“…model of BLM‐induced lung fibrosis, a single dose of BLM is instilled and results in an inflammatory response that persists for 7–10 days that ultimately leads to lung fibrosis 14–21 days after BLM administration (Carrington et al., ; Degryse & Lawson, ; Jenkins et al., ; Moore et al., ). Although this experimental model was used to show the effectiveness of both nintedanib and pirfenidone (Liu, Lu, Kang, Wang, & Wang, ; Oku et al., ; Wollin et al., ), there are several imperfections in this model that could affect future approaches to IPF drug development (Carrington et al., ; Degryse & Lawson, ; Jenkins et al., ; Moore et al., ). First and most notably, fibrosis completely resolves over time in these mice, which is in contrast to the progressive and non‐resolving nature of fibrosis in IPF.…”