Piperine-loaded electrospun nanofibers, an implantable anticancer controlled delivery system for postsurgical breast cancer treatment

Babadi, Delaram; Dadashzadeh, Simin; Shahsavari, Zahra; Shahhosseini, Soraya; Hagen, Timo L.M. ten; Haeri, Azadeh

doi:10.1016/j.ijpharm.2022.121990

Cited by 18 publications

(8 citation statements)

References 60 publications

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“…From the release data, the piperine release flow (µ g/cm 2 /h) was calculated from the extract and the nanoparticles, and there was a statistical difference (p < 0.01) between the samples (Figure 4), indicating that nanoparticles slowed piperine release under used experiment conditions. According to Figure 3, both the standard piperine and the pepper extract had a higher % release at all sampling times compared to NP-PCL-Extract, with values of 28% for the piperine standard, 26% for pepper extract and 16% for NP-PCL-Extract, all in 24 h. The use of the PCL polymer for the nanoencapsulation of the extract can justify the lower % of release, as well as the lower flux of the NP-PCL-Extract (Figure 4); this polymer has been used in other studies with piperine [28,29] and also with other drugs, such as melatonin [42], methotrexate [61], and terbinafine [27], which proved to be promising for a sustained and prolonged release profile of the drug. Babadi et al carried out studies producing nanofibers containing mixtures of PCL and collagen for the release of piperine for postsurgical breast cancer treatment.…”

Section: Piperine In Vitro Releasementioning

confidence: 98%

“…Poly-ε-caprolactone (PCL) is a semi-crystalline aliphatic polyester of great interest, since it is a hydrophobic polymer with a lower cost than other aliphatic polyesters [24,25]. Due to its slow degradation and absence of toxicity, PCL has been investigated for use in drug and vaccine delivery systems [26,27] and has already been studied for piperine delivery as an electrospun nanofiber for cancer therapy [28,29]. PCL nanoparticles have been used for topical applications, with studies showing that they can prolong the residence time of actives in upper layers of skin, and even increase the rate and extent of transport across the skin [23,27,[30][31][32].…”

Section: Introductionmentioning

confidence: 99%

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Piperine Extraction and Encapsulation in Polycaprolactone Nanoparticles

Coco,

Silvério,

Santos

et al. 2023

Cosmetics

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Black pepper, a commonly utilized culinary condiment, holds significant importance in Ayurvedic and Chinese medicinal practices due to its various biological benefits, including antioxidant, antimicrobial, and anti-inflammatory properties. To amplify these attributes and enhance their efficacy in formulations, the utilization of nanocarriers presents a promising approach. Thus, the objective of this study was to obtain a pepper extract, evaluate its constituents, and encapsulate it in polymeric nanoparticles. The ethanol extract of the grains powder had a higher concentration of piperine and better antioxidant activity when compared to whole grains. Pepper extract encapsulation efficiency in terms of piperine concentration was 84.8 ± 3.5%, and a sustained and prolonged release profile was observed, as well as other studies in the literature using polycaprolactone (PCL). The presence of the extract did not change the instability index and the sedimentation velocity of the nanoparticles, as well as the polydispersity index and the zeta potential of nanoparticles. However, there was a difference in the mean size and concentration of particles. This study highlights the potential of PCL nanoparticles as a promising delivery system for black pepper extract, which could have various applications in the cosmetic and pharmaceutical industries, maximizing the benefits of black pepper extract.

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Section: Piperine In Vitro Releasementioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Piperine Extraction and Encapsulation in Polycaprolactone Nanoparticles

Coco,

Silvério,

Santos

et al. 2023

Cosmetics

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“…These results point to the possibility of tailored cancer therapy using NF-based drug delivery systems. 67 In addition, there have been encouraging outcomes with nanoparticles loaded with chemicals such as Chr and Cur. These nanoparticles demonstrated sustained and regulated release characteristics, working in concert to cause apoptosis in BC cells.…”

Section: Plant Extract–loaded Scaffolds In Bc Treatmentmentioning

confidence: 99%

“… 39 In a test on mice, all mice survived the procedure and both methods and treatments were well received as the mice showed minimal weight changes. 67 …”

Section: Plant Extract–loaded Scaffolds In Bc Treatmentmentioning

confidence: 99%

Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

Azhari Rad,

Naghdi,

Majidi Jamalabadi

et al. 2024

Breast Cancer�(Auckl)

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Despite recent improvements in detecting and managing breast cancer (BC), it continues to be a major worldwide health concern that annually affects millions of people. Exploring the anti-BC potentials of natural compounds has received a lot of scientific attention due to their multi-target mode of action and good safety profiles because of these unmet needs. Drugs made from herbs are secure and have a lot fewer negative effects than those made from synthetic materials. Early stage patients benefit from breast-conserving surgery, but the risk of local recurrence remains, necessitating implanted scaffolds. These scaffolds provide residual cancer cell killing and tailored drug delivery. This review looks at plant extract–infused tissue engineering scaffolds, which provide a novel approach to treating BC. By offering patient individualized, safer treatments, these scaffolds could completely change how BC is treated.

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“… Examples of electrospun membranes fabricated with varied implantable polymeric materials (PLA [ 93 ], PGA, PLGA [ 94 ], PCL [ 95 ], chitosan [ 94 ]), loaded drugs (DOX, 5-FU [ 96 ], paclitaxel (PTX), and cisplatin (CIS) [ 71 ]), techniques (blend electrospinning, emulsion electrospinning [ 97 ], coaxial electrospinning [ 98 ], and surface modification [ 99 ]), and therapeutic applications (electrospun piperine loaded PCL against breast tumor [ 100 ], electrospun oxaliplatin loaded PLLA preventing local cervical carcinoma recurrence [ 101 ], and electrospun temozolomide loaded PLGA-PLA-PCL for localized treatment of recurrent glioma [ 102 ]). Images are reprinted with copyright permissions or under the Creative Commons CC-BY license.…”

Section: Figurementioning

confidence: 99%

A Review of the Release Profiles and Efficacies of Chemotherapy Drug-Loaded Electrospun Membranes

Lin

Chen

et al. 2023

Polymers

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Electrospun fibrous membranes loaded with chemotherapy drugs have been broadly studied, many of which have had promising data demonstrating therapeutic effects on cancer cell inhibition, tumor size reduction, the life extension of tumor-bearing animals, and more. Nevertheless, their drug release profiles are difficult to predict since their degradation pattern varies with crystalline polymers. In addition, there is room for improving their release performances, optimizing the release patterns, and achieving better therapeutic outcomes. In this review, the key factors affecting electrospun membrane drug release profiles have been systematically reviewed. Case studies of the release profiles of typical chemotherapy drugs are carried out to determine the preferred polymer choices and techniques to achieve the expected prolonged or enhanced release profiles. The therapeutic effects of these electrospun, chemo-drug-loaded membranes are also discussed. This review aims to assist in the design of future drug-loaded electrospun materials to achieve preferred release profiles with enhanced therapeutic efficacies.

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Piperine-loaded electrospun nanofibers, an implantable anticancer controlled delivery system for postsurgical breast cancer treatment

Cited by 18 publications

References 60 publications

Piperine Extraction and Encapsulation in Polycaprolactone Nanoparticles

Piperine Extraction and Encapsulation in Polycaprolactone Nanoparticles

Tissue Engineering Scaffolds Loaded With a Variety of Plant Extracts: Novel Model in Breast Cancer Therapy

A Review of the Release Profiles and Efficacies of Chemotherapy Drug-Loaded Electrospun Membranes

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