Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide promote the genesis of calcium currents in differentiating mouse embryonic stem cells

CHAFAI, M.; Basille, Magali; Galas, Ludovic; Rostène, William; Gressèns, Pierre; Vaudry, Hubert; Gonzalez, Bruno J.; Louiset, Estelle

doi:10.1016/j.neuroscience.2011.09.062

Cited by 9 publications

(4 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both peptides stimulate neurite outgrowth and NSE overexpression after 4-8 days treatment [64]. This is associated with an enhancement of T-type calcium currents [65] correlated with a stronger expression of Cav3.3 protein as observed in western-blot experiments.…”

Section: Expression Of Voltage-dependent Calcium Channelsmentioning

confidence: 55%

Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation

Warnier¹,

Gackière²,

Roudbaraki³

et al. 2017

J Cell Signal

View full text Add to dashboard Cite

Neuroendocrine cells release their secretion into the extracellular environment through calcium-dependent signalling pathways. These cells share common morphological and molecular features such as the expression of specific biomarkers, neurite outgrowth and dense core secretory granules. In order to elucidate the signalling pathways leading from undifferentiated to differentiated neuroendocrine cells, the role of voltage-dependent calcium channels, central actors in the excitation-secretion coupling, has been comprehensively investigated. T-type calcium channels appear to belong to the most important ion channel family involved in the neuroendocrine differentiation process. They could also participate in the development of neuroendocrine tumours.

show abstract

Section: Expression Of Voltage-dependent Calcium Channelsmentioning

confidence: 55%

Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation

Warnier¹,

Gackière²,

Roudbaraki³

et al. 2017

J Cell Signal

View full text Add to dashboard Cite

show abstract

“…Previous publications have shown that this substance enhances the survival rate of nerve cells subjected to various pathological factors 58 . VIP has also been found to be involved in early embryonic development 60 , differentiation of embryonic stem cells 61 and control of regulatory processes related to mitosis, differentiation and survival of neuroblasts in cell cultures 62 . VIP also inhibits the development of neurodegenerative diseases 63 .…”

Section: Discussionmentioning

confidence: 99%

Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone

Makowska

Lech²,

Majewski

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Bisphenol A (BPA) is used in the production of plastics approved for contact with feed and food. Upon entering living organisms, BPA, as a potent endocrine disruptor, negatively affects various internal organs and regulatory systems, especially in young individuals. Although previous studies have described the neurotoxic effects of BPA on various tissues, it should be underlined that the putative influence of this substance on the chemical architecture of the urinary bladder intrinsic innervation has not yet been studied. One of the most important neuronal substances involved in the regulation of urinary bladder functions is vasoactive intestinal polypeptide (VIP), which primarily participates in the regulation of muscular activity and blood flow. Therefore, this study aimed to determine the influence of various doses of BPA on the distribution pattern of VIP-positive neural structures located in the wall of the porcine urinary bladder trigone using the double-immunofluorescence method. The obtained results show that BPA influence leads to an increase in the number of both neurons and nerve fibres containing VIP in the porcine urinary bladder trigone. This may indicate that VIP participates in adaptive processes of the urinary bladder evoked by BPA.

show abstract

“…The discrepancy between the actions of PACAP and VIP may result from the fact that PACAP activates both the VPAC and PAC receptors whereas VIP only binds to VPAC receptors with high affinity. Indeed, it has been proposed that VPAC and PAC receptors may mediate opposite biological effects in some models [41], their concomitant activation by PACAP having therefore no significant influence on the activity of the target tissue. Taken together, these data suggest that circulating glucagon may be able to activate glucocorticoid secretion by some cortisolsecreting BMAHs and unilateral adenomas in fasting conditions, supplying therefore plasma ACTH, which is suppressed by cortisol excess.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Sensitivity to Glucagon and Related Peptides in Primary Adrenal Cushing’s Syndrome

et al. 2014

Self Cite

View full text Add to dashboard Cite

Illegitimate G-protein coupled receptors are known to control cortisol secretion in adrenal adenomas and bilateral macronodular adrenal hyperplasias (BMAHs) causing Cushing's syndrome. In the present study, we have evaluated the role of glucagon in the regulation of cortisol secretion in 13 patients with BMAH or adrenocortical adenoma causing subclinical or overt Cushing's syndrome. Injection of glucagon provoked an increase in plasma cortisol in 2 patients. After surgery, immunohistochemical studies showed the presence of glucagon receptor-like immunoreactivity in clusters of spongiocytic cells in adrenal tissues from patients who were sensitive in vivo to glucagon. We also observed an in vitro cortisol response to vasoactive intestinal peptide from an adenoma, which was insensitive to glucagon and pituitary adenylate cyclase-activating peptide. Altogether, our data show that ectopic glucagon receptors are expressed in some adrenal cortisol-producing benign lesions. Our results also indicate that circulating glucagon may influence cortisol release under fasting conditions.

show abstract

Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide promote the genesis of calcium currents in differentiating mouse embryonic stem cells

Cited by 9 publications

References 78 publications

Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation

Expression and Role of T-type Calcium Channels during Neuroendocrine Differentiation

Bisphenol A affects vipergic nervous structures in the porcine urinary bladder trigone

Abnormal Sensitivity to Glucagon and Related Peptides in Primary Adrenal Cushing’s Syndrome

Contact Info

Product

Resources

About