Pituitary function in human pseudocyesis

Forsbach, G; Güitrón, Alfredo; Muñoz, María Julia; Bustos, H.H.

doi:10.1007/bf03347148

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…Elevated prolactin levels lead to galactorrhea or lactation, the persistence of corpus luteum, and suppression of Follicle-stimulating hormone and LH secretion, ultimately resulting in amenorrhea ( 13 , 14 , 25 , 29 , 35 , 36 , 38 ). Corpus luteum is an initial source of circulating progesterone during the menstrual cycle, pregnancy, and pseudopregnancy ( 25 , 39 ). Other neuroendocrinologic disturbances (e.g., decrease in LH and an excessive prolactin response to thyrotropin-releasing hormone stimulation, abnormality in growth hormone, Adrenocorticotropic hormone and cortisol levels were seen in pseudocyesis cases ( 15 , 24 ).…”

Section: Resultsmentioning

confidence: 99%

Biopsychosocial view to pseudocyesis: A narrative review

Azizi

Elyasi

2017

IJRM

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Background:Pseudocyesis is a psychopathological clinical syndrome in which a non-pregnant woman firmly believes herself to be pregnant and manifests many symptoms and signs of pregnancy. Although the exact etiology of pseudocyesis has not been determined.Objective:This study was conducted with the aim of assessing the biopsychosocial view to pseudocyesis.Materials and Methods:A comprehensive search in electronic databases such as Google Scholar, PubMed, ScienceDirect, Web of Science, and Scopus was conducted between 1943-2016 to retrieve pseudocyesis related articles. For this purpose, 1149 articles were collected and 66 items were used.Results:Findings were classified into 2 main categories: a) pseudocyesis etiology, which could include (biological psychological factors and psychiatric disorders, and social factors); and b) pseudocyesis management.Conclusion:Pseudocyesis results from a multidimensional group of factors, and a holistic and comprehensive approach should be taken to its treatment. Cooperation between gynecologists and psychiatrists would likely be useful in addressing the condition.

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Section: Resultsmentioning

confidence: 99%

Biopsychosocial view to pseudocyesis: A narrative review

Azizi

Elyasi

2017

IJRM

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“…The underlying mechanism of such a psychosomatic reaction may be an extemporaneous activation of neuroendocrine 'maternal subroutine' characteristics of pregnancy (8). Abnormality in neurotransmitter pathways resulting in alterations of pituitary secretion has also been considered aetiological (9). These reported inconsistencies in the endocrine profile may also be due to the study on a small sample of cases of 'true' pseudocyesis.…”

Section: Discussionmentioning

confidence: 99%

Pseudocyesis and its Modern Perspective

Trivedi

Singh

1998

Aust NZ J Obst Gynaeco

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EDITORIAL COMMENT We accepted this paper for publication because we have not reported previously on pseudocyesis, which is a rare condition, especially if 'jirst trimester cases ' are excluded where there has been confusion with interpretation of intervals of amenorrhoea. These cases can occur at the climacteric when elevated levels of LH can give a false positive HCG test result with older methods of assay and add further to the temporary clinical confusion. The classical clinical picture, unlike the 3 cases reported in this papel; is said to be the nullipara approaching the time of the climacteric who is anxious to conceive. Queen Mary's case must be the most famous on record and also the best documented by means of the serial bulletins issued for her loyal subjects concerning the progress of her royal pregnancy (A). The editor can remember only I case of 'late pregnancy' pseudocyesis in 40 years of obstetric practice. This woman was finally convinced of her nonpregnant status by failure of a fetal skeleton to show on an abdominal X-ray. This was many years ago. This test was claimed to be definitive. One wonders how these women coped thereafter: We agree with the authors that follow-up, not necessarily by a psychiatrist, is important. In the editor's experience pseudocyesis of late pregnancy is less common than advanced true normal pregnancy in a nullipara aged more than 40 years, married for many years, who presents with abdominal pain and finds out to her delighted surprise that she is in labour at term and shortly thereafter produces a surviving normal infant. The reviewers of this paper did not agree with the suggestion that curettage would be an appropriate procedure to convince a woman with pseudocyesis that she was not pregnant. Uowevel; the authors, having read this editorial comment, stated that curettage is mentioned in the pseudocyesis literature (4).

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“…Weight gain (>5 kg) 1 5. Abdominal changes ( t girth, bloating or distention) 1 6. Hyperpigmentation 1 7.…”

Section: Methodsmentioning

confidence: 99%

“…gonadotropins have been reported to be low, normal or high (1)(2)(3)(4)(5)(6). Similarly, basal serum PRL levels have been found elevated or within normal limits (1)(2)(3)(4)(5)(6). However, an exaggerated PRL re¬ sponse to TRH appears to be a common finding in patients with pseudocyesis (1)(2)(3)(4).…”

mentioning

confidence: 99%

Circadian, ultradian, and episodic gonadotropin and prolactin secretion in human pseudocyesis

Bray

Muneyyirci-Delale²,

Kofinas³

et al. 1991

Acta Endocrinologica

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Abstract. Six women with pseudocyesis were studied by 15-min blood sampling for 12 to 24 h to determine their gonadotropin and PRL secretory profiles aiming to clarify the endocrine alterations in this form of hypothalamic amenorrhea. Clinical and biochemical evidence of hyperandrogenism was found in 4 patients. Persistent hyperprolactinemia was present only in one patient. Significant circadian and ultradian periodicities were identified by time series analysis in the 12-24 h profiles of FSH, LH and PRL secretion. Pulse analysis by the Van Cauter (UL-TRA.JN) method revealed a 24-h mean LH interpulse interval of 91±21 min with a mean LH amplitude of 5.4±0.8 IU/l. There was a significantly lower pulse frequency at night than during the daytime. The mean 24-h PRL interpulse interval and pulse amplitude were 134±22 min and 9.2±1.8 IU/l, respectively. Both FSH and LH mean levels were higher during the daytime than at night, while the reverse was true for PRL values. Decreased LH pulse frequeny and amplitude emerged as the most distinctive findings. Antecedent hypothalamic-pituitary aberrations due to other endocrinopathies and the timing of the hormonal assessment (e.g. recovery phase) may explain, at least in part, the reported heterogeneity of neuroendocrinologic findings in pseudocyesis.

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Pituitary function in human pseudocyesis

Cited by 7 publications

References 16 publications

Biopsychosocial view to pseudocyesis: A narrative review

Biopsychosocial view to pseudocyesis: A narrative review

Pseudocyesis and its Modern Perspective

Circadian, ultradian, and episodic gonadotropin and prolactin secretion in human pseudocyesis

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