Pituitary Apoplexy in Acromegaly Followed by Partial Pituitary Insufficiency

Amelioration of Acromegaly after Pituitary Infarction Due to Gastrointestinal Hemorrhage from Gastric Ulcer.

“…Pituitary apoplexy usually occurs spontaneously since the blood supply to a tumor is precarious, but it has been described in association with a great variety of events, including minor head trauma [3], medications [1], and dynamic pituitary function test [9,10], although the mechanism leading to apoplexy is obscure in most of these events. This patient presumably had massive bleeding from an acute gastric ulcer.…”

A case of pituitary apoplexy with spontaneous recovery.

“…It has been reported that the inducement of pituitary apoplexy was the irradiation of pituitary tumor, diabetic ketoacidosis, trauma, pneumoencephalography, hypoglycemia, estrogen therapy, anticoagulant therapy and narcotic addiction, etc (Jacobi et al, 1974). It is also well known that tumors which undergo apoplexy are usually eosinophilic and chromophobe adenomas (Brougham et al, 1950).…”

“…These facts suggested that hypopituitarism was not present or was partially, if any, before the attack. It has been well recognised that a permanent or transient hypopituitarism including DI may occur with pituitary apoplexy (Brougham eI al., 1950;Taylor et al, 1968;Epstein t al., 1971;Jacobi et al, 1974) and that in some cases of acromegaly and ForbesAlbright syndrome (Forbes et al, 1954), the regression of the disease was observed after apoplexy (Taylor et al, 1968;McLaren et al, 1973;Jacobi et al, 1974). However, it has scarecely been reported that systematic evaluations of the pituitary Vol.25,No.3 PITUITARY APOPLEXY function using synthetic hypothalamic hormones, TRH and LHRH, and direct measurements of several trophic hormones were performed successively during the spontaneous recovery course.…”

“…of Medicine, Mibu, Tochigi 321-02, Japan Since the original report by Bleibtrau (1905) and the comprehensive study by Brougham et al (1950), many cases of pituitary apoplexy have been reported and the interests from neurosurgical and endocrinological points of view have increased (Krueger et al, 1960;Wright et al, 1965;Taylor et al, 1968;Epstein et al, 1971;Rovit et al, 1972;Jacobi et al, 1974). The tumors of the pituitary which undergo apoplexy are usually chromophobe and eosinophilic adenoma with disproportionate frequency in the less common latter (Brougham et al, 1950).…”

“…The tumors of the pituitary which undergo apoplexy are usually chromophobe and eosinophilic adenoma with disproportionate frequency in the less common latter (Brougham et al, 1950). The effect of apoplexy on pituitary function results in permanent or transient hypopituitarism including diabetes insipidus (Brougham et al, 1950;Taylor et al, 1968;Epstein et al, 1971;Jacobi et al, 1974). However, the detailed endocrine study has been scant during the spontaneous recovery course following the attack.…”