Pituitary-Adrenal Function in Acute Falciparum Malaria *,†

Brooks, Marion H.; Barry, Kevin G.; Cirksena, William J.; Malloy, John P.; Bruton, Joseph D.; Gilliland, Paul F.

doi:10.4269/ajtmh.1969.18.872

Cited by 24 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies have demonstrated that malaria patients receiving quinine and pyrimethamine have normal plasma cortisol levels, measured both isotopically and as Porter-Silber chromogens, and respond normally to Metopirone. 4 These findings suggest that these drugs do not significantly alter pituitary or adrenal function.…”

Section: Discussionmentioning

confidence: 94%

Effect of antimalarial drugs and collection methods on urinary and plasma 17‐hydroxycorticosteroid determinations

Gilliland¹,

Brooks²,

Bruton³

et al. 1969

Clin Pharma and Therapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 94%

Effect of antimalarial drugs and collection methods on urinary and plasma 17‐hydroxycorticosteroid determinations

Gilliland¹,

Brooks²,

Bruton³

et al. 1969

Clin Pharma and Therapeutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Importantly, some old studies investigated the responsiveness of the HPA axis after infection with P. falciparum through suppression and activation tests, as reviewed previously ( 7 ). In UM, the HPA axis was found to be intact but in SM, the pituitary secretion of ACTH was suboptimal ( 28 , 29 ). In addition to the ACTH-driven release of cortisol, reduced enzymatic breakdown of cortisol in liver and kidney might increase circulatory levels of cortisol.…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoid dysfunction in children with severe malaria

Vandermosten,

Prenen,

Fogang

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

IntroductionMalaria remains a widespread health problem with a huge burden. Severe or complicated malaria is highly lethal and encompasses a variety of pathological processes, including immune activation, inflammation, and dysmetabolism. Previously, we showed that adrenal hormones, in particular glucocorticoids (GCs), play critical roles to maintain disease tolerance during Plasmodium infection in mice. Here, GC responses were studied in Cameroon in children with uncomplicated malaria (UM), severe malaria (SM) and asymptomatic controls (AC).MethodsTo determine the sensitivity of leukocytes to GC signaling on a transcriptional level, we measured the ex vivo induction of glucocorticoid induced leucine zipper (GILZ) and FK506-binding protein 5 (FKBP5) by GCs in human and murine leukocytes. Targeted tracer metabolomics on peripheral blood mononuclear cells (PBMCs) was performed to detect metabolic changes induced by GCs. ResultsTotal cortisol levels increased in patients with clinical malaria compared to AC and were higher in the SM versus UM group, while cortisol binding globulin levels were unchanged and adrenocorticotropic hormone (ACTH) levels were heterogeneous. Induction of both GILZ and FKBP5 by GCs was significantly reduced in patients with clinical malaria compared to AC and in malaria-infected mice compared to uninfected controls. Increased activity in the pentose phosphate pathway was found in the patients, but this was not affected by ex vivo stimulation with physiological levels of hydrocortisone. Interestingly, hydrocortisone induced increased levels of cAMP in AC, but not in clinical malaria patients. DiscussionAltogether, this study shows that patients with SM have increased cortisol levels, but also a decreased sensitivity to GCs, which may clearly contribute to the severity of disease.

show abstract

“…Brookes et al (1969) found raised serum cortisol with normal diurnal variation in malaria patients of unspecifi ed severity. 4 Serum cortisol level has been reported to be higher in uncomplicated malaria than healthy controls by Wilson et al (2001). 5 Davis et al (1997) found that the basal serum cortisol in patients of severe falciparum malaria was signifi cantly higher than those of uncomplicated cases.…”

Section: Introductionmentioning

confidence: 96%

Study of serum cortisol level in severe falciparum malaria presenting with unexplained hypotension

Pradhan¹,

Khadanga

Padhiary

et al. 2014

Asian J Med Sci

View full text Add to dashboard Cite

Background: Hypotension in malaria can be due to various causes. One among them is relative adrenal deficiency. World Health Organisation (WHO) and Indian malaria guidelines do not allow the use of steroid in malaria patients. But it appears prudent to use systemic steroid in those subset of malaria patients having adrenal deficiency. So the aim of the study was to prove or disprove the existence of adrenal deficiency in malaria patients. Methodology: This is a case control study which was conducted in two tertiary care centres, single blind and prospective in nature. SPSS 19 was used at the end of the study for all statistical analysis. Patient characteristics and outcome of interest is calculated with 95% confidence limits. The probability of <0.05 is considered to be significant. Results: Compared with control group the study group had significantly lower serum cortisol level at presentation (36.56±6.52 µg/dl vs. 19.43±7.29 µg/dl, p=0.006). In the study group there is significant rise in serum cortisol level after recovery from hypotension (19.96±7.29 µg/dl vs. 35.86±8.26 µg/dl, p=0.01). In control group there is slight decrease of serum cortisol level after recovery (36.85±6.42 µg/dl vs. 34.72±9.12 µg/dl, p=0.83). Conclusion: Adrenal insufficiency may be the cause of unexplained hypotension in severe falciparum malaria. Administration of systemic corticosteroid in this subset of patients seems to be justified.DOI: http://dx.doi.org/10.3126/ajms.v6i3.11282Asian Journal of Medical Sciences Vol.6(3) 2015 30-32

show abstract

Pituitary-Adrenal Function in Acute Falciparum Malaria *,†

Cited by 24 publications

References 0 publications

Effect of antimalarial drugs and collection methods on urinary and plasma 17‐hydroxycorticosteroid determinations

Effect of antimalarial drugs and collection methods on urinary and plasma 17‐hydroxycorticosteroid determinations

Glucocorticoid dysfunction in children with severe malaria

Study of serum cortisol level in severe falciparum malaria presenting with unexplained hypotension

Contact Info

Product

Resources

About