Pituitary dendritic cells communicate immune pathogenic signals

Glennon, E.; Kaunzner, Ulrike W.; Gagnidze, Khatuna; McEwen, Bruce S.; Bulloch, Karen

doi:10.1016/j.bbi.2015.07.007

Cited by 23 publications

(10 citation statements)

References 43 publications

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“…Germ-free mice appear to exhibit reduced anxiety, however, a finding that runs counter to what would be expected with a hyperactive HPA system (Cryan & Dinan, 2012). Perhaps more clearly suggestive of the potential influence of the enteric microbiota on HPA axis functioning, a recent study found LPS to stimulate the production of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α, and consequently, glucocorticoids (Glennon, Kaunzner, Gagnidze, McEwen, & Bulloch, 2015). Furthermore, administration of probiotics consisting of Lactobacillus spp.…”

Section: Hpa Axismentioning

confidence: 99%

The microbiome as a novel paradigm in studying stress and mental health.

Liu

2017

American Psychologist

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At the intersection between neuroscience, microbiology, and psychiatry, the enteric microbiome has potential to become a novel paradigm for studying the psychobiological underpinnings of mental illness. Several studies provide support for the view that the enteric microbiome influences behavior through the microbiota-gut-brain axis. Moreover, recent findings are suggestive of the possibility that dysregulation of the enteric microbiota (i.e., dysbiosis) and associated bacterial translocation across the intestinal epithelium may be involved in the pathophysiology of stress-related psychiatric disorders, particularly depression. The current article reviews preliminary evidence linking the enteric microbiota and its metabolites to psychiatric illness, along with separate lines of empirical inquiry on the potential involvement of psychosocial stressors, pro-inflammatory cytokines and neuroinflammation, the HPA axis, and vagal nerve activation, respectively, in this relationship. Finally, and drawing on these independent lines of research, an integrative conceptual model is proposed in which stress-induced enteric dysbiosis and intestinal permeability confer risk for negative mental health outcomes through immunoregulatory, endocrinal, and neural pathways.

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Section: Hpa Axismentioning

confidence: 99%

The microbiome as a novel paradigm in studying stress and mental health.

Liu

2017

American Psychologist

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“…www.nature.com/scientificreports/ This present study demonstrated an increase of intraadrenal MHCII-positive cells during the course of collagen type II-induced arthritis. MHCII+ can be present in endocrine glands [16][17][18][19] . Thus, these cells might be important in the observed inadequate glucocorticoid secretion.…”

Section: Discussionmentioning

confidence: 99%

“…In addition to cytokines, under normal and also under pathological conditions, macrophages infiltrate the adrenal cortex of rodents and humans 10 . Interestingly, macrophages and dendritic cells (DCs) are constitutively present in endocrine glands 15 – 19 , and they install an immediate augmentation response upon proinflammatory stimuli to interfere with these glands 18 , 20 . While these before mentioned responsiveness of endocrine glands is physiological in short-lived inflammation, the situation might largely change during a long-standing inflammatory process 21 .…”

Section: Introductionmentioning

confidence: 99%

MHC/class-II-positive cells inhibit corticosterone of adrenal gland cells in experimental arthritis: a role for IL-1β, IL-18, and the inflammasome

Stangl

Krammetsvogl

Lesiak

et al. 2020

Sci Rep

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In experimental arthritis, glucocorticoid secretion is inadequate relative to inflammation. We hypothesized that IL-1 is a key factor for inadequate glucocorticoid secretion in arthritic rats. Collagen type II—induced arthritis (CIA) in DA rats was the model to study effects of IL-1 on adrenal function. In the CIA model, an increase of intraadrenal MHCII-positive cells was observed. MHCII-positive cells or bone marrow-derived dendritic cells inhibited glucocorticoid secretion of adrenal gland cells. IL-1, but also IL-18 and the inflammasome were critical in glucocorticoid inhibition. Arthritic compared to control adrenal gland cells produced higher amounts of CXC chemokines from MHCII+ adrenal cells, particularly CINC-2, which is strongly dependent on presence of IL-1. In CIA, macrophages and/or dendritic cells inhibit glucocorticoid secretion via IL-1 in adrenal glands. These findings show that activated macrophages and/or dendritic cells inhibit glucocorticoid secretion in experimental arthritis and that IL-1β is a decisive factor.

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“…Additionally, studies of transgenic mice that express fluorescent protein markers for monocytic cells, in particular DC, clearly showed the presence of these leukocytes traversing discrete regions of the steady-state brain (Figure 1 ) ( 5 ). In multiple studies examining various immune challenges, results show that this EYFP + cell population is comprising both peripherally and centrally derived monocytic cells with diverse functions ( 6 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS

et al. 2016

Self Cite

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Epigenetic alterations are necessary for the establishment of functional and phenotypic diversity in the populations of immune cells of the monocytic lineage. The epigenetic status of individual genes at different time points defines their transcriptional responses throughout development and in response to environmental stimuli. Epigenetic states are defined at the level of DNA modifications, chromatin modifications, as well as at the level of RNA base changes through RNA editing. Drawing from lessons regarding the epigenome and epitranscriptome of cells of the monocytic lineage in the periphery, and from recently published RNAseq data deriving from brain-resident monocytes, we discuss the impact of modulation of these epigenetic states and how they affect processes important for the development of a healthy brain, as well as mechanisms of neurodegenerative disease and aging. An understanding of the varied brain responses and pathologies in light of these novel gene regulatory systems in monocytes will lead to important new insights in the understanding of the aging process and the treatment and diagnosis of neurodegenerative disease.

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Pituitary dendritic cells communicate immune pathogenic signals

Cited by 23 publications

References 43 publications

The microbiome as a novel paradigm in studying stress and mental health.

The microbiome as a novel paradigm in studying stress and mental health.

MHC/class-II-positive cells inhibit corticosterone of adrenal gland cells in experimental arthritis: a role for IL-1β, IL-18, and the inflammasome

Epigenetic Modulators of Monocytic Function: Implication for Steady State and Disease in the CNS

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