Pituitary side effects of old and new drugs

Zatelli, Maria Chiara; Ambrosio, Maria Rosaria; Bondanelli, Marta; Uberti, Ettore C. degli

doi:10.1007/s40618-014-0133-2

Cited by 18 publications

(7 citation statements)

References 74 publications

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“…Conversely, patients with hypothyroidism showed a high frequency of both CNS and peripheral abnormalities in electrophysiological studies, even in the asymptomatic ones (28). Interestingly, opioids have been found to modulate TSH release, increasing TSH levels, whereas tricyclic antidepressants, glucocorticoids and dopamine reduce the response of TRH (29). However, further experimental and clinical studies are needed in order to investigate the role of TRH in the physiopathology of migraine.…”

Section: Discussionmentioning

confidence: 99%

Subclinical hypothyroidism is associated with migraine: A case-control study

et al. 2018

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Background Recent studies suggested a potential association between both overt and subclinical hypothyroidism and migraine. Aims of this study were to estimate the comorbidity of migraine in patients with subclinical hypothyroidism and to evaluate associated clinical characteristics. Methods Using a case-control strategy, 151 consecutive subclinical hypothyroidism patients (mean age 48.36 ± 15.86 years) and 150 controls (mean age 50.86 ± 9.19 years) were recruited. In all subjects, migraine characteristics were collected through a direct interview. Clinical and biochemical parameters (thyroid-stimulating hormone, free triiodothyronine, free thyroxine, and anti-thyroid antibodies) were compared between subclinical hypothyroidism patients in comorbidity with migraine and subclinical hypothyroidism patients without migraine. Results The prevalence of lifetime migraine was significantly higher in subclinical hypothyroidism patients in comparison with controls (46% vs. 13%, p < 0.001; OR 5.80; 95% CI = 3.35-10.34). Both migraine without and with aura were significantly higher in subclinical hypothyroidism patients than controls ( p < 0.001 and p = 0.010, respectively). Thyroid hormones and concentrations of antibodies did not differ between subclinical hypothyroidism patients with and without migraine. Interestingly, a comorbidity for autoimmune diseases was observed in subclinical hypothyroidism patients with migraine in respect to those without migraine ( p = 0.005). Conclusions Our data suggest that migraine is more frequent in patients with subclinical hypothyroidism in respect to controls. Further studies are needed in order to confirm this association.

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Section: Discussionmentioning

confidence: 99%

Subclinical hypothyroidism is associated with migraine: A case-control study

et al. 2018

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“…However, much less is understood regarding the development of HPA dysfunction in patients who receive NS and RT for the management of non-pituitary intracranial neoplasms. As many of these individuals may be taking medications known to effect the HPA axis prior to NS (including glucocorticoids, dopamine, thyroxine, antidepressants, benzodiazepines) and/or may present with hormone abnormalities related to acute illness following NS, evaluation of the HPA axis during the perioperative period is often withheld [14,22]. Likewise, as the tumors are distant to the HPA, routine post-NS endocrine assessment/follow-up is often considered unnecessary.…”

Section: Discussionmentioning

confidence: 99%

Time Dependence of Radiation-induced Hypothalamic–Pituitary Axis Dysfunction in Adults Treated for Non-pituitary, Intracranial Neoplasms

et al. 2017

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“…Patients developing hypophysitis may also develop LH and FSH deficiencies as well as adrenocorticotropin hormone, thyroid-stimulating hormone (TSH) and in some cases growth hormone (GH) deficiency (GHD), diabetes insipidus (DI) or syndrome of inappropriate antidiuretic hormone secretion [45][46][47]. The onset of hypophysitis and hence of hypopituitarism should be promptly diagnosed and treated [48]. HH has been described in 83-87% of male patients with hypophysitis treated with anti-CTLA4 antibodies [49].…”

Section: Chemotherapy Immunological Treatment and Their Effects On Tmentioning

confidence: 99%

Late Effects of Parasellar Lesion Treatment: Hypogonadism and Infertility

et al. 2020

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Central hypogonadism, also defined as hypogonadotropic hypogonadism, is a recognized complication of hypothalamic-pituitary-gonadal axis damage following treatment of sellar and parasellar masses. In addition to radiotherapy and surgery, CTLA4-blocking antibodies and alkylating agents such as temozolomide can also lead to hypogonadism, through different mechanisms. Central hypogonadism in boys and girls may lead to pubertal delay or arrest, impairing full development of the genitalia and secondary sexual characteristics. Alternatively, cranial irradiation or ectopic hormone production may instead cause early puberty, affecting hypothalamic control of the gonadostat. Given the reproductive risks, discussion of fertility preservation options and referral to reproductive specialists before treatment is essential. Steroid hormone replacement can interfere with other replacement therapies and may require specific dose adjustments. Adequate gonadotropin stimulation therapy may enable patients to restore gametogenesis and conceive spontaneously. When assisted reproductive technology is needed , protocols must be tailored to account for possible long-term gonadotropin insufficiency prior to stimulation. The aim of this review was to provide an overview of the risk factors for hypogonadism and infertility in patients treated for parasellar lesions and to give a summary of the current recommendations for management and follow-up of these dysfunctions in such patients. We have also briefly summarized evidence on the physiological role of pituitary hormones during pregnancy, focusing on the management of pituitary deficiencies.

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Pituitary side effects of old and new drugs

Cited by 18 publications

References 74 publications

Subclinical hypothyroidism is associated with migraine: A case-control study

Subclinical hypothyroidism is associated with migraine: A case-control study

Time Dependence of Radiation-induced Hypothalamic–Pituitary Axis Dysfunction in Adults Treated for Non-pituitary, Intracranial Neoplasms

Late Effects of Parasellar Lesion Treatment: Hypogonadism and Infertility

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