Pituitary gland volumes in children with normal endocrine function

Çolaklar, Anıl; Fítöz, Suat

doi:10.1007/s00247-022-05505-5

Cited by 3 publications

(2 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar study was performed on humans, and the size of the gland varied according to gender and hormonal status. 23,24 In humans, a marked increase in gland volume has been observed in females during early puberty compared with males, 25 followed by a progressive decrease in size after adolescence. 26 All the rats in our study were sexually mature, considering that sexual maturity in rats occurs within the first month of life.…”

Section: Discussionmentioning

confidence: 99%

Sonography of the pituitary gland in pet rats

Pelligra,

Petrini,

Puccinelli

et al. 2023

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Pituitary gland (PG) tumors are common in rats over the age of 2. CT and MRI can be difficult to apply in this species, whereas ultrasound is more feasible and useful. To our knowledge, there are no studies on PG ultrasound in rats. The aim of this prospective, analytical study was to evaluate the reliability of ultrasound in identifying PG, to define the ultrasound dimension of the gland in a group of rats with no evidence of pituitary diseases, and to examine its correlations with age, sex, and weight. After localizing the PG with an MRI study on one rat, the gland was identified in 21 rats by ultrasound by two sonographers using a ventral neck approach and a transversal scan with a linear probe. The gland appears as a hypoechoic oval structure with a thin hyperechoic margin. The rats (15 male and 6 female) ranged from 4 to 18 months in age (median 6 months) and from 270 to 640 g in weight (median 370 g). The median pituitary width was 3.96 mm (interquartile range 25–75%: 6–4.5 mm), and the median height was 1.48 mm (interquartile range 25–75%: 1.3–1.67 mm). There was no statistically significant correlation between PG size and rat weight, gender, or age. We believe that these ultrasound measurements could be useful for the diagnosis of pituitary disease, irrespective of whether neurological symptoms are present. We report a clinical case of a rat with a pituitary mass detected by ultrasound and CT.

show abstract

Section: Discussionmentioning

confidence: 99%

Sonography of the pituitary gland in pet rats

Pelligra,

Petrini,

Puccinelli

et al. 2023

Vet Radiology Ultrasound

View full text Add to dashboard Cite

show abstract

“…In TD children, with average pubertal onset and normal endocrine function, pituitary gland volumes in both sexes increase gradually with age, show a growth spurt during early puberty, and are larger in girls than boys. 38 , 39 , 40 Studies of pituitary volumes in either precocious or delayed puberty are sparse, with some reports suggesting larger pituitary volumes in children with precocious puberty compared with age-matched controls. 41 , 42 Since 7q11.23 CNVs display differential timing of pubertal onset, we hypothesized that pituitary volumes may also vary across these CNVs, though studies examining this potential neural correlate are lacking.…”

Section: Introductionmentioning

confidence: 99%

Altered pubertal timing in 7q11.23 copy number variations and associated genetic mechanisms

Wei,

Gregory,

Nash

et al. 2024

iScience

View full text Add to dashboard Cite

Pitfalls of diagnosing pituitary hypoplasia in the patients with short stature

Kiremitci Yilmaz,

Yilmaz Ovali,

Ozalp Kizilay

et al. 2024

Endocrine

View full text Add to dashboard Cite

Purpose Height age (HA) and bone age (BA) delay is well known in the patients with short stature. Therefore assessing pituitary hypoplasia based on chronological age (CA) might cause overdiagnosis of pituitary hypoplasia. We aimed to investigate the diagnostic and prognostic value of the PH and PV based on CA, HA, or BA in the patients with GHD. Methods Fifty-seven patients with severe and 40 patients with partial GHD and 39 patients with ISS assigned to the study. For defining the most accurate diagnosis of pituitary hypoplasia, PH and PV were evaluated based on CA, BA and HA. The relationship of each method with clinical features was examined. Results The mean PV was significantly larger in patients with ISS compared to the GH-deficient patients. PV was more correlated with clinical features including height SDS, stimulated GH concentration, IGF-1 and IGFBP-3 SDS, height velocity before and after rGH therapy. We found BA-based PV could discriminate GHD from ISS (Sensitivity: 17%, specificity: 98%, positive predictive value: 94%, negative predictive value: 39%), compared to the other methods based on PH or PV respect to CA and HA. 3% of patients with ISS, 17% of patients with GHD had pituitary hypoplasia based on PV-BA. Conclusion PV based on BA, has the most accurate diagnostic value for defining pituitary hypoplasia. But it should be kept in mind that there might be still misdiagnosed patients by this method. PV is also a significant predictor for the rGH response.

show abstract

Pituitary gland volumes in children with normal endocrine function

Cited by 3 publications

References 17 publications

Sonography of the pituitary gland in pet rats

Sonography of the pituitary gland in pet rats

Altered pubertal timing in 7q11.23 copy number variations and associated genetic mechanisms

Pitfalls of diagnosing pituitary hypoplasia in the patients with short stature

Contact Info

Product

Resources

About