Pituitary Corticotroph Macrotumors

Ihle, Sherri L.

doi:10.1016/s0195-5616(97)50032-5

Cited by 18 publications

(19 citation statements)

References 33 publications

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“…10 mm in diameter. 7 In the present study, we found that neurologic signs could develop in dogs with tumors as small as 3 mm in height, but these neurologic signs occurred in a single dog that developed seizures. There may or may not have been an association between the visualized mass and the seizure disorder, but seizures developed 2 days before imaging.…”

Section: Discussioncontrasting

confidence: 41%

“…7 Approximately 10% of dogs with pituitary masses have clinically nonfunctional tumors. 1,7 MR imaging (MRI) and CT are the only antemortem, noninvasive methods for determining the presence and size of a pituitary mass. 8,9 In humans, pituitary tumors .10 mm in height are classified as macroadenomas.…”

mentioning

confidence: 99%

“…Up to 30% of dogs with PDH have pituitary tumors large enough to result in mass-related clinical signs within several months of diagnosis of hyperadrenocorticism. 7 Approximately 10% of dogs with pituitary masses have clinically nonfunctional tumors. 1,7 MR imaging (MRI) and CT are the only antemortem, noninvasive methods for determining the presence and size of a pituitary mass.…”

mentioning

confidence: 99%

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Survival, Neurologic Response, and Prognostic Factors in Dogs with Pituitary Masses Treated with Radiation Therapy and Untreated Dogs

Kent

Bommarito

Feldman

et al. 2007

Veterinary Internal Medicne

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Background: Pituitary masses in dogs are not uncommon tumors that can cause endocrine and neurologic signs and, if left untreated, can decrease life expectancy.Hypothesis: Dogs with pituitary masses that received radiation therapy (RT) have more favorable neurologic outcomes and longer survival times compared with untreated dogs.Animals: Nineteen dogs with a pituitary mass identified on CT or MR imaging were irradiated with 48 Gy given in 3 Gy daily-dose fractions. Twenty-seven untreated control dogs had pituitary masses.Methods: Medical records of dogs with pituitary masses were retrospectively reviewed for clinical signs, mass size, and outcome.Results: Median survival time was not reached in the treated group. Mean survival time in the treated group was 1,405 days (95% confidence interval [CI], 1,053-1,757 days) with 1-, 2-, and 3-year estimated survival of 93, 87, and 55%, respectively. Median survival in the nonirradiated group was 359 days (95% CI, 48-916 days), with a mean of 551 days (95% CI, 271-829 days). The 1-, 2-, and 3-year estimated survival was 45, 32, and 25%, respectively. Dogs that received RT for their pituitary tumors had significantly longer survival times than untreated dogs (P 5 .0039). Treated dogs with smaller tumors (based on maximal pituitary-to-brain height ratio or area of tumor to area of brain) lived longer than those with larger tumors (P , .001).Conclusions and Clinical Importance: When compared with untreated dogs, RT increased survival and controlled neurologic signs in dogs with pituitary masses.

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Section: Discussioncontrasting

confidence: 41%

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confidence: 99%

mentioning

confidence: 99%

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Survival, Neurologic Response, and Prognostic Factors in Dogs with Pituitary Masses Treated with Radiation Therapy and Untreated Dogs

Kent

Bommarito

Feldman

et al. 2007

Veterinary Internal Medicne

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“…For thrombosis, heparin sodium (100 IU/kg, sc, BID for 18 days) and dipyridamole (1.25-1.5 mg/kg, po, SID-ter in die (TID)) were continued before and after the operation. In addition, after hypophysectomy, hormone replacement therapy was initiated with desmopressin acetate (DDAVP; Desmopressin, Kyowa Hakko Kogyo Co., Ltd., Japan) (0.1-0.2 µg/kg for eye drops, SID-BID), hydrocortisone sodium phosphate (Hydrocortone, Banyu Pharmaceutical Co., Ltd., Japan) (1 mg/kg, iv, TID for 3 days after the operation), prednisolone (Predonine, Shionogi & Co., Ltd., Japan) (0.25-0.5 µg/kg, po, BID) and levothyroxine sodium (Thyradin-S, Aska Pharmaceutical Co., Ltd., Japan) (20-25 µg/kg, po, BID) [15,16,23,24].…”

mentioning

confidence: 99%

Cushing's Disease Complicated with Thrombosis in a Dog

Teshima

Hara

Taoda

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. Thrombosis is a potential complication of hyperadrenocorticism (HAC) in dogs. An 8-year-old male Beagle diagnosed with pituitary-dependent HAC had complicated with thrombosis in the caudal vena cava and abdominal aorta, which was treated by hypophysectomy and antithrombotic therapy. After hypophysectomy, hypercortisolemia disappeared and the general condition was also significantly improved. Ultrasonography after hypophysectomy revealed that the thrombus remained in the abdominal aorta, but the thrombus in the caudal vena cava had disappeared. However 692 days after the hypophysectomy, the dog had an acute onset of dyspnea and died. Postmortem examination revealed the presence of thrombi in the abdominal aorta and the pulmonary artery. Observations from this case show that HAC dogs must be attention to thrombosis. KEY WORDS: canine, hyperadrenocorticism, thrombosis.

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“…Around 75% of patients achieve long-term cure, but the remainder of patients experience disease recurrence or residual disease post-surgery (Hanson et al, 2005). Additionally, there is a reasonable chance (approximately 20%) that without surgery the pituitary tumour will grow large enough to cause clinical signs and shortened life span (Kipperman et al, 1992;Bertoy et al, 1996;Ihle, 1997;Kent et al, 2007).…”

Section: Surgical Managementmentioning

confidence: 99%