Piperine: An Anticancer and Senostatic Drug

Lim, Jae Sung; Lee, Da Young; Lim, Ju Hyeon; Oh, Won Keun; Park, Jun; Park, Sang Chul; Cho, Kyung A

doi:10.31083/j.fbl2704137

Cited by 10 publications

(7 citation statements)

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“…Furthermore, this lineage is the only selective, regarding the non-tumor model (VERO), with a selectivity index (SI) [ 64 , 65 ] of 3.6, demonstrating that P2 has specific mechanisms in the tumor cells. The selective action of piperine has been reported for other cancer models, with higher cytotoxicity against tumor cells compared to normal ones [ 33 , 66 ]. These results show that piperine is safe for therapeutic use, being even advantageous over other non-selective tested molecules and substances of clinical use [ 67 , 68 ].…”

Section: Resultsmentioning

confidence: 99%

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

et al. 2023

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Gastric cancer is one of the most frequent types of neoplasms worldwide, usually presenting as aggressive and difficult-to-manage tumors. The search for new structures with anticancer potential encompasses a vast research field in which natural products arise as promising alternatives. In this scenario, piperine, an alkaloid of the Piper species, has received attention due to its biological activity, including anticancer attributes. The present work proposes three heating-independent, reliable, low-cost, and selective methods for obtaining piperine from Piper nigrum L. (Black pepper). Electronic (SEM) and optical microscopies, X-ray diffraction, nuclear magnetic resonance spectroscopies (13C and 1H NMR), and optical spectroscopies (UV–Vis, photoluminescence, and FTIR) confirm the obtention of piperine crystals. The MTT assay reveals that the piperine samples exhibit good cytotoxic activity against primary and metastasis models of gastric cancer cell lines from the Brazilian Amazon. The samples showed selective cytotoxicity on the evaluated models, revealing higher effectiveness in cells bearing a higher degree of aggressiveness. Moreover, the investigated piperine crystals demonstrated the ability to act as a good cytotoxicity enhancer when combined with traditional chemotherapeutics (5-FU and GEM), allowing the drugs to achieve the same cytotoxic effect in cells employing lower concentrations. These results establish piperine as a promising molecule for therapy investigations in aggressive gastric cancer, both in its isolated form or as a bioenhancer.

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Section: Resultsmentioning

confidence: 99%

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

et al. 2023

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“…Given the pivotal function of TGF-β in senescence re-enforcement and cancer immune evasion, it was selected as another SASP factor in this study [ 34 , 37 ]. Piperine, a natural bioactive component, modulated the secretion of SASP factors: IL-6, IL-8, and TGF-β1 [ 38 ]. Metformin alleviated the angiotensin II-induced SASP by down-regulating MMP-2, IL-6, and TGF-β [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer

ZHOU,

WAN,

XIAO

et al. 2024

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Breast and lung cancers are the leading causes of mortality and most frequently diagnosed cancers in women and men, respectively, worldwide. Although the antitumor activity of chalcones has been extensively studied, the molecular mechanisms of isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood. In this study, we found that TEC inhibited cell proliferation of breast cancer BT549 cells and lung cancer A549 cells in a concentration-dependent manner. TEC induced cell cycle arrest in the S-phase, cell migration inhibition in vitro , and reduced tumor growth in vivo . Moreover, transcriptomic analysis revealed that TEC modulated the activity of the JAK2/STAT3 and P53 pathways. TEC triggered the senescence-associated secretory phenotype (SASP) by repressing the JAK2/STAT3 axis. The mechanism of metochalcone against breast cancer depended on the induction of SASP via deactivation of the JAK2/STAT3 pathway, highlighting the potential of chalcone in senescence-inducing therapy against carcinomas.

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Section: Introductionmentioning

confidence: 99%

“…In 2022, Lim et al showed that piperine can simultaneously induce senostatic effects and the removal of cancer cells . When added at 70 μM, ROS production, SASP secretome, and SA-β-gal activity were all reduced, while cell division, marked by ERK1/2 phosphorylation, was recovered, ultimately leading to differentiation, migration, and survival . Furthermore, piperine has been shown to be neuroprotective in several models of brain aging and AD models. ,,− ,− Piperine was shown to promote reduction of lipid peroxidation, inhibition of acetylcholinesterase (AchE) and restoration of monoamine neurotransmission as well as neurotrophic effect in hippocampus, slowing down cognitive impairments in brain aging and AD context …”

Section: Introductionmentioning

confidence: 99%

Amide Alkaloids as Privileged Sources of Senomodulators for Therapeutic Purposes in Age-Related Diseases

Dotou,

L’honoré,

Moumné

et al. 2024

J. Nat. Prod.

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Nature is an important source of bioactive compounds and has continuously made a large contribution to the discovery of new drug leads. Particularly, plant-derived compounds have long been identified as highly interesting in the field of aging research and senescence. Many plants contain bioactive compounds that have the potential to influence cellular processes and provide health benefits. Among them, Piper alkaloids have emerged as interesting candidates in the context of age-related diseases and particularly senescence. These compounds have been shown to display a variety of features, including antioxidant, anti-inflammatory, neuroprotective, and other bioactive properties that may help counteracting the effects of cellular aging processes. In the review, we will put the emphasis on piperlongumine and other related derivatives, which belong to the Piper alkaloids, and whose senomodulating potential has emerged during the last several years. We will also provide a survey on their potential in therapeutic perspectives of age-related diseases.

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Piperine: An Anticancer and Senostatic Drug

Cited by 10 publications

References 0 publications

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

Extraction, Characterization, and Evaluation of the Cytotoxic Activity of Piperine in Its Isolated form and in Combination with Chemotherapeutics against Gastric Cancer

Metochalcone induces senescence-associated secretory phenotype via JAK2/STAT3 pathway in breast cancer

Amide Alkaloids as Privileged Sources of Senomodulators for Therapeutic Purposes in Age-Related Diseases

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