Pituitary Adenomas and Granular Cell Tumors: Incidence, Cell Type, and Location of Tumor in 100 Pituitary Glands at Autopsy

Tomita, Tatsuo; Gates, E

doi:10.1093/ajcp/111.6.817

Cited by 78 publications

(51 citation statements)

References 8 publications

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“…19 They are usually asymptomatic but, if they grow, they can compress the gland, the optic chiasm or the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

Histopathological features of post-mortem pituitaries: A retrospective analysis

Tortosa¹,

Fernández

2016

Rev. Assoc. Med. Bras.

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Objective: As a result of the use of neuroimaging techniques, silent pituitary lesions are diagnosed more and more frequently; however, there are few published post-mortem studies about this gland. Incidence data of pituitary lesions are rare and in Portugal they are outdated or even non-existent. The aim of this study is to determine the prevalence of normal patterns and incidental post-mortem pituitary pathology at Centro Hospitalar Lisboa Norte, analyzing the associations with clinical data and assessing the clinical relevance of the findings. Method:We reviewed retrospectively and histologically 167 pituitaries of a consecutive series of autopsies from the Department of Pathology of this centre. They were done between 2012 and 2014, and in all cases medical records were reviewed. The morphological patterns observed, were classified into three major groups: 1) Normal histological patterns and variants; 2) Infectious-inflammatory pathology, metabolic and vascular disorders; 3) Incidental primary proliferation and secondary to systemic diseases. Results:The subjects included in this study were of all age groups (from 1 day to 91 years old), 71 were female and 96 male. Fifty-seven of these glands didn't show any alteration; 51 showed colloid cysts arising from Rathke cleft; 44 presented hyperplasia in adenohypophysis and we identified 20 adenomas in 19 glands (immunohistochemically, eight PRL-producing and five ACTH-producing tumors), ten of which associated with obesity, 11 to hypertension and six to diabetes mellitus. There were two cases with metastasis. Conclusion: Subclinical pathology in our country is similar to that seen in other parts of the world, but at older ages.

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“…19 They are usually asymptomatic but, if they grow, they can compress the gland, the optic chiasm or the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

Histopathological features of post-mortem pituitaries: A retrospective analysis

Tortosa¹,

Fernández

2016

Rev. Assoc. Med. Bras.

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“…Reported CNS tumors with granular cell or oncocytic change include: astrocytoma, medulloblastoma, ganglioglioma, glioblastoma, meningioma, schwannoma, ependymoma, oligodendroglioma, neurofibroma, anterior and posterior pituitary [2][3][4][5][6][7]. Spindle cell oncocytoma, granular cell astrocytoma, and pituicytoma are distinct entities and possibly the infundibular granular cell tumor as well.…”

Section: Wwwijcasereportsandimagescommentioning

confidence: 99%

Granular tumors of the central nervous system: A case series

Trimaldi¹,

Riddle²,

Bowers³

et al. 2013

IJCRI

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“…Although these tumors are usually asymptomatic, there have been several reports which have characterized the clinical presentation of this tumor. [23][24][25] They are seen in adults with a female predominance (2:1 ratio). Symptoms develop insidiously and include hormonal and visual disturbances and bitemporal hemianopia.…”

Section: Sellarmentioning

confidence: 99%

Granular cell tumor of the neurohypophysis: Report of a case with intraoperative cytologic diagnosis

Policarpio‐Nicolas

Mandell

et al. 2007

Diagnostic Cytopathology

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Cytological techniques including touch and smear preparations are very useful diagnostic modality in the evaluation of central nervous system (CNS) lesions and, in many instances, may be effectively used as the sole modality of tissue preparation for intraoperative consultation. Cytologic preparations offer many advantages over frozen sections for CNS specimens. These include selective examination of multiple areas from small biopsy specimens, superior preservation and details of cellular morphology, fewer artifacts, faster results, and improved costeffectiveness. We describe the cytologic diagnosis of a granular cell tumor (GCT) of the neurohypophysis in a 33-year-old male who presented with headache and blurred vision. CT scan revealed an enlarged sella with a 2.15 3 2.0 cm pituitary lesion. Transsphenoidal resection of the mass was performed and submitted for intraoperative consultation. Smears and touch preparations were made on a portion of the mass that showed uniform polygonal cells with round to ovoid nuclei and abundant eosinophilic granular cytoplasm. An intraoperative cytological diagnosis of ''favor GCT'' was rendered. The histologic sections of the remaining material confirmed the diagnosis. Although GCT of the neurohypophysis is very rare, a specific intraoperative cytological diagnosis is possible. We report the clinical, cytological, and pathological findings of a GCT affecting the neurohypophysis. Diagn. Cytopathol. 2008;36:58-63. ' 2007 Wiley-Liss, Inc.Key Words: granular cell tumor; neurohypophysis; intraoperative smear preparation Granular cell tumors (GCTs) have been reported in many sites of the body including the breast, skin, and larynx. However, head and neck have been the most common sites. GCT has a distinctive appearance on cytology, so that it has been suggested to be an effective method for accurate diagnosis even though some reports focus on the difficulties in cytological differential diagnosis. [1][2][3][4][5][6] Within the central nervous system (CNS), GCTs usually occur as intrasellar and/or suprasellar mass arising from the neurohypophysis or infundibulum. On histologic sections and cytological smears, GCT is composed of nests of large cells with small round to oval nucleus and abundant granular eosinophilic cytoplasm, arranged as individual cells or in clusters. Although the cytology of GCT in other sites has been reported in the English literature, 7-17 to our knowledge, there has been no report on the intraoperative touch/squash cytology of this tumor. We report the first case of GCT of the neurohypophysis diagnosed on cytological preparations during an intraoperative consultation, illustrating the value of intraoperative cytology as a well recognized and reliable diagnostic modality for rapid interpretation and even classification of neuropathologic specimens. Case ReportThe patient is a 33-year-old male with history of progressively worsening headache for 2 years. He presented to our hospital for fever, severe headache, nausea, vomiting, and blurred vision. Cerebrospinal...

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Pituitary Adenomas and Granular Cell Tumors: Incidence, Cell Type, and Location of Tumor in 100 Pituitary Glands at Autopsy

Cited by 78 publications

References 8 publications

Histopathological features of post-mortem pituitaries: A retrospective analysis

Histopathological features of post-mortem pituitaries: A retrospective analysis

Granular tumors of the central nervous system: A case series

Granular cell tumor of the neurohypophysis: Report of a case with intraoperative cytologic diagnosis

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