Pituitary Necrosis in Diabetes Mellitus

Brennan, Cynthia; Malone, Rubie M.; Weaver, J. A.

doi:10.1016/s0140-6736(56)91387-3

Cited by 58 publications

(11 citation statements)

References 20 publications

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“…Pituitary apoplexy has been associated with numerous pathological states including diabetes mellitus (Brennan et al, 1956), obstetrical haemorrhage (Sheehan & Murdoch, 1936) and increases in intracranial pressure (Dawson & Kothandram, 1972). Several medications have been associated with pituitary apoplexy; these include anticoagulants (Nourizadeh & Pitts, 1965), isosorbide dinitrate (Bevan et al, 1987), chlorpromazine (Silverman et al, 1985) and bromocriptine (Wakai et al, 1981).…”

Section: Discussionmentioning

confidence: 99%

Pituitary apoplexy after leuprolide administration for carcinoma of the prostate

Morsi

Jamal

Silverberg

1996

Clinical Endocrinology

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The syndrome of pituitary apoplexy has been reported to occur after the administration of several different medications. We report a case in which pituitary apoplexy developed shortly after the administration of leuprolide in a patient with prostate cancer. Leuprolide is a potent gonadotrophin releasing hormone (GnRH) analogue used to suppress leuteotrophic hormone (LH) and testosterone levels in patients with metastatic prostate cancer. LH and testosterone levels actually rise in the first week after its administration before becoming suppressed. We suspect that this acute stimulating effect of leuprolide is linked to the acute onset of pituitary apoplexy in a patient with a possible gonadotrophoma.

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Section: Discussionmentioning

confidence: 99%

Pituitary apoplexy after leuprolide administration for carcinoma of the prostate

Morsi

Jamal

Silverberg

1996

Clinical Endocrinology

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“…Antepartum pituitary failure in patients with T1DM, however, has been reported only rarely and in a small number of patients ( Table 2 ). Pituitary infarcts are more common in patients with diabetes as found by Brennan et al, in a post-mortem study, reported in 1956 that the prevalence of small pituitary infarctions in patients with diabetes was 1 / 50, whereas in patients without diabetes it was 1 / 550 ( Brennan et al, 1956 ). These were small infarctions in patients without clinical evidence of hypopituitarism.…”

Section: Discussionmentioning

confidence: 71%

An Unusual Cause of Severe Hypoglycaemia in Type 1 Diabetes Mellitus. Antepartum Pituitary Failure: A Case Report and Literature Review

Tahrani

West²,

Macleod³

2007

Exp Clin Endocrinol Diabetes

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We describe an unusual cause of severe hypoglycaemia, secondary to hypopituitarism as a result of antepartum pituitary failure, in a pregnant patient with type 1 diabetes mellitus (T1DM). Antepartum pituitary failure is a very rare condition, which has been reported only in a very small number of pregnant patients with diabetes and presents with an acute onset headache and a sub-arachnoid haemorrhage-like picture. It is a potentially fatal condition to the mother and the child if not recognised and treated. Our case report highlights the importance of thinking about hypopituitarism, as a cause of recurrent hypoglycaemia in pregnant patients with T1DM as missing the diagnosis could be fatal to the mother and child.

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“…Vascular events have been implicated in patients with diabetes mellitus, 28 hypertension, 4 and anticoagulation. Apoplexy typically results from hemorrhage into a pituitary tumor.…”

Section: Pituitary Apoplexymentioning

confidence: 99%

Pituitary apoplexy associated with anterior communicating artery aneurysm and aberrant blood supply

Shahlaie

Olaya

Hartman

et al. 2006

Journal of Clinical Neuroscience

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Pituitary Necrosis in Diabetes Mellitus

Cited by 58 publications

References 20 publications

Pituitary apoplexy after leuprolide administration for carcinoma of the prostate

Pituitary apoplexy after leuprolide administration for carcinoma of the prostate

An Unusual Cause of Severe Hypoglycaemia in Type 1 Diabetes Mellitus. Antepartum Pituitary Failure: A Case Report and Literature Review

Pituitary apoplexy associated with anterior communicating artery aneurysm and aberrant blood supply

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