Pirfenidone Prevents Capsular Contracture After Mammary Implantation

Gancedo, Matias; Ruiz-Corro, Luis; Salazar-Montes, Adriana; Rincón, Ana Rosa; Armendáriz‐Borunda, Juan

doi:10.1007/s00266-007-9051-4

Cited by 60 publications

(40 citation statements)

References 34 publications

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“…This correlates with its potent anti-inflammatory action and the decrease in height and width of the scars shown in this study. 12 Also, PFD has been shown to substantially decrease the expression of various collagens and other profibrogenic genes, 12,18 leading to stopping, controlling, and regression of collagen alterations in pathologic burn scars, and increment in collagen type I, decrease in the collagen type III, and reduction of the extracellular space and an increase in density. 27 Pressure therapy is the treatment most commonly used by occupational therapist and physiotherapist since the mid 19th century and its properties to improve scars, no matter the time of evolution, have been proved across the time by clinical experience, but only few studies have been performed to evaluate its real efficacy.…”

Section: Discussionmentioning

confidence: 99%

A Controlled Clinical Trial With Pirfenidone in the Treatment of Pathological Skin Scarring Caused by Burns in Pediatric Patients

Armendáriz‐Borunda

Lyra-González²,

Medina-Preciado³

et al. 2012

Annals of Plastic Surgery

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Section: Discussionmentioning

confidence: 99%

A Controlled Clinical Trial With Pirfenidone in the Treatment of Pathological Skin Scarring Caused by Burns in Pediatric Patients

Armendáriz‐Borunda

Lyra-González²,

Medina-Preciado³

et al. 2012

Annals of Plastic Surgery

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“…In a study in 2006 [87], the administration of PFD immediately after mammary implantation in a series of 10 rats, and continued for eight weeks reduced inflammation, contracture and capsule thickness when compared to the control. The total content of collagen in the PFD group was 50% less than the control.…”

Section: Medicalmentioning

confidence: 95%

A literature review and summary of capsular contracture: An ongoing challenge to breast surgeons and their patients

Malahias

Jordan

Hughes

et al. 2016

International Journal of Surgery Open

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A B S T R A C TCapsular contracture is a significant difficulty where implants are used in both breast augmentation and breast reconstruction surgery. This report reviews the published literature focusing on factors and techniques that reduce the incidence of this complication, as well as evaluating the available treatment options for patients who have developed a contracture.A search of the MEDLINE database for clinical studies involving the understanding, diagnosis and management of capsular contracture was performed, with 106 articles deemed relevant for this review. Our search criteria included observational studies as we wish to discuss and highlight the areas of this condition that have been investigated, and unfortunately there is limited clinical evidence in regard to high quality trials in this field.Risk factors for capsular contracture are multi-factorial, and all surgeons should aim to minimise these as much as possible both intra-and peri-operatively. However, in high risk patients it is not achievable to completely remove these elements. When capsular contracture does develop, there are currently only a limited number of surgical options including capsulotomy, capsulectomy with or without reimplantation, or reconstruction with autologous tissue. These procedures, as well as the original implant surgery, ought to be discussed with patients on an individual basis, taking into account their personal needs and expectations.The future of this complication may lie in the development of pharmaceutical interventions, and recent studies have shown promising results. Although this field requires more research, the effectiveness of some new pharmaceutical approaches, to provide alternative non-surgical options for patients with capsular contracture, can only aid both patients and the breast surgeon.

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“…[68] observed a reduction in capsule thickness around submmamary tissue, along with a decrease in fibroblast-like cell proliferation, and recruitment and infiltration of inflammatory cells.…”

Section: Organs In Which Pfd Has Been Tested As An Antifibrotic Drugmentioning

confidence: 99%

The multifaceted role of pirfenidone and its novel targets

Macías-Barragán

Sandoval-Rodríguez

Navarro-Partida

et al. 2010

Fibrogenesis Tissue Repair

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131

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Background Pirfenidone (PFD) is a molecule that exhibits antifibrotic properties in a variety of in vitro and animal models of lung, liver and renal fibrosis. These pathologies share many fibrogenic pathways with an abnormal fibrous wound-healing process; consequently, tissue repair and tissue regeneration-regulating mechanisms are altered. Objective To investigate the usefulness of PFD as an antifibrotic agent in clinical and experimental models of fibrotic disease. Conclusions There is a growing understanding of the molecular effects of PFD on the wound healing mechanism, leading to novel approaches for the management of fibrosis in lung, liver and renal tissues. Although the optimum treatment for fibrosis remains undefined, it is possible that combined therapeutic regimens that include this wide-application molecule, pirfenidone, could offer a useful treatment for fibrotic disease.

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Pirfenidone Prevents Capsular Contracture After Mammary Implantation

Cited by 60 publications

References 34 publications

A Controlled Clinical Trial With Pirfenidone in the Treatment of Pathological Skin Scarring Caused by Burns in Pediatric Patients

A Controlled Clinical Trial With Pirfenidone in the Treatment of Pathological Skin Scarring Caused by Burns in Pediatric Patients

A literature review and summary of capsular contracture: An ongoing challenge to breast surgeons and their patients

The multifaceted role of pirfenidone and its novel targets

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