Pituitary-Adrenal Function During Corticosteroid Therapy

Treadwell, B. L. J.; Savage, Oswald; Sever, Emily; Copeman, W. S. C.

doi:10.1016/s0140-6736(63)91383-7

Cited by 77 publications

(29 citation statements)

References 14 publications

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“…Our rats were given the same total dose of betamethasone over different periods and the effects on the endocrine system were different. The total dose alone appeared not to be of prime importance in this respect, in contrast to the findings of Treadwell et al (1963) and-Landon et al (1965). Since the steroid was administered in the drinking water it attained high blood levels only infrequently, if at all.…”

Section: Discussionmentioning

confidence: 75%

“…Hypothalamo-pituitary-adrenal (HPA) activity may be impaired in patients on corticosteroids (Landon, Wynn, James & Wood, 1965;Shuster & Williams, 1961;Treadwell, Savage, Sever & Copeman, 1963). The impairment may persist and result in serious adrenocortical insufficiency in a stressful situation such as surgery (Carreon, Canary, Meyer & Kyle, 1960;Salassa, Bennett, Keating & Sprague, 1953;Sampson, Winstone & Brooke, 1962).…”

Section: Introductionmentioning

confidence: 99%

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Recovery of hypothalamo‐pituitary‐adrenal function in the rat after prolonged treatment with betamethasone

Hodges

Mitchley

1970

British J Pharmacology

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Summary1. Betamethasone caused growth retardation, adrenal atrophy and impaired hypothalamo-pituitary-adrenal (HPA) activity in the rat. 2. In spite of the profound impairment, recovery of normal HPA function was rapid, but the growth retardation persisted.3. The ability of the pituitary gland to secrete basal corticotrophin (ACTH), recovered more rapidly and the adrenocorticotrophic response to stress less rapidly than the ability of the adrenal cortex to respond to ACTH. 4. The degree of HPA suppression was not determined by the total dose of steroid. 5. The possible significance of the results is discussed.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Recovery of hypothalamo‐pituitary‐adrenal function in the rat after prolonged treatment with betamethasone

Hodges

Mitchley

1970

British J Pharmacology

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“…During oral steroid therapy in low doses one finds low 17-KGS, a low plasma cortisol level, an unresponsiveness to metyrapone and an unrespon siveness to insulin-induced hypoglycaemia [10][11][12], Normalization of the pituitary adrenocortical function takes place in these cases within 1 month after discontinuing the therapy [13].…”

Section: Discussionmentioning

confidence: 99%

Adrenal and Pituitary Functions during Long-Term Topical Steroid Therapy

Hendrikse¹,

Moolenaar²

1972

Dermatology

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The results of investigations in 6 psoriasis patients, who have been treated with corticosteroid ointments (15–50 g daily) under occlusive dressings over a long period (minimum of 2 till more than 5 years) on the consequences of this therapy for the pituitary-adrenocortical system are related. In accordance with the literature a systemic effect during therapy is evident by a lowering of the 17-ketogenic steroids in the 24-hour urine and the plasma cortisol levels, and in an insufficient reaction to metyrapone. Stimulation with exogenous ACTH was followed by a normal adrenocortical response in all patients. With the insulin-tolerance test a good reaction to stress during therapy is found in the 5 tested patients. It is plausible, therefore, that the feedback system will resume its responsiveness after discontinuing the local therapy and that the suppression does not indicate permanent damage to the pituitary adrenal functions.

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“…[70][71][72][73][74] However, high-dose corticosteroid therapy and prolonged treatment do not invariably correlate with the degree and duration of hypothalamic-pituitary-adrenal suppression, 72,73,75,76 and the time to recovery after discontinuation of corticosteroid therapy is highly variable. It can be as short as two to five days 76 or as long as nine months to one year.…”

Section: Patients With Chronic Autoimmune or Inflammatory Diseases Trmentioning

confidence: 99%