Pituitary tumors: Cell type-specific roles for BMP-4

Labeur, Marta; Páez-Pereda, Marcelo; Haedo, Mariana; Arzt, Eduardo; Stalla, Günter

doi:10.1016/j.mce.2010.04.006

Cited by 33 publications

(19 citation statements)

References 31 publications

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“…The effect of gonadal steroids has been reviewed recently (Handa and Weiser 2014). It is possible that variations in E 2 concentrations during the oestrous cycle, and particularly at PE (when maximum concentrations are reached), have an impact on the HPA axis, stimulating the synthesis and/or secretion of ACTH by means of different molecular pathways (Altemus et al 2001;Hall et al 2001;Labeur et al 2010). Moreover, the drop in E 2 concentrations after PE is accompanied by a drop in ACTH concentrations, suggesting that the stimulatory effect of E 2 on corticotroph cells begins to diminish.…”

Section: Discussionmentioning

confidence: 99%

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

Gallelli¹,

Monachesi²,

Miceli³

et al. 2015

Vet. Med. - Czech

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ABSTRACT:The hypothalamic-pituitary-adrenal axis (HPA) is a complex system regulated by multiple factors. Sexual dimorphism of this axis has been described in different species under physiological conditions and it has been proposed that sexual hormones could have an effect on it. There are only a few reports about sex-linked variations in HPA axis hormones in the dog. Thus, studying the impact of sexual hormones on the HPA axis would broaden the knowledge about its function in this species. Therefore, the objective of this study was to determine whether there are variations in HPA plasma hormones (ACTH, alfa-melanocyte-stimulating hormone [α-MSH] and cortisol) according to the sex and photoperiod (positive or negative photoperiod were considered when the duration of the light hours of the day was more than 12 or less than 12, respectively) under basal conditions (like anoestrus) and throughout the oestrous cycle in the female dog. The population under study consisted of 11 intact female and 14 intact male dogs. Under basal conditions neither ACTH nor α-MSH concentrations showed differences between sexes and different photoperiods. Cortisol showed greater values in the negative photoperiod than in the positive, both in females and males (P = 0.03 and P = 0.015, respectively). Throughout the oestrous cycle, all the studied hormones showed variations (P < 0.0001). The greatest concentrations of ACTH were observed at proestrus, while α-MSH and cortisol showed their greatest concentrations at oestrus. The three hormones decreased in diestrus. ACTH and cortisol concentrations were higher in the negative photoperiod (P = 0.04 and P < 0.0001, respectively), while α-MSH concentrations were higher in the positive photoperiod (P = 0.012). In the group of females oestradiol and progesterone correlated with ACTH (r = 0.75, P < 0.0001; r = 0.34, P < 0.01, respectively), α-MSH (r = 0.49, P < 0.0001; r = 0.52, P < 0.0001, respectively) and cortisol (r = 0.33, P < 0.01; r = 0.5, P < 0.0001, respectively). These results show that in females, HPA axis hormones vary during the oestrous cycle in relation to oestradiol and progesterone fluctuations. The ACTH, α-MSH and cortisol concentrations also showed differences between photoperiods in females, but only cortisol did so in males. These findings suggest that sexual hormones could have an effect on the HPA axis. Further research needs to be done to fully understand this interaction and the mechanisms involved.

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Section: Discussionmentioning

confidence: 99%

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

Gallelli¹,

Monachesi²,

Miceli³

et al. 2015

Vet. Med. - Czech

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Section: Sporadinës Haunclassified

“…Jis pri si jun gia prie 1 ar 2 tipo se ri no / tre o ni no ki na zës re cep to riø, ku riø yra ir hi po fizë je [23,31]. Bu vo nu sta ty ta, kad, ser gant HA, su ma þë ja ðio bal ty mo re gu lia ci ja (ti riant jo mRNR), ta èiau me chaniz mas bu vo ne DNR me ti li ni mas, o his to nø mo di fi ka cijos -pa ste bë ti pa di dë jae his to no H3 li zi no 27 tri me ti li ni mo (H3K27Me3) ly giai [31]. Pa ban dþius ið ma tuo ti BMP-4 kon cen tra ci jas ávai riais me to dais (ELI SA, Wes t ern Blot) ir ser gant spo ra di në mis HA, gau ti ávai rûs re zul ta tai, ku riais re mian tis ga li ma bu vo da ry ti ið va dà, kad ðis bal ty mas gal ir ska ti na pro lak ti no mø, bet slo pi na so ma tot ro pi no mø au gimà [23].…”

