Pituicytoma Associated with Acromegaly and Cushing Disease

Pont, Francisco Marcó del; Villalonga, Juan F.; Ries-Centeno, Tomas; Arakaki, Naomí; Katz, Débora; Cervio, Andrés

doi:10.1016/j.wneu.2019.12.085

Cited by 8 publications

(5 citation statements)

References 15 publications

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“…Moreover, according to our review the enhancement was different in five reported cases and one author reported a patient with cavernous sinus invasion. 18 Particularly in our case, the patient had two macroadenomas with no enhancement and the only difference among them was that the posterior tumor appeared hyperintense on T2WI sequences. There is only one other reported case with a preoperative MRI showing two separate tumors in the sella turcica.…”

Section: Discussionmentioning

confidence: 53%

“…8 In our comprehensive review, we found eight cases of TTF-1 pituitary tumors associated with increased serum hormones. 7,9,18,19,[22][23][24][25] Hypercortisolism with increased ACTH serum values was reported in five patients and acromegaly with increased GH serum values appeared in two cases. Interestingly and according to our review, the histological finding of the pituitary adenoma or the cause of the serum hormone levels could not be determined in some of the reported cases of TTF-1 tumors.…”

Section: Discussionmentioning

confidence: 99%

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Synchronous Posterior and Anterior Pituitary Tumors: A Case Report of a Hypothetic Paracrine Relationship

et al. 2023

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Tumors of the posterior pituitary are a distinct group of low-grade sellar neoplasms. Furthermore, the coexistence with an anterior pituitary tumor is extremely unlikely and could not be a mere coincidence and could be a paracrine relationship. Here, we present a case of 41-year-old woman with Cushing syndrome and two pituitary masses on magnetic resonance imaging. Histologic examination shows two distinct lesions. The first consisted of a pituitary adenoma with intense adrenocorticotropic hormone immunostaining and the second lesion consisted of a proliferation of pituicytes arranged in vague fascicles or pituicytoma. After a narrative review of the literature, we found that synchronous pituitary adenoma and a thyroid transcription factor 1 (TTF-1) pituitary tumor were only reported eight times in the past. These patients included two granular cell tumors and six pituicytomas and all of them coexisted with pituitary adenomas, seven functioning and one nonfunctioning. We analyze the hypothesis of a possible paracrine relationship for this concomitance, but this exceedingly rare situation is still a matter of debate. To the best of our knowledge, our case represents the ninth case of a TTF-1 pituitary tumor coexisting with a pituitary adenoma.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Synchronous Posterior and Anterior Pituitary Tumors: A Case Report of a Hypothetic Paracrine Relationship

et al. 2023

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“…Few studies have reported other hormonal disturbances in patients diagnosed with pituicytoma such as Cushing syndrome as found through a detailed PubMed literature search. These hormonal defects are mainly due to a mass effect [ 4 , 5 , [15] , [16] , [17] , [18] , [19] ].…”

Section: Discussionmentioning

confidence: 99%

A rare case of pituicytoma-related hyperprolactinemia due to mass effect on infundibular stalk—Case report

Al-Salihi,

Ahmed,

Al-Jebur

et al. 2023

International Journal of Surgery Case Reports

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“…Some endocrine alterations, such as anterior pituitary hormone deficit, mild hyperprolactinemia, and diabetes insipidus, can be explained by the mass effect or stalk effect of posterior pituitary tumors (PPTs) [ 2 , 3 ]. However, remarkable pituitary hyperfunction disorders, mostly Cushing’s disease (CD), have also been reported in 17 patients [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ], most of whom had a suspected diagnosis of pituitary adenoma before surgery. In patients presenting with biochemical CD, concurrent adrenocorticotropin (ACTH)-secreting adenoma or hyperplasia was occasionally evidenced in histopathological examinations [ 4 , 7 , 9 , 14 , 15 ], but mostly, only pituicytoma was identified.…”

Section: Introductionmentioning

confidence: 99%

Pituicytoma Associated with Suspected Cushing’s Disease: Two Case Reports and a Literature Review

Xiao

Duan

Chen

et al. 2022

JCM

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(1) Background: Pituicytomas are rare gliomas located in the neurohypophysis or infundibulum. A misdiagnosis of pituicytoma as pituitary adenoma is common because of similar location and occasional endocrine disturbances. (2) Case presentation: We present two cases with the comorbidity of pituicytoma and Cushing’s disease (CD). Case 1 is that of a 51-year-old woman, the first reported case of the comorbidity of pituicytoma, CD, and central diabetes insipidus. She received a diagnosis of CD and central diabetes insipidus. After transsphenoidal surgery, histopathology confirmed the diagnosis of pituicytoma and adrenocorticotropin-secreting microadenoma; case 2 is that of a 29-year-old man who received a biochemical diagnosis of CD, but he received a histopathological confirmation of only pituicytoma. Both patients achieved a remission of hypercortisolism without relapse during the follow-up, but they developed hypopituitarism after surgery. We also reviewed all published 18 cases with the comorbidity of pituicytoma and any pituitary adenoma. (3) Conclusions: Pituicytoma might present pituitary hyperfunction disorders such as CD or acromegaly, with or without pathologically confirmed pituitary adenoma. CD is the most common hyperpituitarism occurring concurrently with pituicytomas. The remission rate and hypopituitarism after surgery seem similar or slightly lower in CD than in common pituitary adenomas, but the long-term prognosis is unexplored.

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Pituicytoma Associated with Acromegaly and Cushing Disease

Cited by 8 publications

References 15 publications

Synchronous Posterior and Anterior Pituitary Tumors: A Case Report of a Hypothetic Paracrine Relationship

Synchronous Posterior and Anterior Pituitary Tumors: A Case Report of a Hypothetic Paracrine Relationship

A rare case of pituicytoma-related hyperprolactinemia due to mass effect on infundibular stalk—Case report

Pituicytoma Associated with Suspected Cushing’s Disease: Two Case Reports and a Literature Review

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