Pituitary fossa chondrosarcoma: An unusual cause of a sellar suprasellar mass masquerading as pituitary adenoma

Dutta, Gautam; Singh, Daljit; Singh, Hukum; Srivastava, Arvind K.; Jagetia, Anita; Sachdeva, Deepashu

doi:10.4103/sni.sni_455_17

Cited by 8 publications

(1 citation statement)

References 13 publications

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“…Freda et al reported that among 911 cases of sellar lesions, only 83 were non-pituitary lesions, 11% of which were chondrogenic tumors and chordomas 16Table 1Review Of Reported 9 Cases Of Chondrosarcoma In Sellar AreaAuthorAge/SexSize(cm)Clinical PresentationTreatmentFUDing C627/FNAParoxysmal headaches over 1 month and left ptosis for 2 weeksSNAZhang YL720/MNA3 years history of headaches and blurring of vision for one monthSNEDDutta G822/MNAIntermittent headache for past 2 years, diplopia and diminished visual for 3 monthsS&RNEDCao J945/F3.27 months history of amenorrhea and progressive visual loss in the left eye for 3 monthsS&RNEDSharma M1040/F3.5Intermittent headaches for 1year and blurring of visionSNAAidaer1147/F3.08 years history of headaches and blurring of vision for two yearsSNEDYang DB1227/M6.52 years history of headaches and diminished visual acuityS&RNAInenaga C1321/MNADouble vision, right blepharoptosis and facial painS&RDeathAllan CA1437/FNA3 years of generalized headaches and sharp right-sided intermittent retro-orbital pain, blurred of vision in the left eye for 2 years…”

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confidence: 99%

<p>Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review</p>

Zhang

Pang

Wang

et al. 2019

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Low-grade chondrosarcoma (LGC) is a very rare intracranial tumor, particularly in the sellar area. Herein, we describe an unusual case of LGC occurring in the sellar area. A 52-year-old man presented with diminution of vision for more than 3 months, but did not exhibit headaches reported in previous cases. MRI showed that the maximum size of the tumor was 7 cm on the left side of the saddle. We characterized the specific pathological characteristics. Histologically, the tumor had polypoid areas and a lobulated growth pattern under low-power examination. At high magnification, the tumor consisted of small cells with hyperchromatic nuclei in the cartilage matrix, with an alternating loose hypocellular zone and rich myxoid area. In our case, LGC needed to be distinguished from chordoma. Immunohistochemically, the tumor cells showed diffuse positivity for S-100 and vimentin, IDH1 was weakly cytoplasm positive. The Ki-67 labeling index was less than 5%. Additionally, AE1/3, EMA, and CK19 were negative, which could be used to exclude chordoma. This case report expands the literature on LGC and will help clinicians and pathologists better understand this entity.

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Section: Introductionmentioning

confidence: 99%

<p>Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review</p>

Zhang

Pang

Wang

et al. 2019

OTT

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Multi-Dynamic-Multi-Echo-based MRI for the Pre-Surgical Determination of Sellar Tumor Consistency: a Quantitative Approach for Predicting Lesion Resectability

Yildirim,

Schmidbauer,

Micko

et al. 2024

Clin Neuroradiol

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Purpose Pre-surgical information about tumor consistency could facilitate neurosurgical planning. This study used multi-dynamic-multi-echo (MDME)-based relaxometry for the quantitative determination of pituitary tumor consistency, with the aim of predicting lesion resectability. Methods Seventy-two patients with suspected pituitary adenomas, who underwent preoperative 3 T MRI between January 2020 and January 2022, were included in this prospective study. Lesion-specific T1-/T2-relaxation times (T1R/T2R) and proton density (PD) metrics were determined. During surgery, data about tumor resectability were collected. A Receiver Operating Characteristic (ROC) curve analysis was performed to investigate the diagnostic performance (sensitivity/specificity) for discriminating between easy- and hard-to-remove by aspiration (eRAsp and hRAsp) lesions. A Mann-Whitney-U-test was done for group comparison. Results A total of 65 participants (mean age, 54 years ± 15, 33 women) were enrolled in the quantitative analysis. Twenty-four lesions were classified as hRAsp, while 41 lesions were assessed as eRAsp. There were significant differences in T1R (hRAsp: 1221.0 ms ± 211.9; eRAsp: 1500.2 ms ± 496.4; p = 0.003) and T2R (hRAsp: 88.8 ms ± 14.5; eRAsp: 137.2 ms ± 166.6; p = 0.03) between both groups. The ROC analysis revealed an area under the curve of 0.72 (95% CI: 0.60–0.85) at p = 0.003 for T1R (cutoff value: 1248 ms; sensitivity/specificity: 78%/58%) and 0.66 (95% CI: 0.53–0.79) at p = 0.03 for T2R (cutoff value: 110 ms; sensitivity/specificity: 39%/96%). Conclusion MDME-based relaxometry enables a non-invasive, pre-surgical characterization of lesion consistency and, therefore, provides a modality with which to predict tumor resectability.

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Rituximab as a treatment option in a patient with rheumatoid arthritis and a history of malignancy—intracranial chondrosarcoma/osteochondroma—case based review

et al. 2020

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Pituitary fossa chondrosarcoma: An unusual cause of a sellar suprasellar mass masquerading as pituitary adenoma

Cited by 8 publications

References 13 publications

<p>Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review</p>

<p>Low-Grade Chondrosarcoma In The Sellar Area: Case Report And Literature Review</p>

Multi-Dynamic-Multi-Echo-based MRI for the Pre-Surgical Determination of Sellar Tumor Consistency: a Quantitative Approach for Predicting Lesion Resectability

Rituximab as a treatment option in a patient with rheumatoid arthritis and a history of malignancy—intracranial chondrosarcoma/osteochondroma—case based review

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