Pituitary Gonadotropins—Chemistry, Extraction, and Immunoassay

Stevenson, Patricia M.; Loraine, J. A.

doi:10.1016/s0065-2423(08)60144-4

Cited by 3 publications

(1 citation statement)

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“…Increased uterine weight in laboratory rodents has long been used as a bioindicator of the presence of estrogenic steroids [ 46 , 47 ]. Increased edema, hypertrophy, and hyperplasia of the endometrium represented the uterotrophic effects of estrogens [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats

Hsu

Hsueh

et al. 2021

IJMS

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The uterine first-pass effect occurs when drugs are delivered vaginally. However, the effect of vaginally administered recombinant human follicle-stimulating hormone (rhFSH) on ovarian folliculogenesis and endometrial receptivity is not well established. We aimed to compare the efficacy of rhFSH administered vaginally and abdominally in clinical in vitro fertilization (IVF) treatment, pharmacokinetic study, and animal study. In IVF treatment, the number of oocytes retrieved, endometrial thickness and uterine artery blood perfusion were not different between women who received the rhFSH either vaginally or abdominally. For serum pharmacokinetic parameters, significantly lower Tmax, clearance, and higher AUC and T1/2_elimination of rhFSH were observed in women who received rhFSH vaginally, but urine parameters were not different. Immature female rats that received daily abdominal or vaginal injections (1 IU twice daily for 4 days) or intermittent vaginal injections (4 IU every other day for two doses) of rhFSH had more total follicles than the control group. In addition, the serum progesterone and progesterone receptors in the local endometrium were significantly higher in the groups treated with intermittent abdominal or vaginal injection of rhFSH, compared with those who recieved daily injection. In summary, vaginal administration of rhFSH may provide an alternative treatment regimen in women receiving IVF.

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Section: Discussionmentioning

confidence: 99%

Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats

Hsu

Hsueh

et al. 2021

IJMS

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Immobilized Enzymes and Proteins in Urinalysis

Boguslaski¹,

Smith²

1977

Biomedical Applications of Immobilized Enzymes and Proteins

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Thyrotropin–a Lipolytic Hormone?

Stevenson¹,

Fernie²,

Kirkham³

et al. 1973

European Journal of Biochemistry

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It is widely accepted that human thyrotropin causes lipolysis in fat cells isolated from a variety of sources. An investigation into the use of this lipolytic activity as a means of tracing thyrotropin through a fractionation procedure revealed that the biological and lipolytic activities of this hormone are separable and are probably, therefore, caused by two different entities. It is obvious that the measurement of lipolysis is an unsuitable assay for thyrotropin. It was shown that this lipotropic compound is antigenic and likely also to interfere with the accuracy of a radio‐immunoassay for thyrotropin.

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Pituitary Gonadotropins—Chemistry, Extraction, and Immunoassay

Cited by 3 publications

References 125 publications

Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats

Ovarian Folliculogenesis and Uterine Endometrial Receptivity after Intermittent Vaginal Injection of Recombinant Human Follicle-Stimulating Hormone in Infertile Women Receiving In Vitro Fertilization and in Immature Female Rats

Immobilized Enzymes and Proteins in Urinalysis

Thyrotropin–a Lipolytic Hormone?

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