5p and miR-155-5p in hepatocellular carcinoma

Cited by 13 publications

References 54 publications

MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer

MALAT-1: Immunomodulatory lncRNA hampering the innate and the adaptive immune arms in triple negative breast cancer

Long non‐codingRNA XISTalleviates sepsis‐induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulatingmiR‐155‐5p/WWC1axis

PD-L1/miR-155 Interplay in Pediatric High-Grade Glioma

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