Pituitary growth hormone and Creutzfeldt-Jakob disease.

Macário, M; Vaisman, Mario; Buescu, Alexandru; Neto, Vivaldo Moura; Araújo, Henriqueta; Chagas, Carlos

doi:10.1136/bmj.302.6785.1149

Cited by 16 publications

(3 citation statements)

References 8 publications

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“…This is the first report of gCJD presenting E200K mutation in Brazil, where no epidemiological studies have been performed to investigate the proportion of sporadic, acquired or familial CJD. To date, two cases of acquired CJD associated with human growth hormone therapy have been reported, 14 , 15 while only two genetic forms of CJD associated with mutation at codon 210 and at codon 183 have been described. 16 , 17 The clinical presentation of fCJD associated with E200K is quite similar to sCDJ.…”

Section: Discussionmentioning

confidence: 99%

Creutzfeldt-Jakob disease associated with a missense mutation at codon 200 of the prion protein gene in Brazil

Smid

Martins

Landemberger

et al. 2007

Dement. neuropsychol.

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Genetic Creutzfeldt-Jakob disease (gCJD) represents less than 15% of CJD cases, and its clinical picture may be either indistinguishable from that of sporadic CJD (sCJD) or be atypical, usually with younger onset and longer duration. We report a case of 59-year old Brazilian man who presented rapidly progressive cognitive decline and cerebellar ataxia. EEG revealed periodic activity. A brother and a cousin of the patient had CJD. A point mutation at codon 200 (E200K) of the prion protein gene (PRNP) was found and death occurred 11 months after onset of symptoms. Autopsy was not performed. The clinical presentation of gCJD associated with E200K, which is the most frequent PRNP mutation, is quite similar to sCDJ. This is the first report of E200K mutation in Brazil, and it is possible that a more systematic search for its occurrence may show it to be relatively frequent in Brazil.

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Section: Discussionmentioning

confidence: 99%

Creutzfeldt-Jakob disease associated with a missense mutation at codon 200 of the prion protein gene in Brazil

Smid

Martins

Landemberger

et al. 2007

Dement. neuropsychol.

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“…Scrapie from sheep is also transmissible between species (Prusiner, 1991). The concern over cross-species infection from 'mad cow' disease and the realization that extracts of growth hormone derived from human pituitary used to treat children with growth difficulties have led to over 30 cases of prion disease (Macario et al, 1991) has only served to heighten interest in the basic biology of this unusual infection.…”

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confidence: 99%

Prion disease: The essential facts

Clinton

Roberts

1992

Int J Geriat Psychiatry

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“…There have now been a total of ten cases of Creutzfeldt-Jakob disease iden tified in patients treated with pituitary GH prepared in the United States. Of these, eight occurred in the United States [7][8][9][10], while one patient in Brazil [11] and one in New Zealand [12] were associated with the use of pitu itary GH prepared in the United States. It soon became apparent that this problem was not limited to the GH pre pared from pituitary glands in the United States [ 13.…”

Section: Introductionmentioning

confidence: 99%

Untoward Events in Patients Treated with Growth Hormone in the USA

Hintz

1992

Horm Res

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Since 1960 more than 30,000 children have been treated with growth hormone (GH) in the USA. Ten cases of Creutzfeldt-Jakob disease have been associated with the use of GH purified from pituitaries in the USA, and more cases may appear in the future. Ten cases of leukemia or preleukemia have been reported in patients undergoing GH treatment in the US. Eight of these patients had previously diagnosed tumors of the central nervous system. As the indications for GH treatment broaden, and the dosages of GH increase, more unfavorable clinical events linked directly to the biological actions of GH can be expected to occur. Continued surveillance for clinically important GH-associated events is important.

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Pituitary growth hormone and Creutzfeldt-Jakob disease.

Cited by 16 publications

References 8 publications

Creutzfeldt-Jakob disease associated with a missense mutation at codon 200 of the prion protein gene in Brazil

Creutzfeldt-Jakob disease associated with a missense mutation at codon 200 of the prion protein gene in Brazil

Prion disease: The essential facts

Untoward Events in Patients Treated with Growth Hormone in the USA

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