Pironetin, a novel plant growth regulator produced by Streptomyces sp. NK 10958. I. Taxonomy, production, isolation and preliminary characterization.

Kobayashi, Shinichi; Tsuchiya, Kouichi; Harada, Takashi; Nishide, Mituyuki; Kurokawa, Takashi; Nakagawa, Taizo; Shimada, Nobuyoshi; Kobayashi, Kenji

doi:10.7164/antibiotics.47.697

Cited by 96 publications

(29 citation statements)

References 8 publications

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“…Some of these compounds such as lactone monoalcohol (2) [6] and passifloricin A (5) [7] have been found to exhibit antifungal activity. (-)-Pironetin (6) [8] , an immunosuppressive agent, is known to inhibit cell-cycle progression in the M-phase. Kurzilactone (3) [9] and fostriecin (4) [10] are cytotoxic and anticancer agents, respectively.…”

Section: Introductionmentioning

confidence: 99%

Enantio‐ and Diastereocontrolled Total Synthesis of (+)‐Strictifolione

et al. 2010

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Section: Introductionmentioning

confidence: 99%

Enantio‐ and Diastereocontrolled Total Synthesis of (+)‐Strictifolione

et al. 2010

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“…pironetin (165) [299,300] and demethylpironetin (166) [301] produced potent tubulin assembly inhibition by arresting the cell cycle in M phase (G 2 /M) and showing antitumor activity against amurine tumor cell line P338 leukemia, transplanted in mice, with IC 50 value 15 µM. The antitumor activity of these compounds is due to apoptosis caused by the phosphorylation of Bcl-2 and by mitotic arrest [302] .…”

Section: Pironetin and Derivatives (165-167)mentioning

confidence: 98%

Microtubulin Binding Sites as Target for Developing Anticancer Agents

Islam¹,

Iskander²

2004

MRMC

133

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Microtubules (MTs) play important and diverse roles in eukaryotic cells. Their function and biophysical properties have made alpha-and beta-tubulin, the main components of MTs, the subject of intense study. Interfering with normal MT dynamics, for example, by the addition of tubulin ligands, can cause the cell great distress and affect MT stability and functions, including mitosis, cell motion and intracellular organelle transport. It has been shown in the literature that tubulin is an important target molecule for developing anticancer drugs. Tubulin binding molecules have generated considerable interest after the successful introduction of the taxanes into clinical oncology and the widespread use of the vinca alkaloids vincristine and vinblastine. These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization into the MTs. This mode of action is also shared with other natural agents eg colchicine and podophyllotoxin. However various tubulin isotypes have shown resistance to taxanes and other MT agents. Therefore, there is a strong need to design and develop new natural analogs as antimitotic agents to interact with tubulin at sites different from those of vinca alkaloids and taxanes. This minireview provides SAR on several classes of antimitotic agents reported in the literature. The structures and data given are essential to the scientists who are involved in drug design and development in the field of anticancer drugs.

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“…1) was isolated as a plant-growth regulator that induces shortening of the plant height of rice, 61,62) and as an immunosuppressor that inhibits the blastogenesis of both T and B cells. 63) In the course of investigating the molecular mechanisms, we found that pironetin showed antitumor activity against a murine tumor cell line, P388 leukaemia, transplanted in mice, and induced apoptosis via disruption of the cellular microtubule network in situ.…”

Section: Pironetinmentioning

confidence: 99%

Actin- and Microtubule-Targeting Bioprobes: Their Binding Sites and Inhibitory Mechanisms

Usui

2007

Bioscience, Biotechnology, and Biochemistry

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Actin filaments and microtubules play important biological functions in mammalian cells, such as mitosis, cytokinesis, cell signaling, intracellular transport, and cell motility. Therefore, small molecules that interact with these cytoskeletons are expected to be useful not only as antitumor agents, but also as tools for understanding a wide variety of the cellular functions of cytoskeletons. A large number of compounds have been reported as anti-microtubule or anti-actin agents, but only a few compounds have been clarified as to their binding sites on target molecules and their inhibition mechanisms. Here, I describe our recent research into anti-actin and anti-microtubule natural products. Some inhibitors contain active moieties, such as alpha,beta-unsaturated delta-lactone or allely epoxide, in their structure, and covalently bind to their target molecules. Furthermore, some compounds show new inhibition mechanisms by binding on novel sites in target molecules.

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Pironetin, a novel plant growth regulator produced by Streptomyces sp. NK 10958. I. Taxonomy, production, isolation and preliminary characterization.

Cited by 96 publications

References 8 publications

Enantio‐ and Diastereocontrolled Total Synthesis of (+)‐Strictifolione

Enantio‐ and Diastereocontrolled Total Synthesis of (+)‐Strictifolione

Microtubulin Binding Sites as Target for Developing Anticancer Agents

Actin- and Microtubule-Targeting Bioprobes: Their Binding Sites and Inhibitory Mechanisms

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