“Pistacia lentiscus L.” reduces the infarct size in normal fed anesthetized rabbits and possess antiatheromatic and hypolipidemic activity in cholesterol fed rabbits

Andreadou, Ioanna; Mitakou, Sofia; Paraschos, S.; Efentakis, Panagiotis; Magiatis, Prokopios; Kaklamanis, Loukas; Halabalaki, Maria; Skaltsounis, Léandros; Iliodromitis, Efstathios K.

doi:10.1016/j.phymed.2016.06.002

Cited by 26 publications

(17 citation statements)

References 28 publications

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“…However, the number of available studies remains relatively small. CMG and CMO have been reported as potent antioxidant [8,9], anti-inflammatory [10,11], cardioprotective [12][13][14], and chemopreventive agents [15][16][17][18][19]. Over the recent years, the increasing number of clinical or intervention trials examining the effect of mastic administration on different disease models further validates the Mediterranean populations' inherent knowledge regarding mastic's therapeutic potential.…”

Section: Introductionmentioning

confidence: 84%

Chemical Profiling of Pistacia lentiscus var. Chia Resin and Essential Oil: Ageing Markers and Antimicrobial Activity

et al. 2021

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Chios Mastic Gum (CMG) and Chios Mastic Oil (CMO) are two unique products of the tree Pistacia lentiscus var. Chia, cultivated exclusively on the Greek island of Chios. In the present study, the method proposed by the European Pharmacopoeia for mastic identification was employed using HPTLC together with an in-house method. A GC-MS methodology was also developed for the chemical characterization of CMOs. α-Pinene and β-myrcene were found in abundance in the fresh oils; however, in the oil of the aged collection, oxygenated monoterpenes and benzenoids such as verbenone, pinocarveol, and α-campholenal were found at the highest rates. Additionally, the antimicrobial activity of Chios Mastic Gums (CMGs) with their respective Chios Mastic Oils (CMOs) was evaluated, with growth tests against the fungi Aspergillus nidulans, Aspergillus fumigatus, Candida albicans, Mucor circinelloides, and Rhizopus oryzae, and the bacteria Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis, with the samples exhibiting a moderate activity. To our knowledge, this is the first time that an HPTLC method is proposed for the analysis of mastic and its essential oil and that a standardized methodology is followed for the distillation of CMO with a parallel assessment of the ageing effect on the oil’s composition.

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Section: Introductionmentioning

confidence: 84%

Chemical Profiling of Pistacia lentiscus var. Chia Resin and Essential Oil: Ageing Markers and Antimicrobial Activity

et al. 2021

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“…In contrast, using a model of 30 min ischaemia and 3 h reperfusion a similar degree of myocardial infarction was observed in cholesterol‐fed and normal fed rabbits (Andreadou et al ., ; ; ; Iliodromitis et al ., ; ). Many other studies have also shown similar infarct sizes in normal and cholesterol‐fed rats with no presence of significant atherosclerosis (Giricz et al ., ; Görbe et al ., ; Csont et al, ; Csonka et al ., ).…”

Section: Effect Of Hypercholesterolaemia On Myocardial Ischaemia/repementioning

confidence: 99%

Effect of hypercholesterolaemia on myocardial function, ischaemia–reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning

Andreadou

Iliodromitis

Lazou

et al. 2017

British J Pharmacology

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“…To identify the extract constituents, chromatographic and spectrometric characteristics were used alongside published specifically retention time, proposed elemental composition (EC), ring double bond equivalent values (RDBeq. ), HRMS/MS spectra and fragmentation patterns ( Lemonakis et al, 2011 ; Andreadou et al, 2016 ; Xynos et al, 2018 ), and natural products databases (PubChem and ChemSpider). The raw data were obtained and processed using XCalibur software version 2.2TM (Thermo Fisher Scientific).…”

Section: Methodsmentioning

confidence: 99%

Chios Mastic Gum Consumption Has a Protective Effect on Ovariectomy-Induced Bone Loss in Rats

Pepe

Lelovas

Pachi

et al. 2021

Prev. Nutr. Food Sci.

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The purpose of this study was to examine the potential effect of Chios Mastic Gum (CMG) consumption on bone mineral density (BMD) and strength of ovariectomized rats. CMG is a known resin used from ancient times for its beneficial biological properties. Thirty mature female Wistar rats were randomized into three equal groups: sham-operated (control), ovariectomized (OVX), and ovariectomized and administered CMG per os (OVX+CMG). BMD of the total tibia, proximal tibia, and the 6th lumbar vertebra were measured at baseline and at 3 and 6 months post ovariectomy. Bone strength was assessed with three-point-bending (3pb) of the right femur. At 3 and 6 months, BMD values of the OVX+ CMG group were significantly higher for the anatomical cites evaluated than those of the OVX group. Femoral thickness assessed via 3pb had intermediate values in the treated group compared to the other groups. Cytology of vaginal smears and uterine weight of the OVX+CMG group were consistent with estrogen depletion. Gastrocnemius muscle and intraperitoneal fat ratios to body weight (BW) of the OVX+CMG group did not significantly differ from the control group. Daily consumption CMG had a protective effect on BMD of the total and proximal tibia and the 6th lumbar vertebra of the rats, without causing undesirable effects on the vaginal epithelium and uterus. The 3pb results also demonstrated a favorable effect on the thickness of rat femurs. In addition, CMG was beneficial for both the muscular system and the intraperitoneal fat/BW ratio of the rats.

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“Pistacia lentiscus L.” reduces the infarct size in normal fed anesthetized rabbits and possess antiatheromatic and hypolipidemic activity in cholesterol fed rabbits

Cited by 26 publications

References 28 publications

Chemical Profiling of Pistacia lentiscus var. Chia Resin and Essential Oil: Ageing Markers and Antimicrobial Activity

Chemical Profiling of Pistacia lentiscus var. Chia Resin and Essential Oil: Ageing Markers and Antimicrobial Activity

Effect of hypercholesterolaemia on myocardial function, ischaemia–reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning

Chios Mastic Gum Consumption Has a Protective Effect on Ovariectomy-Induced Bone Loss in Rats

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