Pityriasis Lichenoides et Varioliformis Acuta as a Complication of COVID-19 Infection

Garza, Henriette De La; Saliba, Elie; Santillan, Monica Rosales; Brem, Candice; Vashi, Neelam A.

doi:10.3390/dermatopathology9030028

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Dermatopathology

2022

DOI: 10.3390/dermatopathology9030028

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Pityriasis Lichenoides et Varioliformis Acuta as a Complication of COVID-19 Infection

Henriette De La Garza

Elie Saliba

Monica Rosales Santillan

et al.

Abstract: Pityriasis lichenoides is an acute and/or chronic skin disease associated with recurrent erythematous papules that self-resolve. While its etiology is unknown, preceding viral infection may play a role. We present an atypical case of a 40-year-old woman with pityriasis lichenoides et varioliformis acuta as a complication of a COVID-19 infection.

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Pityriasis Lichenoides Following SARS-CoV-2 Infection/Vaccination

et al. 2023

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Purpose of Review Pityriasis lichenoides (PL) is a spectrum of dermatological conditions involving polymorphous lesions. Natural history of the condition ranges from acute to chronic. Cases of PL following SARS-CoV-2 infection/vaccination have been reported, but not yet comprehensively reviewed. Hence, the objective of this article is to review and summarize cases of PL following SARS-CoV-2 infection/vaccination in order to guide clinicians in its diagnosis and management. Recent Findings PubMed, Embase, and Web of Science were searched for relevant articles. Thirteen articles, consisting of 14 cases of PL following SARS-CoV-2 infection/vaccination, were identified. Males represented 64.3% of cases, and the average age of those affected was 41.4 years. The majority of cases ( N = 9, 64.3%) were following SARS-CoV-2 vaccination, the most commonly implicated being Pfizer-BioNTech ( n = 8/10, 80%), while four (28.6) followed infection. The overall latency period ranged from 5 days to 1 month. Treatments varied greatly. However, at the time of follow-up, 12/14 patients (85.7%) had either marked improvement or complete resolution of lesions. Summary This review cannot determine causality. However, a temporal association was observed with the case reports, and one case of PL followed SARS-CoV-2 infection and recurred with subsequent vaccination, suggesting an association. Nevertheless, risk of developing PL following SARS-CoV-2 infection/vaccination is likely extremely low. There is also the possibility these cases are purely coincidental. Still, clinicians should be aware of this possible etiology when diagnosing a new or exacerbated case of PL. Finally, given that the majority of patients had marked improvement or complete resolution of lesions at the time of follow-up, clinicians should provide reassurance to their affected patients.

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Pityriasis Lichenoides Following SARS-CoV-2 Infection/Vaccination

et al. 2023

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The role of eosinophils in the differential diagnosis of inflammatory skin diseases

Caro-Chang¹,

Fung²

2023

Human Pathology

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Pityriasis Lichenoides et Varioliformis Acuta as a Complication of COVID-19 Infection

Cited by 2 publications

References 24 publications

Pityriasis Lichenoides Following SARS-CoV-2 Infection/Vaccination

Pityriasis Lichenoides Following SARS-CoV-2 Infection/Vaccination

The role of eosinophils in the differential diagnosis of inflammatory skin diseases

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