piSTING: A Pocket‐Independent Agonist Based on Multivalency‐Driven STING Oligomerization
Shao‐Hua Zhuo,
Tian‐Yang Wang,
Lang Zhao
et al.
Abstract:The stimulator of interferon genes (STING) pathway is a potent therapeutic target for innate immunity. Despite the efforts to develop pocket‐dependent small‐molecule STING agonists that mimic the endogenous STING ligand, cyclic guanosine monophosphate–adenosine monophosphate (cGAMP), most of these agonists showed disappointing results in clinical trials owing to the limitations of the STING pocket. In this study, we developed novel pocket‐independent STING‐activating agonists (piSTINGs), which act through mult… Show more
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