Pityriasis-Rosea-Like Dermatitis Following Gold Therapy

Wile, Udo J.

doi:10.1001/archderm.1940.01490180114009

Cited by 21 publications

(4 citation statements)

References 16 publications

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“…Barbiturates, 50 methopromazine, 4 captopril, 51-53 clonidine, 51 gold, [54][55][56][57][58][59] metronidazole, 60 D-penicillamine, 61 isotretinoin, 62 levamisole, 61 Pyribenzamine, 63 nonsteroidal anti-inflammatory agents, 64 omeprazole, 65 terbinafine, 66 ergotamine tartrate, 67 and more recently tyrosine kinase inhibitor 68,69 may cause rashes that roughly recall genuine PR (Fig 11). In them, however, the morphologic atypicality is accompanied by histopathologic features that are different from those of typical PR, with interface dermatitis and eosinophils.…”

Section: Drug-induced Pr-like Rashesmentioning

confidence: 99%

Pityriasis rosea: An update with a critical appraisal of its possible herpesviral etiology

Drago

Broccolo

Rebora

2009

Journal of the American Academy of Dermatology

169

163

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Section: Drug-induced Pr-like Rashesmentioning

confidence: 99%

Pityriasis rosea: An update with a critical appraisal of its possible herpesviral etiology

Drago

Broccolo

Rebora

2009

Journal of the American Academy of Dermatology

169

163

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“…Application of Krysolgan in treating Lupus Erythematosus quickly emerged . Increasing toxicity, lack of potency, and lack of a defined mode of action, led to the discontinuation of Krysolgan as first-line therapy …”

Section: Therapeutic Gold Complexesmentioning

confidence: 99%

“…279 Increasing toxicity, lack of potency, and lack of a defined mode of action, led to the discontinuation of Krysolgan as first-line therapy. 280 Aurothioglucose can be viewed as a sugar derived Au(I) polymeric salt, which is often administered by intramuscular injection or intragluteally and marketed as Solganol. The American Medical Association designated Solganol for the treatment of rheumatoid arthritis, particularly for patients that have been unresponsive to conventional therapy.…”

Section: Approved Gold Drugsmentioning

confidence: 99%

Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

et al. 2023

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The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of inflammatory arthritis including rheumatoid and juvenile arthritis; however, new gold agents have been slow to enter the clinic. Repurposing of auranofin in different disease indications such as cancer, parasitic, and microbial infections in the clinic has provided impetus for the development of new gold complexes for biomedical applications based on unique mechanistic insights differentiated from auranofin. Various chemical methods for the preparation of physiologically stable gold complexes and associated mechanisms have been explored in biomedicine such as therapeutics or chemical probes. In this Review, we discuss the chemistry of next generation gold drugs, which encompasses oxidation states, geometry, ligands, coordination, and organometallic compounds for infectious diseases, cancer, inflammation, and as tools for chemical biology via gold–protein interactions. We will focus on the development of gold agents in biomedicine within the past decade. The Review provides readers with an accessible overview of the utility, development, and mechanism of action of gold-based small molecules to establish context and basis for the thriving resurgence of gold in medicine.

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“…Gold.-It has been recognized for some time that gold may cause a lichenoid eruption (Wile and Courville, 1940;Meara, 1953). Gold salts were first used in the treatment of rheumatoid arthritis in 1932.…”

Section: Drugs Causing Lichenoid Eruptionsmentioning

confidence: 99%