2006
DOI: 10.1038/sj.bjp.0706459
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Piracetam improves mitochondrial dysfunction following oxidative stress

Abstract: 1 Mitochondrial dysfunction including decrease of mitochondrial membrane potential and reduced ATP production represents a common final pathway of many conditions associated with oxidative stress, for example, hypoxia, hypoglycemia, and aging. 2 Since the cognition-improving effects of the standard nootropic piracetam are usually more pronounced under such pathological conditions and young healthy animals usually benefit little by piracetam, the effect of piracetam on mitochondrial dysfunction following oxidat… Show more

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Cited by 83 publications
(66 citation statements)
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References 60 publications
(96 reference statements)
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“…In line with these data are our previous observations of significant mitochondrial protection and enhanced ATP synthesis by piracetam against experimentally induced oxidative as well as nitrosative stress in vitro and after ex vivo treatment, where again aged animals with well-characterized mitochondrial dysfunction benefited most [116]. In agreement with the assumption of mitochondrial membranes as primary target, the beneficial effect of piracetam was similar after experimental impairment of each of the five respiratory chain complexes [116].…”
Section: Ps1-mutations App-mutationssupporting
confidence: 89%
See 1 more Smart Citation
“…In line with these data are our previous observations of significant mitochondrial protection and enhanced ATP synthesis by piracetam against experimentally induced oxidative as well as nitrosative stress in vitro and after ex vivo treatment, where again aged animals with well-characterized mitochondrial dysfunction benefited most [116]. In agreement with the assumption of mitochondrial membranes as primary target, the beneficial effect of piracetam was similar after experimental impairment of each of the five respiratory chain complexes [116].…”
Section: Ps1-mutations App-mutationssupporting
confidence: 89%
“…A drug which has been extensively characterized in this respect is the metabolic enhancer piracetam [115], which shows no antioxidant properties but exhibits pronounced mitochondrial protection ex vivo as well as in vitro [116][117][118] Evidences that piracetam might improve disturbed mitochondrial function originate from observations that piracetam improves glucose uptake and utilization as well as ATP production [119][120][121][122]. In line with these data are our previous observations of significant mitochondrial protection and enhanced ATP synthesis by piracetam against experimentally induced oxidative as well as nitrosative stress in vitro and after ex vivo treatment, where again aged animals with well-characterized mitochondrial dysfunction benefited most [116]. In agreement with the assumption of mitochondrial membranes as primary target, the beneficial effect of piracetam was similar after experimental impairment of each of the five respiratory chain complexes [116].…”
Section: Ps1-mutations App-mutationsmentioning
confidence: 99%
“…In our opinion, different from cells such as human pancreatic cancer MiaPaCa-2 and human prostatic cancer DU-145 cells and proteins like VEGF, in PC12 cells there is a common mechanism for hypoxia and hypoglycemia to regulate the expression of BPRP. Both of hypoxia and hypoglycemia are oxidative stress and lead to mitochondrial dysfunction [40] and then result in HIF-1 signal pathway activation [41]. For example, ROS is accumulated in our study during LOGD [6] and under hypoglycemia [42] in PC12 cells.…”
Section: Discussionmentioning
confidence: 77%
“…In this assay, ATP present in cells drives production of oxyluciferin and light by exogenously added luciferase. This assay reflects cell proliferation and viability, but can also be a measure of mitochondrial function (21,22). Equal numbers of cells from wild-type, G93A, and G37R clones were induced with Dox at different concentrations for 48 h. Luminescence values for mutant clones were expressed as a percent of the wild-type clone.…”
Section: Decreased Association Of Hur and Tiar With Vegf Rna And The mentioning
confidence: 99%