Piperine-loaded chitosan-STPP nanoparticles reduce neuronal loss and astrocytes activation in chemical kindling model of epilepsy

Anissian, Diana; Ghasemi-Kasman, Maryam; Khalili-Fomeshi, Mohsen; Akbari, Atefeh; Hashemian, Mona; Kazemi, Sohrab; Moghadamnia, Ali Akbar

doi:10.1016/j.ijbiomac.2017.09.073

Cited by 78 publications

(48 citation statements)

References 34 publications

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“…In addition, chitosan treatment suppresses oxidative stress-induced Aβ formation in NT2 neurons [ 307 ]. Piperine loaded on chitosan-sodium tripolyphosphate nanoparticles (CS-STPP NPs) reduced neuronal loss and astrocyte activation in a chemical kindling model of epilepsy [ 308 ].…”

Section: Prevention and Treatment Of Nddsmentioning

confidence: 99%

Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions

Penke

Bogár

Crul

et al. 2018

IJMS

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Neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease (HD), amyotrophic lateral sclerosis, and prion diseases are all characterized by the accumulation of protein aggregates (amyloids) into inclusions and/or plaques. The ubiquitous presence of amyloids in NDDs suggests the involvement of disturbed protein homeostasis (proteostasis) in the underlying pathomechanisms. This review summarizes specific mechanisms that maintain proteostasis, including molecular chaperons, the ubiquitin-proteasome system (UPS), endoplasmic reticulum associated degradation (ERAD), and different autophagic pathways (chaperon mediated-, micro-, and macro-autophagy). The role of heat shock proteins (Hsps) in cellular quality control and degradation of pathogenic proteins is reviewed. Finally, putative therapeutic strategies for efficient removal of cytotoxic proteins from neurons and design of new therapeutic targets against the progression of NDDs are discussed.

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Section: Prevention and Treatment Of Nddsmentioning

confidence: 99%

Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions

Penke

Bogár

Crul

et al. 2018

IJMS

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“…Advances in nanotechnology led to the development of different nanoparticle formulations that recently used as therapeutic agents against various health problems. 12 , 13 The effect of nanoparticles on tissues depends on their characteristics including size, shape, dose, concentration and type of nanoparticle, type of tissue, and period of exposure. 14 Due to their nanoform proportions and other useful surface reactivity, nanoparticles are widely employed in various biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

<p>Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice</p>

Yuan¹,

Fu²,

Ji³

et al. 2020

IJN

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Introduction: Epilepsy is a chronic neurological condition characterized by behavioral, molecular, and neurochemical alterations. Current antiepileptic drugs are associated with various adverse impacts. The main goal of the current study is to investigate the possible anticonvulsant effect of selenium nanoparticles (SeNPs) against pentylenetetrazole (PTZ)mediated epileptic seizures in mice hippocampus. Sodium valproate (VPA) was used as a standard anti-epileptic drug. Methods: Mice were assigned into five groups (n=15): control, SeNPs (5 mg/kg, orally), PTZ (60 mg/kg, intraperitoneally), SeNPs+PTZ and VPA (200 mg/kg)+PTZ. All groups were treated for 10 days. Results: PTZ injection triggered a state of oxidative stress in the hippocampal tissue as represented by the elevated lipoperoxidation, heat shock protein 70 level, and nitric oxide formation while decreased glutathione level and antioxidant enzymes activity. Additionally, the blotting analysis showed downregulation of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) in the epileptic mice. A state of neuroinflammation was recorded following the developed seizures represented by the increased pro-inflammatory cytokines. Moreover, neuronal apoptosis was recorded following the development of epileptic convulsions. At the neurochemical level, acetylcholinesterase activity and monoamines content were decreased in the epileptic mice, accompanied by high glutamate and low GABA levels in the hippocampal tissue. However, SeNP supplementation was found to delay the onset and decreased the duration of tonic, myoclonic, and generalized seizures following PTZ injection. Moreover, SeNPs were found to provide neuroprotection through preventing the development of oxidative challenge via the upregulation of Nrf2 and HO-1, inhibiting the inflammatory response and apoptotic cascade. Additionally, SeNPs reversed the changes in the activity and levels of neuromodulators following the development of epileptic seizures. Conclusion: The obtained results suggest that SeNPs could be used as a promising anticonvulsant drug due to its potent antioxidant, anti-inflammatory, and neuromodulatory activities.

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“…To improve the embedding rate of piperine, the polysaccharide could be used as matrix. As the only cation polysaccharide in nature, chitosan was able to enhance the embedding rate of piperine to 53% [32] while the piperine nanoparticles prepared by chitosan. Cyclodextrin is a kind of special oligosaccharide with annular cavity structure.…”

Section: Piperine Nanoparticles Based On Polysaccharide Matrixmentioning

confidence: 98%

Advance on delivery nanocarriers of piperine: nanoparticles

Lingli¹

2019

E3S Web Conf.

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Piperine is a kind of natural functional active components with spicy flavor and varies pharmacology effects. It has wide application in the food and medicine industries. However, the solubility of piperine is low, and it was easy to be transformed or degraded during the conditions of acid, alkali, light, heat and oxygen which lead to the vanish of its function. In order to enhance the stability of piperine, the nanotechnology was utilized to fabricate the delivery carrier of piperine. In this paper, the latest research progress of piperine nanoparticles was reviewed by summarizing domestic and foreign literature. The characteristics, preparation methods, preparation materials and stability of nanoparticle delivery carriers were systematically discussed. Finally, the present problems and future development of piperine delivery carrier were analyzed and forecasted in order to provide a reference for profound process and study of piperine.

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Piperine-loaded chitosan-STPP nanoparticles reduce neuronal loss and astrocytes activation in chemical kindling model of epilepsy

Cited by 78 publications

References 34 publications

Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions

Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions

<p>Selenium Nanoparticles Pre-Treatment Reverse Behavioral, Oxidative Damage, Neuronal Loss and Neurochemical Alterations in Pentylenetetrazole-Induced Epileptic Seizures in Mice</p>

Advance on delivery nanocarriers of piperine: nanoparticles

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