Pitfalls in the Diagnosis of Latex Allergy

Khan, Sujoy; Holding, Stephen; Doré, P.; Sewell, Carrock

doi:10.2332/allergolint.09-oa-0154

Cited by 4 publications

(1 citation statement)

References 11 publications

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“…We could show that IgE latex CAP has a high sensitivity for detection of latex‐sensitized persons, whereas SPT is less sensitive but more specific in our limited patient collective for clinically relevant allergic symptoms. In accordance with other studies IgE latex CAP had high sensitivity but low specificity [4, 21, 22].…”

Section: Discussionsupporting

confidence: 91%

Microarray‐based component‐resolved diagnosis of latex allergy: isolated IgE‐mediated sensitization to latexprofilin Hev b8 may act as confounder

Schuler

Schmid‐Grendelmeier

Harr

2013

Clinical & Translational All

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Immediate type allergy to latex is still a widespread problem. Latex-allergic patients undergoing diagnostic and operative medical procedures are at risk of potentially life-threatening reactions. Accurate diagnostic methods are therefore crucial. The aim of this retrospective study was to discriminate between sensitization and relevant allergy to latex based on an easy and suitable diagnostic approach. In 14 patients with clinical symptoms and 27 controls, latex skin prick tests (SPT), IgE against latex (CAP) and serological component resolved specific latex-allergen determination (Hev b1, b3, b5, b6, b7, b8, b9, b10, b11) based on ImmunoCAP ISAC were performed. SPT correlated very well with clinically manifest latex-allergy demonstrating a high specificity (95%) (and a low sensitivity). However, CAP levels to crude latex could not safely discriminate between purely sensitized and latex-allergic patients. The majority of patients mono-sensitized to the latex profilin Hev b8 did not suffer from any relevant symptoms upon contact with latex. However, in two patients with latex-allergy diagnosed by elevated specific IgE only sensitized against Hev b8, additional sensitization to carbohydrate cross-reactive determinants (CCD) was found. In the case of positive serum IgE against latex and negative SPT, component-resolved diagnosis including IgE against specific latex-proteins, specially Hev b8, and carbohydrate cross-reactive determinants (CCD) is a useful tool to discriminate between latex-sensitization and latex-allergy.

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Section: Discussionsupporting

confidence: 91%

Microarray‐based component‐resolved diagnosis of latex allergy: isolated IgE‐mediated sensitization to latexprofilin Hev b8 may act as confounder

Schuler

Schmid‐Grendelmeier

Harr

2013

Clinical & Translational All

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The Effect of Cytokine-Stimulation and Pharmacologic Intervention on PGE2 Production in Primary Human Conjunctival and Corneal Cells

Shimizu

Yazu

Satake

et al. 2019

Ocular Immunology and Inflammation

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Immunological considerations in the development ofPseudomonas aeruginosavaccines

Baker

McLachlan

Morici

2019

Human Vaccines & Immunotherapeutics

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Pseudomonas aeruginosa is an opportunistic human pathogen capable of causing a wide range of potentially life-threatening infections. With multidrug-resistant P. aeruginosa infections on the rise, the need for a rationally-designed vaccine against this pathogen is critical. A number of vaccine platforms have shown promising results in pre-clinical studies, but no vaccine has successfully advanced to licensure. Growing evidence suggests that an effective P. aeruginosa vaccine may require Th17-type CD4 + T cells to prevent infection. In this review, we summarize recent pre-clinical studies of P. aeruginosa vaccines, specifically focusing on those that induce Th17-type cellular immunity. We also highlight the importance of adjuvant selection and immunization route in vaccine design in order to target vaccine-induced immunity to infected tissues. Advances in cellular immunology and adjuvant biology may ultimately influence better P. aeruginosa vaccine platforms that can protect targeted human populations.

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Pitfalls in the Diagnosis of Latex Allergy

Cited by 4 publications

References 11 publications

Microarray‐based component‐resolved diagnosis of latex allergy: isolated IgE‐mediated sensitization to latexprofilin Hev b8 may act as confounder

Microarray‐based component‐resolved diagnosis of latex allergy: isolated IgE‐mediated sensitization to latexprofilin Hev b8 may act as confounder

The Effect of Cytokine-Stimulation and Pharmacologic Intervention on PGE2 Production in Primary Human Conjunctival and Corneal Cells

Immunological considerations in the development ofPseudomonas aeruginosavaccines

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