Pituitary—ovarian relationships in women approaching the menopause

Abe, Toru; Yamaya, Yoshihiro; Wada, Yuichi; Suzuki, Masakuni

doi:10.1016/0378-5122(83)90019-1

Cited by 13 publications

(4 citation statements)

References 4 publications

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“…It is currently believed that uterine peristalsis is controlled by estradiol released by the dominant follicle (11). Since estradiol levels remain unchanged during the reproductive age period but significantly decrease after menopause, our result agrees with these hormonal changes (17). As for peristalsis during a postmenopausal state, only three cases, as evaluated by transvaginal ultrasound (TVUS), have been reported (9).…”

Section: Discussionsupporting

confidence: 90%

Uterine peristalsis and junctional zone: correlation with age and postmenopausal status

et al. 2016

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Background Although age-related change of junctional zone (JZ) of the uterus has been known, there has been no previous systematic study of age-related changes of uterine peristalsis that is observed as the wave conduction of the thickest or darkest area within the JZ. Purpose To examine the age-related changes of uterine peristalsis in pre and postmenopausal women using cine magnetic resonance imaging (MRI), and to determine the correlation between peristalsis and JZ on T2-weighted (T2W) imaging. Material and Methods Cine MRI analysis was performed in 64 premenopausal volunteers and in 43 postmenopausal women. The peristaltic frequency, JZ detectability, and JZ thickness were evaluated and compared between the two groups. In the premenopausal group, the correlations between age and each item was examined. In the postmenopausal group, the number of years after menopause was used instead of age. The correlation between peristaltic frequency and JZ detectability or thickness was also analyzed. Results Peristaltic frequency and JZ detectability significantly differed between the two groups, while JZ thickness did not. Peristaltic frequency did not vary significantly with age before menopause and no peristalsis was observed after menopause. JZ detectability did not change significantly with age or number of years after menopause, while JZ thickness significantly increased with age before menopause, but did not vary after menopause. A significant moderate correlation was observed between JZ detectability and peristaltic frequency, but not between JZ thickness and peristaltic frequency. Conclusion Uterine peristalsis frequency did not change significantly according to age, but observed peristalsis on MRI significantly decreased after menopause.

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Section: Discussionsupporting

confidence: 90%

Uterine peristalsis and junctional zone: correlation with age and postmenopausal status

et al. 2016

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“…In contrast to estradiol, progesterone declines during the transition period. Although lower progesterone has been consistently reported by several authors [45, 50] and is one of the most striking and reproducible features of perimenopause, medical research has remained focused almost entirely on estrogens. In VCD-treated mice, progesterone levels have been evaluated in estropause [14, 23] or in proestrus [15], making difficult the comparison with our results, since our study was carried out in diestrus.…”

Section: Discussionmentioning

confidence: 92%

Endocrine profile of the VCD-induced perimenopausal model rat

et al. 2019

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During the transition to menopause, women experience a variety of physical and psychological symptoms that are directly or indirectly linked to changes in hormone secretion. Establishing animal models with intact ovaries is essential for understanding these interactions and finding new therapeutic targets. In this study, we assessed the endocrine profile, as well as the estrous cycle, in the 4-vinylcyclohexene diepoxide (VCD)-induced follicular depletion rat model in 10-day intervals over 1 month to accurately establish the best period for studies of the transition period. Twenty-eight-day-old female rats were injected daily with VCD or oil s.c. for 15 days and euthanized in the diestrus phase approximately 70, 80, 90 and 100 days after the onset of treatment. The percentage of rats showing irregular cycles and the plasma level of FSH increased only in the 100-day VCD group. Plasma anti-Müllerian hormone (AMH) and progesterone were lower in all VCD groups compared to control groups, while estradiol remained unchanged or higher. As in control groups, dihydrotestosterone (DHT) progressively decreased in the 70-90-day VCD groups; however, it was followed by a sharp increase only in the 100-day VCD group. No changes were found in plasma corticosterone, prolactin, thyroid hormones or luteinizing hormone. Based on the estrous cycle and endocrine profile, we conclude that 1) the time window from 70 to 100 days is suitable to study a perimenopause-like state in this model, and 2) regular cycles with low progesterone and AMH and normal FSH can be used as markers of the early/mid-transition period, whereas irregular cycles associated with higher FSH and DHT can be used as markers of the late transition period to estropause.

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“…Of the 12 studies of perimenopausal endocrinology shown in Table 1, all of those measuring urine excretions but only two of those measuring serum hormones tabulated the percentage of the cycles that were ovulatory. In paid midwifery students studied by Abe et al (90), five of eight cycles were nonovulatory. Two studies excluded otherwise eligible women because they were nonovulatory (89,100 (65).…”

Section: August 1998mentioning

confidence: 99%