Piperlongumine alleviates lupus nephritis in MRL-Fas(lpr) mice by regulating the frequency of Th17 and regulatory T cells

Yao, Lan; Chen, Haiping; Ma, Qing

doi:10.1016/j.imlet.2014.05.001

Cited by 17 publications

(11 citation statements)

References 24 publications

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“…Similar results were observed in a breast cancer model. The cell apoptosis rate increased following combined treatment of PL with radiation, and the level of intracellular ROS was higher in the combination group than in the group treated with PL or radiation alone (17). These results may be attributed to the decreased expression level of BCL2 and the increased expression level of BCL2 associated X, apoptosis regulator.…”

Section: Discussionmentioning

confidence: 88%

“…PL suppresses the production of tumor necrosis factor-α and interleukin-6, and inhibits the activation of nuclear factor-κB (NF-κB) against proinflammatory responses (16,17). Furthermore, PL prevents plaque formation and inhibits vascular smooth muscle cell migration and invasion via the inhibition of NF-κB activation in atherosclerotic lesions (18).…”

Section: Piperlongumine Inhibits Cancer Stem Cell Properties and Regumentioning

confidence: 99%

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Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer

et al. 2017

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Abstract. Piperlongumine (PL), a natural product ofPiper longum, inhibits multiple malignant phenotypes. Therefore, the present study examined whether PL suppresses cancer stemness in oral cancer. The cellular effects of PL were determined by examining alterations in tumor sphere formation, cell migration, invasion, proliferation ability, chemosensitivity and radiosensitivity. Reverse transcription-quantitative polymerase chain reaction analysis and western blotting were performed in order to determine molecular expression levels. The present study revealed that PL inhibited cancer stem cell-forming ability and suppressed the expression of the stemness-related transcription factors SRY-Box 2, POU class 5 homeobox 1, and Nanog homeobox. However, it increased the expression of the differentiation marker cytokeratin 18. PL also suppressed cell migration and invasion, resulting in the elimination of the epithelial-mesenchymal transition. Furthermore, PL increased chemo-and radiosensitivity and suppressed tumor growth in vitro and in vivo. The results of the present study suggested that PL inhibits malignant phenotypes via the suppression of cancer stemness in oral cancer. Thus, PL may serve as an effective therapeutic agent for oral cancer.

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Section: Discussionmentioning

confidence: 88%

Section: Piperlongumine Inhibits Cancer Stem Cell Properties and Regumentioning

confidence: 99%

Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer

et al. 2017

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“…Peripheral Tregs are significantly increased during remission induction with cyclophosphamide in lupus nephritis . In mice, treatment of lupus nephritis by piperlongumine alleviates lupus nephritis by suppressing the frequency of Th17 cells and increasing the proportion of Tregs . These results suggested that Tregs play an important role in the development of glomerular diseases.…”

Section: Roles Of Tregs In Chronic Kidney Diseases and Glomerular Dismentioning

confidence: 86%

Development and function of Foxp3⁺ regulatory T cells

et al. 2016

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ABSTRACT:Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.

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“…37 The same group showed that in the same model, Foxp3 + RORct + Tregs ('biTregs') were pathogenic, at least in part, because RORct induce the secretion of IL-17 in biTreg cells. 38 A number of treatments in several murine models of lupus have been associated with increased Treg number or function, including, in MRL/lpr strain, IL-33 inhibition, piperlongumine and the 4hydroxyquinoline-3-formamide derivative (known as Y27) [39][40][41] ; in NZBxW/F1 mice, IL-2/IL-2 mAb immune complexes, G-CSF and tuftsin-phosphorylcholine [42][43][44] ; and in the bm12?B6 chronic graftversus-host model of lupus nephritis, microRNA-21 deficiency. 45 Progesterone may also be important for optimal Treg number and function, as progesterone-deficient Nba2 mice have increased antichromatin IgG and proteinuria associated with a decrease in Tregs.…”

Section: Lupus Nephritismentioning

confidence: 99%

Regulatory T cells in renal disease

et al. 2018

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The kidney is vulnerable to injury, both acute and chronic from a variety of immune and metabolic insults, all of which at least to some degree involve inflammation. Regulatory T cells modulate systemic autoimmune and allogenic responses in glomerulonephritis and transplantation. Intrarenal regulatory T cells (Tregs), including those recruited to the kidney, have suppressive effects on both adaptive and innate immune cells, and probably also intrinsic kidney cells. Evidence from autoimmune glomerulonephritis implicates antigen‐specific Tregs in HLA‐mediated dominant protection, while in several human renal diseases Tregs are abnormal in number or phenotype. Experimentally, Tregs can protect the kidney from injury in a variety of renal diseases. Mechanisms of Treg recruitment to the kidney include via the chemokine receptors CCR6 and CXCR3 and potentially, at least in innate injury TLR9. The effects of Tregs may be context dependent, with evidence for roles for immunoregulatory roles both for endogenous Tbet‐expressing Tregs and STAT‐3‐expressing Tregs in experimental glomerulonephritis. Most experimental work and some of the ongoing human trials in renal transplantation have focussed on unfractionated thymically derived Tregs (tTregs). However, induced Tregs (iTregs), type 1 regulatory T (Tr1) cells and in particular antigen‐specific Tregs also have therapeutic potential not only in renal transplantation, but also in other kidney diseases.

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Piperlongumine alleviates lupus nephritis in MRL-Fas(lpr) mice by regulating the frequency of Th17 and regulatory T cells

Cited by 17 publications

References 24 publications

Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer

Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer

Development and function of Foxp3⁺ regulatory T cells

Regulatory T cells in renal disease

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Piperlongumine alleviates lupus nephritis in MRL-Fas(lpr) mice by regulating the frequency of Th17 and regulatory T cells

Cited by 17 publications

References 24 publications

Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer

Piperlongumine inhibits cancer stem cell properties and regulates multiple malignant phenotypes in oral cancer

Development and function of Foxp3+ regulatory T cells

Regulatory T cells in renal disease

Contact Info

Product

Resources

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Development and function of Foxp3⁺ regulatory T cells