Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy

Jang, Min Soo; Kang, Dong Young; Park, Jong Bin; Kim, Joon Hee; Park, Kwi Ae; Rim, Hark; Suh, Kee Suck

doi:10.5021/ad.2016.28.5.540

Cited by 21 publications

(26 citation statements)

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“…The folliculotropic form of MF differs clinically and histopathologically from classic MF. Therefore, it is important to better understand the characteristics of this variant form 3 . Folliculotropic mycosis fungoides (FMF) is a common subtype of MF 4 , which is characterized by various types of skin eruptions, including infiltrative plaques, acneiform lesions, cysts, and alopecic patches.…”

Section: Introductionmentioning

confidence: 99%

Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy

Jang

Park

et al. 2018

Ann Dermatol

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BackgroundFolliculotropic mycosis fungoides (FMF) is a variant of mycosis fungoides (MF) that is characterized clinically by variable types of skin eruptions, including plaques, acneiform lesions, and alopecic patches. Histopathologically, FMF is characterized by folliculotropic infiltrates.ObjectiveThis study was conducted to scrutinize the clinical and histopathologic features of FMF in Koreans and the responses to phototherapy.MethodsTwenty Koreans diagnosed with MF who had histopathologic evidence of folliculotropism were enrolled.ResultsEighteen patients had head-and-neck-region infiltration, while five had solitary lesion. In all patients, the atypical lymphocytic infiltrate had a perifollicular distribution. Twelve patients were treated with ultraviolet A (UVA)-1. Eleven of these 12 patients with early-stage FMF experienced >80% improvement (8: complete remission; 3: partial remission). Four patients, including 2 who relapsed after UVA-1, were treated with photodynamic therapy (PDT), reaching complete remission after PDT.ConclusionAs FMF has variable clinical presentations, skin biopsy is required to confirm the diagnosis. And both UVA-1 and methyl aminolevulinate-PDT are clinically effective in treatment of early-stage FMF.

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Section: Introductionmentioning

confidence: 99%

Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy

Jang

Park

et al. 2018

Ann Dermatol

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“…In addition to the classical type of MF, there are many clinicopathological variants such as hypopigmented, hyperpigmented, hyperkeratotic/verrucous, vegatative/papillomatous, bullous, pustular, porokeratotic, poikilodermic, folliculotropic/ follicular, syringotrophic, granulomatous, ichthyosiform, erythrodermic, palmoplantar, unilesional and pityriasis lichenoides like. They differ clinically and histopathologically from classical type of MF 1,[3][4][5] . These variants and subtypes can also be referred to as atypical forms.…”

Section: Introductionmentioning

confidence: 80%

The evaluation of variants, subtypes and atypical forms of mycosis fungoides in a tertiary hospital

