Pituitary effects of steroid hormones on secretion of follicle-stimulating hormone and luteinizing hormone

Nett, Terry M.; Turzillo, A. M.; Baratta, Mario; Rispoli, Louisa A.

doi:10.1016/s0739-7240(02)00143-1

Cited by 126 publications

(84 citation statements)

References 25 publications

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“…According to the result of some in vitro studies, addition of E 2 inhibited spontaneous secretion of FSH in sheep, pig and cow pituitary cell cultures. The reason for the decrease in FSH secretion, due to the E 2 treatment, had been linked to the suppression of the expression of the gene encoding activin B (Nett et al, 2002). A parallel decrease in concentrations of mRNA for FSH-b subunit and activin-bB was reported.…”

Section: Discussionmentioning

confidence: 99%

“…However, the observed decrease in expression of the activin-bB gene after treatment with E 2 was less than that for FSH-b. Therefore, it was concluded that a relatively smaller reduction in activin concentrations may be sufficient to inactivate the second messenger cascade and thereby greatly reduce FSH synthesis and secretion (Nett et al, 2002). E 2 treatment has no effect on rabbit pituitary cell FSH secretion, whereas it stimulated spontaneous secretion of FSH in rat pituitary cell cultures (Miller and Wu, 1981).…”

Section: Discussionmentioning

confidence: 99%

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Effect of estradiol-17β on follicle-stimulating hormone secretion and egg-laying performance of Japanese quail

Çiftçi

2012

Animal

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The aim of this study was to measure the effect of estradiol-17b (E 2 ) injection on follicle-stimulating hormone (FSH) secretion and egg-laying performance of Japanese quail. Female Japanese quail were housed in cages and fed ad libitum. After a 7-day adaptation period, the birds were randomly assigned to three groups, that is, one control group and two test groups. The birds were weighed, before every injection. The control group was subcutaneously injected with 0.2 ml sesame oil-ethanol mixture, whereas test groups were injected, twice in a week, with 0.2 ml sesame oil-ethanol mixture containing 0.1 or 0.2 mg E 2 along the study. One day after the first injection, egg number, egg weight, eggshell strength and food conception were daily recorded. On the last day of the experiment, the birds were injected and 3 h later seven birds from each group were randomly selected for bleeding. Blood samples (2 ml/bird) were collected from the jugular vein for the measurements of serum concentrations of E 2 , FSH, calcium (Ca) and phosphorus (P). E 2 injection did not cause any significant changes in serum FSH concentrations, daily egg laid/ bird, food conception/bird, serum concentrations of the Ca and the P. Egg weight was significantly increased in the 0.1 mg E 2 -injected group as compared with the control and 0.2 mg E 2 -injected groups. Eggshell strength in the 0.2 mg E 2 -injected group was significantly high as compared with the control, whereas the difference between the 0.1 mg E 2 -and 0.2 mg E 2 -injected groups was not statistically important. These results show that serum FSH concentration was not increased even when slightly suppressed by subcutaneous injection of 0.1 or 0.2 mg E 2 . Different doses of E 2 have different functions. The increase in BWs in the 0.1 mg E 2 -injected group was a result of the dose effect, which probably increased growth hormone secretion from the pituitary or IGF-1 synthesis from the liver or both. The dose, 0.2 mg E 2 , was ineffective in increasing the BW, but it significantly increased eggshell strength probably via the increase in Ca and P utilizations.Keywords: egg, follicle, estradiol, quail ImplicationsThe Japanese quail (Coturnix japonica) belongs to the order Galliformes and the family Phasianidae. They have been used for meat and egg production since 1900. After World War II, the Japanese quail has become an important experimental animal, similar to the mouse and rat, for scientific research in universities. Recently, they have been accepted as a model animal for studying the relationship between the endocrine status and the reproductive behaviors. Not enough data are available about the relationship between serum estradiol-17b (E 2 ) concentration and egg-laying performance of the Japanese quail. A few studies were conducted to measure the effect of intramuscular E 2 benzoate injection on egglaying performance, whereas the majority of other studies mainly focused on the effect of phytoestrogen (daidzein and genistein)-containing diet on the egg-laying performance of the...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of estradiol-17β on follicle-stimulating hormone secretion and egg-laying performance of Japanese quail

Çiftçi

2012

Animal

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“…This has been demonstrated in several species using both in vivo and in vitro models (Lindzey et al 2006, Arreguin-Arevalo et al 2007. Groups using ovine pituitary cells in culture have clearly demonstrated that treatment with E 2 attenuates FSH secretion and intracellular synthesis (Miller et al 1977, Huang & Miller 1980, Nett et al 2002. In particular, E 2 suppresses these parameters by decreasing FSHb expression (Miller & Miller 1996, Baratta et al 2001.…”

Section: Discussionmentioning

confidence: 90%

Effect of phytoestrogens on basal and GnRH-induced gonadotropin secretion

Arispe¹,

Adams²,

Adams³

2013

Journal of Endocrinology

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Plant-derived estrogens (phytoestrogens, PEs), like endogenous estrogens, affect a diverse array of tissues, including the bone, uterus, mammary gland, and components of the neural and cardiovascular systems. We hypothesized that PEs act directly at pituitary loci to attenuate basal FSH secretion and increase gonadotrope sensitivity to GnRH. To examine the effect of PEs on basal secretion and total production of FSH, ovine pituitary cells were incubated with PEs for 48 h. Conditioned media and cell extract were collected and assayed for FSH. Estradiol (E 2 ) and some PEs significantly decreased basal secretion of FSH. The most potent PEs in this regard were coumestrol (CM), zearalenone (ZR), and genistein (GN). The specificity of PE-induced suppression of basal FSH was indicated by the absence of suppression in cells coincubated with PEs and an estrogen receptor (ER) blocker (ICI 182 780; ICI). Secretion of LH during stimulation by a GnRH agonist (GnRH-A) was used as a measure of gonadotrope responsiveness. Incubation of cells for 12 h with E 2 , CM, ZR, GN, or daidzein (DZ) enhanced the magnitude and sensitivity of LH secretion during subsequent exposure to graded levels of a GnRH-A. The E 2 -and PE-dependent augmentation of gonadotrope responsiveness was nearly fully blocked during coincubation with ICI. Collectively, these data demonstrate that selected PEs (CM, ZR, and GN), like E 2 , decrease basal secretion of FSH, reduce total FSH production, and enhance GnRH-A-induced LH secretion in a manner that is dependent on the ER.

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“…This effect is thought to be mediated through the activin/inhibin/follistatin system (DePaolo, 1997;Nett et al, 2002;Welt et al, 2002;McNeilly et al, 2003). Activins are produced by a wide variety of tissues including the pituitary gland, and are specifically by gonadotropes (Roberts et al, 1989).…”

Section: Sirmentioning

confidence: 99%