“…Alkalinity/acidity of variants, and their half-life in the circulation, depends in part on sialylation and sulfation of terminal galactose. There is a shift to less basic variants of LH at the evening of proestrus and to more basic variants of LH after ovariectomy (De Biasi et al, 2002), while FSH is shifted to less acidic variant at midcycle (Wide and Bakos, 1993), implying endocrine regulation of glycosylation enzymes’ activity (Damian-Matsumura et al, 1999; Ulloa-Aguirre et al, 2001). Furthermore, human FSH is primarily siaylated while LH is sulfated, a difference that contributes to their variable clearance rates (Green et al, 1986).…”