Pituitary Tumors in the Elderly

Kurosaki, Masamichi; Saeger, Wolfgang; Lüdecke, Dieter K.

doi:10.1078/0344-0338-00117

Cited by 31 publications

(23 citation statements)

References 18 publications

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“…We observed CSF leaks in 5 cases (9%); in the general literature this rate varies from 1.2% to 6%, 18 and in elderly population studies it is approximately 4.9%-15.6%. 11,18,28 In 2 of those cases surgical management was required. Postoperative syndrome of inappropriate antidiuretic hormone (SIADH) was observed in 2 cases (3.6%).…”

Section: Discussionmentioning

confidence: 98%

“…11 In the 1980s and 1990s, PAs in elderly patients represented 3%-6.6% of all such lesions, 20,25,28,29,35 and in the 1990s and 2000s, 6%-7.2% of patients with PAs were elderly. 13,21,38 Autopsy series 28 and more recent studies 18 estimate a prevalence of approximately 11%-14%. Of all PAs treated at our department, those in patients ≥ 70 years represent 11.6%.…”

Section: Discussionmentioning

confidence: 99%

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Endoscopic endonasal transsphenoidal surgery in elderly patients with pituitary adenomas

Gondim¹,

Almeida

Albuquerque

et al. 2015

JNS

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Endoscopic transsphenoidal surgery for elderly patients with PAs may be associated with higher complication rates, especially secondary to early transitory complications, when compared with surgery performed in younger patients. Although the worst preoperative clinical status might be observed in this group, age alone is not associated with a worst final prognosis after endoscopic removal of nonfunctioning PAs.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Endoscopic endonasal transsphenoidal surgery in elderly patients with pituitary adenomas

Gondim¹,

Almeida

Albuquerque

et al. 2015

JNS

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“…The tumors were distributed equally throughout the age groups (range: 16-86 years old) and between the genders. In the studies in which PRL immunohistochemistry was performed, 22% to 66% stained positively for PRL [18,20,21,26,[29][30][31][33][34][35][36]38,39]. Buurman and Saeger [39] provide a detailed breakdown of the 334 pituitary adenomas found in 316 pituitaries of the 3048 autopsy cases they examined, finding 39.5% staining for PRL, 13.8% staining for ACTH, 7.2% staining for gonadotropins or a-subunits, 1.8% staining for GH, 0.6% staining for TSH, and 3.0% staining for multiple hormones.…”

Section: Autopsy Findingsmentioning

confidence: 99%

Nonfunctioning Pituitary Tumors and Pituitary Incidentalomas

Molitch

2008

Endocrinology and Metabolism Clinics of North America

162

133

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“…Whereas, ACTH hyperfunction is observed in 65%, 35% are clinically inactive (67). The clinical course is variable, with some tumors demonstrating an aggressive behavior, and others only being found as small incidental inactive adenomas in postmortem pituitaries (68). In a recent study, invasiveness was found in 72% of these adenomas (67).…”

Section: Clinically Inactive (Silent) Acth Cell Adenomasmentioning

confidence: 99%

Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

Saeger

Lüdecke²,

Buchfelder³

et al. 2007

eur j endocrinol

Self Cite

523

346

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In 1996, the German Registry of Pituitary Tumors was founded by the Pituitary Section of the German Society of Endocrinology as a reference center for collection and consultant pathohistological studies of pituitary tumors. The experiences of the first 10 years of this registry based on 4122 cases will herein be reported. The data supplement former collections of the years 1970-1995 with 3480 surgically removed tumors or lesions of the pituitary region. The cases were studied using histology, immunostainings and in some cases also molecular pathology or electron microscopy. The adenomas were classified according to the current World Health Organization classification in the version of 2004. From 1996 on 3489 adenomas (84.6%), 5 pituitary carcinomas (0.12%), 133 craniopharyngiomas (3.2%), 39 meningiomas (0.94%), 25 metastases (0.6%), 22 chordomas (0.5%), 115 cystic non-neoplastic lesions (2.8%), and 46 inflammatory lesions (1.1%, 248 other lesions or normal tissue (6.0%)) were collected by us. The adenomas (100%) were classified into densely granulated GH cell adenomas (9.2%), sparsely granulated GH cell adenomas (6.3%), sparsely granulated prolactin (PRL) cell adenomas (8.9%), densely granulated PRL cell adenomas (0.3%), mixed GH/PRL cell adenomas (5.2%), mammosomatotropic adenomas (1.1%), acidophilic stem cell adenomas (0.2%), densely granulated ACTH cell adenomas (7.2%), sparsely granulated ACTH cell adenomas (7.9%), Crooke cell adenomas (0.03%), TSH cell adenomas (1.5%), FSH/LH cell adenomas (24.8%), null cell adenomas (19.3%), null cell adenoma, oncocytic variant (5.8%), and plurihormonal adenomas (1.3%).

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Pituitary Tumors in the Elderly

Cited by 31 publications

References 18 publications

Endoscopic endonasal transsphenoidal surgery in elderly patients with pituitary adenomas

Endoscopic endonasal transsphenoidal surgery in elderly patients with pituitary adenomas

Nonfunctioning Pituitary Tumors and Pituitary Incidentalomas

Pathohistological classification of pituitary tumors: 10 years of experience with the German Pituitary Tumor Registry

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