Section: Sporadinës Haunclassified

Pituitary adenoma: a literature review

Sidaraitė

Glebauskiene

Liutkevičienė

2018

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ÁVADASHi po fi zës ade no mø (HA) pa pli ti mas po pu lia ci jo je yra 1:1000, taip pat jos su da ro 15-20 % vi sø in trak ra ni ji niø na vi kø [1][2][3]. Diag no zë nu sta to ma ávai raus am þiaus as menims (16-79 m.), vi du ti nið kai 37 m. pa cien tams [4]. Pa gal dy dá HA yra skirs to mos á mik ro ade no mas (ma þiau nei 1 cm dia met ro), mak ro a de no mas (1 cm ir di des nio dia metro) ir la bai di de les ade no mas (dau giau nei 4 cm dy dþio) [5]. Daþ niau sios yra mik ro ade no mos, su da ran èios 50-60 % at ve jø [6]. Nors HA yra lai ko mos ge ry bi niais aug liais, vis dau giau moks li nin kø ma no, kad to kia sam prata tu ri kis ti: 30-45 % jø yra lin ku sios plis ti á aky tuo sius ar pleið ta kau lio an èius, yra at spa rios gy dy mui ir lin ku sios atsi nau jin ti [5]. Be vie ti nio spau di mo su kel tø reið ki niø, HA ga li su kel ti ir en dok ri no lo gi nius su tri ki mus, tai gi kli ni ka tam pa la bai ávai ri ir sun ki na sa va lai kae diag nos ti kà, ku ri yra ypaè svar bi ag re sy viø HA at ve ju. Ak ty viai ieð ko ma spe cifi niø bio mar ke riø, ta èiau në vie nas në ra uþ tek ti nai spe cifið kas ðiam na vi kui. Tam áta kos ga li tu rë ti dar ne vi sið kai ið si aið kin ta HA pa to ge ne zë [7,8]. KLASIFIKACIJAPa gal Pa sau lio Svei ka tos Or ga ni za ci jà (PSO), hi po fi zës na vi kai yra skirs to mi á ti pi nes ade no mas, ne ti pi nes ade nomas ir kar ci no mas. Ti pi nës ade no mos, dar ben drai va di namos hi po fi zës ade no mo mis, yra daþ niau sios ið ðios gru pës, jos au ga lë tai, daþ nai tu ri aið kias ri bas ir yra ma þo in va zyvu mo, prie ðin gai nei ati pi nës ade no mos. Hi po fi zës kar cino mos yra re tos, jos ga li at si ras ti de novo ar ba bû ti pas ku tine ade no mø pro gre sa vi mo sta di ja, taip pat jos lin ku sios me ta sta zuo ti tiek cen tri në je ner vø sis te mo je (CNS), tiek ir ki tuo se or ga nuo se [8].HA is to rið kai bu vo kla si fi kuo ja mos pa gal da þy mà si eozi no-he ma tok si li no da þais á aci do fi li nes, ba zo fi li nes ir chro mo fo bi nes ade no mas [8,9]. Da bar yra re mia ma si làs -te lës ti pu, ið ku rios ki lo aug lys, ir ade no mos hor mo ni niu ak ty vu mu. Jei tam tik rø hor mo nø kon cen tra ci jos pa di dë ji -14 NEUROLOGIJOS SEMINARAI • ISSN 1392-3064 / eISSN 2424-5917 © Neurologijos seminarai, 2018. Open Ac cess. This ar ti cle is dis trib uted un der the terms of the Cre ative Com mons At tri bu tion 4.0 Inter na tional Li cense CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/), which per mits un re stricted use, dis tri bu tion, and re produc tion in any me dium, pro vided you give ap pro pri ate credit to the orig i nal au thor(s) and the source, pro vide a link to the Cre ative Com mons li cense, and in di cate if changes were made. San trau ka. Hi po fi zës ade no ma (HA) yra vie nas daþ niau siø in trak ra ni ji niø na vi kø, ga lin tis su kel ti neu ro lo gi nius ir (ar) en dok ri no lo gi nius simp to mus. Vis gi, pa to ge ne zë dar në ra iki galo aið ki, ðei mi niai at ve jai ir su jais su si jae sin dro mai yra ...

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“…In gonadotropes, GnRH induces an antiproliferative response that is further modified by activin, suggesting that transforming growth factor (TGF)-β signaling cooperates with GnRH to provide the appropriate differentiated phenotype (Zhang et al, 2006). There is also increasing evidence that locally produced BMPs play a critical role in the pathogenesis of human pituitary tumors (Labeur et al, 2010). In this regard, we previously reported the characteristics of human FSH-producing adenomas compared with those of nonfunctioning adenomas and showed that the expression of follistatin, which neutralizes BMP/activin actions by binding, was decreased in human FSH-producing adenomas (Takeda et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells

Takeda

Otsuka

Takahashi

et al. 2012

Molecular and Cellular Endocrinology

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It is known that bone morphogenetic proteins (BMPs) regulate gonadotropin transcription and production by pituitary gonadotrope cells. However, the role of BMPs in gonadotropin-releasing hormone (GnRH)-induced FSH production remains uncertain. Here, we describe a functional link between BMP-6 and BMP-7 signals and FSH transcriptional activity induced by GnRH using mouse gonadotrope LβT2 cells. In LβT2 cells, BMP-6 and BMP-7 increased mouse FSHβ-promoter activity in a concentration-dependent manner. The induction by BMP-6 and BMP-7 was inhibited by treatment with extracellular domains of ActRII but not BMPRII. These findings suggest that the type II receptor ActRII participates in BMP-induced FSHβ transcription regulation. Notably, BMP-6, but not BMP-7, enhanced GnRH-induced FSHβ-promoter activity in LβT2 cells. Since GnRH stimulated MAPK phosphorylation in LβT2 cells, a functional link between MAPK and FSHβ transcription was examined. Inhibition of the ERK pathway, but not that of p38 or SAPK/JNK signaling, suppressed GnRH-induced FSHβ transcription, suggesting that ERK is functionally involved in GnRH-induced FSHβ transcription. Co-treatment with BMP-7, but not with BMP-6, suppressed GnRH-induced MAPK phosphorylation in LβT2 cells. Thus, the difference between BMP-6 and BMP-7 in enhancing GnRH-induced FSHβ transcription may be due to the differential effects of BMP ligands on GnRH-induced ERK signaling. On the other hand, GnRH reduced Smad1/5/8 phosphorylation but increased Smad6/7 expression. These findings imply the presence of a functional link between GnRH action, MAPK signaling and the BMP system in pituitary gonadotropes for fine-tuning of FSH gene expression.

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Pituitary tumors: Cell type-specific roles for BMP-4

Cited by 33 publications

References 31 publications

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

Plasma ACTH, α-MSH and cortisol variations in the dog during the oestrous cycle in different photoperiods

Pituitary adenoma: a literature review

Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells

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