Pityriasis lichenoides chronica: stratification by molecular and phenotypic profile

Magro, Cynthia M.; Crowson, A. Neil; Morrison, Carl; Li, Jingwei

doi:10.1016/j.humpath.2006.09.013

Cited by 48 publications

(64 citation statements)

References 34 publications

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“…62,63 The histologic changes of PLEVA include those of interface dermatitis, with basal vacuolar degeneration and a sparse to moderately dense lymphocyte-predominant, superficial, and, typically, deep perivascular inflammatory infiltrate. [56][57][58]64 Scattered necrotic keratinocytes within the epidermis, not seen typically weeks to months and may recur. [56][57][58] Rare cases of PL will progress to lymphoma, and MF is the most common lymphoproliferative disorder to occur in association with PLEVA/PLC.…”

Section: Pityriasis Lichenoidesmentioning

confidence: 99%

“…[56][57][58]64 Scattered necrotic keratinocytes within the epidermis, not seen typically weeks to months and may recur. [56][57][58] Rare cases of PL will progress to lymphoma, and MF is the most common lymphoproliferative disorder to occur in association with PLEVA/PLC. 59 The cause of PL is unknown.…”

Section: Pityriasis Lichenoidesmentioning

confidence: 99%

“…Of note, a majority of CD8+ T-suppressor/cytotoxic cells are seen in cases of PLEVA, whereas CD4+ T-helper cells predominate in cases of PLC, particularly in those cases with progression to MF. 57 in direct association with atypical lymphocytes, are considered by some to be a feature that distinguishes inflammatory "reactive" dermatoses from lymphoproliferative disorders. 57 Both PLEVA and PLC may show scattered, enlarged atypical lymphocytes within the inflammatory infiltrate.…”

Section: Pityriasis Lichenoidesmentioning

confidence: 99%

“…57 in direct association with atypical lymphocytes, are considered by some to be a feature that distinguishes inflammatory "reactive" dermatoses from lymphoproliferative disorders. 57 Both PLEVA and PLC may show scattered, enlarged atypical lymphocytes within the inflammatory infiltrate. Although cases of PLC typically exhibit less overall inflammation than PLEVA, a greater degree of lymphocyte atypia, as well as epidermotropism and Pautrier-like pseudo-abscesses, may be observed-all changes that mimic the findings of MF.…”

Section: Pityriasis Lichenoidesmentioning

confidence: 99%

“…Immunohistochemical staining of skin revealed a T-cell-predominant infiltrate with numerous In addition, loss of CD7 by the large majority of T cells-a fairly characteristic feature of MF-may be observed in cases of PL. 57 Scattered, enlarged CD30+ lymphoid cells may be seen as well and may further raise suspicion for CD30+ lymphoproliferative disorder. 60 One submitted workshop case showed a superficial and deep dermal lymphohistiocytic infiltrate, including some enlarged CD30+ lymphocytes within areas of crusting, ulceration, and marked reactive epidermal changes.…”

Section: Kikuchi-fujimoto Diseasementioning

confidence: 99%

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Mimics of Cutaneous Lymphoma

Sarantopoulos

Palla

Said

et al. 2013

American Journal of Clinical Pathology

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The Society for Hematopathology and European Association for Haematopathology workshop, from October 27 to 29, 2011, in Los Angeles, CA, exhibited many exemplary skin biopsy specimens with interesting inflammatory changes mimicking features of cutaneous lymphoma. This article reviews features observed in cutaneous lymphoid hyperplasia, cutaneous drug reactions, lupus-associated panniculitis, pityriasis lichenoides, hypereosinophilic syndrome, histiocytic necrotizing lymphadenitis, traumatic ulcerative granuloma with stromal eosinophils, and pigmented purpuric dermatosis, as well as a brief review of the pertinent literature and discussion of submitted conference cases. For the pathologist, it is important to be aware of diagnostic pitfalls as well as the limitations of ancillary testing (eg, clonality studies). Finally, correlation with total clinical information, good communication with clinical colleagues, close clinical follow-up with rebiopsy, and prudent use of laboratory studies are vital and will likely offer the best path toward a correct diagnosis.

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