Erdoğan¹,

Ağaoğlu²,

Acer³

et al. 2019

TURKDERM

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Amaç: Mikozis fungoides (MF) en sık görülen kutanöz T hücreli lenfoma tipidir. MF'nin erken lezyonları, alt tipleri ve klinik varyantları, diğer dermatozları taklit edebilir. Çalışmamızda, hastanemiz dermatoloji kliniğinde takipli MF hastalarında klasik veya atipik seyir gösteren varyantların klinik ve histopatolojik özelliklerini ortaya koymayı amaçladık. Gereç ve Yöntem: Hastanemiz dermatoloji kliniğinde 2008-2018 yılları arasında takip edilen MF hastaları retrospektif olarak incelendi. Hastaların sosyodemografik özellikleri, hastalık süresi, klinik bulguları, evreleri, verilen tedaviler ve atipik varyantları kaydedildi. Bulgular: Klinik ve histopatolojik olarak MF tanılı 117 hasta çalışmaya dahil edildi. Hastaların 64'ü kadın (%54), 53'ü erkek (%46) idi. Olguların yaş ortalaması 55,6 idi. Hastalığın başlangıcından tanıya kadar geçen süre ortalama 5, 6 yıldı. Altmış bir hasta (%52,1) evre IA, 20 hasta (%17) evre IB, 31 hasta (26,4) evre IIA, 3 hasta (%2,5) evre IIB, 1 hasta (%0,85) evre IIIB ve 1 hasta (%0,85) evre IVA idi. Altı olguda (%5,1) hastalığın atipik formları saptandı. Üç hasta (%2,5) foliküler MF, birer hasta ise hipopigmente, iktiyoziform ve granülomatöz MF idi. Tedavide topikal steroidlerin yanında 99 hastaya (%84,6) fototerapi, 20'sine (%17) asitretin, 4'üne (%3,4) metotreksat ve 1 hastaya (%0,85) sistemik interferon başlandı. Sonuç: MF varyantları, subtipleri, atipik formları ve MF'nin erken lezyonları, diğer dermatozları taklit ederek tanı ve tedavide gecikmeye neden olabilir. MF varyantlarının, alt tiplerinin ve atipik formlarının erken teşhisi ve tedavisi için MF'den şüphelenilmesi gereklidir. Anahtar Kelimeler: Mikozis fungoides, atipik, varyant Background and Design: Clinical variants, subtypes, and early mycosis fungoides (MF) lesions may mimic other dermatoses. MF is the most common type of cutaneous T-cell lymphomas. In our study, we aimed to evaluate the clinical and histopathological features of patients with classical and variants, subtypes, or atypical forms of MF in our dermatology department. Materials and Methods:We retrospectively evaluated MF patients who were followed up in our dermatology department between 2008 and 2018. Demographic features (age and gender), duration of disease, clinical findings, stages, and treatments of patients with classical and atypical variants of MF were evaluated. Results: A total of 117 patients diagnosed clinically and histopathologically with MF were included in the study. Sixty-four of the patients were female (54%), and 53 were male (46%). The mean age at diagnosis was 55.6±16.03 years. The mean disease duration was 5.6 years. Sixtyone patients (52.1%) had stage IA, 20 patients (17%) had stage IB, 31 patients (26.4%) had stage IIA, three patients (2.5%) had IIB stage, one patient (0.85%) had IIIB stage and one patient (0.85%) had stage IVA disease. Atypical forms of the disease were detected in six patients (5.1%). Three (2.5%) of these cases were follicular MF, and one patient for each type of hypopigmented, ichthyosiform, and granulomatous MF....

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“…The reported cases of CD8 + MF with poikilodermatous clinical presentation had prolonged disease duration, and their response to skin directed therapies was favorable . There are also reports of CD8 + MF cases with atypical clinical presentations masquerading pyoderma gangrenosum, alopecia areata, and pityriasis lichenoides . In the largest cohort of patients, evaluating 67 patients with CD8 + MF conducted by Martinez‐Escala et al ., erythematous scaly lesions were the most common clinical manifestation, and the lower extremities were the most common site of involvement.…”

Section: Discussionmentioning

confidence: 99%

CD8⁺ cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow‐up results of 29 patients

et al. 2019

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Background and objective Less than 5% of cases of mycosis fungoides (MF) present with a cytotoxic/suppressor CD8 + phenotype. This study aimed to evaluate the clinical characteristics, treatment modalities, and clinical course in CD8 + MF patients.Methods In a retrospective analysis of 353 MF patients in a referral center at Ankara University, Turkey, 29 patients that were diagnosed with CD8 + MF were included in the study.Results CD8 + MF cases constituted 8.2% of all MF patients. The age at the time of diagnosis ranged between 6 and 81 years with a median value of 46 years. The female-tomale ratio was 1.41. Patients presented with erythematous scaly (69%), hyperpigmented (58.6%), poikilodermic (17.2%), and hypopigmented (17.2 %) patches/plaques. The most common sites of involvement were the trunk and lower extremities. The most common comorbidity was hypertension (24.1%, n: 7) with 13 patients (44.8%) having a history of at least one autoimmune disease. At the time of diagnosis, 93.2% of the patients had earlystage disease, and 6.8% of the patients had advanced stage. The mean follow-up period was 6.68 AE 6.04 years (range 1-28 years). Most of the patients were treated with skindirected therapies. Complete remission was achieved in 17 (58.6%) patients, eight (27.6%) patients had partial remission, and four (13.8%) patients had stable disease.Conclusions We concluded that CD8 + MF is associated with an indolent course and in most patients, skin-directed therapies were found to be efficient to control the disease.

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Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy

Cited by 21 publications

References 20 publications

Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy

Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy

The evaluation of variants, subtypes and atypical forms of mycosis fungoides in a tertiary hospital

CD8⁺ cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow‐up results of 29 patients

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Pityriasis Lichenoides-like Mycosis Fungoides: Clinical and Histologic Features and Response to Phototherapy

Cited by 21 publications

References 20 publications

Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy

Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy

The evaluation of variants, subtypes and atypical forms of mycosis fungoides in a tertiary hospital

CD8+ cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow‐up results of 29 patients

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CD8⁺ cytotoxic mycosis fungoides: a retrospective analysis of clinical features and follow‐up results of 29 patients