Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination

Roshanbakhsh, Hannaneh; Salmani, Mahmoud Elahdadi; Dehghan, Samaneh; Nazari, Atena; Javan, Mohammad; Pourabdolhossein, Fereshteh

doi:10.1016/j.lfs.2020.117671

Cited by 25 publications

(24 citation statements)

References 88 publications

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“…A more recent study showed that Piperine treatment enhances memory performance and improves myelin repair in LPC induced demyelination rat model. (Roshanbakhsh et al, 2020). The present study substantiates the claim that piperine can binds to the molecular targets as mentioned in the previous studies mentioned above and can have effect of CNS related neuroprotective effects.…”

Section: Discussionsupporting

confidence: 91%

Downregulation of Candidate Gene Expression and Neuroprotection by Piperine in Streptozotocin-Induced Hyperglycemia and Memory Impairment in Rats

et al. 2021

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There is accumulating evidence showing that hyperglycemia conditions like diabetes possess a greater risk of impairment to the neuronal system because high glucose levels exacerbate oxidative stress, accumulation of amyloid-beta peptides, and mitochondrial dysfunction, and impair cognitive functions and cause neurodegeneration conditions like Alzheimer’s diseases. Due to the extensive focus on pharmacological intervention to prevent neuronal cells’ impairment induced by hyperglycemia, the underlying molecular mechanism that links between Diabetes and Alzheimer’s is still lacking. Given this, the present study aimed to evaluate the protective effect of piperine on streptozotocin (STZ) induced hyperglycemia and candidate gene expression. In the present study, rats were divided into four groups: control (Vehicle only), diabetic control (STZ only), piperine treated (20 mg/kg day, i.p), and sitagliptin (Positive control) treated. The memory function was assessed by Morris water maze and probe test. After treatment, biochemical parameters such as HOMA index and lipid profile were estimated in the serum, whereas histopathology was evaluated in pancreatic and brain tissue samples. Gene expression studies were done by real-time PCR technique. Present data indicated that piperine caused significant memory improvement as compared to diabetic (STZ) control. The assessment of HOMA indices in serum samples showed that piperine and sitagliptin (positive control, PC) caused significant alterations of insulin resistance, β cell function, and insulin sensitivity. Assessment of brain and pancreas histopathology shows significant improvement in tissue architecture in piperine and sitagliptin treated groups compared to diabetic control. The gene expression profile in brain tissue shows significantly reduced BACE1, PSEN1, APAF1, CASPASE3, and CATALASE genes in the piperine and sitagliptin (PC) treated groups compared to Diabetic (STZ) control. The present study demonstrated that piperine not only improves memory in diabetic rats but also reduces the expression of specific AD-related genes that can help design a novel strategy for therapeutic intervention at the molecular level.

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Section: Discussionsupporting

confidence: 91%

Downregulation of Candidate Gene Expression and Neuroprotection by Piperine in Streptozotocin-Induced Hyperglycemia and Memory Impairment in Rats

et al. 2021

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“…Our data also demonstrated that treatment with cumin and black pepper extract has potent memory-enhancing effects on animal behavioral tests. Piperine is one of the most effective ingredients in black pepper fruit, which have revealed considerable improvements in memory loss in previous animal model studies [ 36 , 37 ]. The possible mechanism of this effect has suggested the improvement of neural density and cholinergic function in the hippocampus [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Besides oxidative stress, inflammatory processes play an important role in the pathogenesis of cognitive impairment associated with neurodegenerative diseases [ 48 ]. Roshanbakhsh et al indicated that piperine enhanced antioxidant capacity, inhibited iNOS, and reduced TNF- α , IL1- β , and NF- κ B expression levels, in the hippocampal tissue [ 37 ]. Owing to the anti-inflammatory activity of piperine, anti-inflammatory mechanisms may also be involved in the observed black pepper activity, although further investigation is necessary to characterize the active constituent(s) of cumin and black pepper responsible for such activities.…”

Section: Discussionmentioning

confidence: 99%

The Effect of a Traditional Preparation Containing Piper nigrum L. and Bunium persicum (Boiss.) B.Fedtsch. on Immobility Stress-Induced Memory Loss in Mice

Rashedinia

Mojarad

Khodaei

et al. 2021

BioMed Research International

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Objective. Alzheimer’s disease is a progressive, age-related, and neurodegenerative disease characterized by mental decline. The exact cause of Alzheimer’s disease is unclear, but cholinergic dysfunction, protein accumulation, and oxidative stress are among the most important hypotheses. The main purpose of our study was to investigate the effects of aqueous and hydroalcoholic extract combination of these two medicinal plants, black pepper and cumin (as a related formulation in traditional Persian medicine), on memory and learning of an immobilized stress animal model. Methods. In this study, hydroalcoholic and aqueous extracts of cumin and black pepper fruits were prepared. Six groups of mice were treated orally for 2 weeks: control group, immobility stress, and stress-induced immobility mice received different doses of the hydroalcoholic extract (100 and 200 mg/kg) and aqueous extract (100 and 200 mg/kg). The shuttle box, novel object detection, and rotarod test were used to evaluate memory and learning. The activities of acetylcholinesterase, catalase (CAT), and superoxide dismutase (SOD) and the level of reduced glutathione (GSH) and malondialdehyde (MDA) were measured in the brain tissue. Results. Immobility stress significantly reduced learning and motor coordination. Furthermore, MDA levels and acetylcholinesterase activity were significantly increased, while CAT and SOD activities were significantly reduced in the brain of immobility-induced stress mice. Other findings indicated that hydroalcoholic and aqueous extracts (100 and 200 mg/kg) of cumin and black pepper fruits have an improving effect on animal motor coordination and learning ability, GSH content, and CAT, SOD, and acetylcholinesterase enzyme function in comparison with stress groups ( p < 0.05 ). Conclusion. The hydroalcoholic and aqueous extracts of cumin and black pepper fruits have protective effects against stress-induced memory deficit and oxidative stress and may have beneficial therapeutic effect in the treatment of neurodegenerative diseases.

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“…This antioxidant effect was associated with AChE inhibition and the procognitive effect in the novel object recognition test and Y-Maze test ( Nazir et al, 2020 ). The study of Roshanbakhsh et al (2020) revealed that another natural compound, piperine, improved memory impairments in rats by diminishing the iNOS level and increasing TAC in the hippocampus. This effect was associated with spatial memory improvement in the Morris water maze test ( Roshanbakhsh et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…The study of Roshanbakhsh et al (2020) revealed that another natural compound, piperine, improved memory impairments in rats by diminishing the iNOS level and increasing TAC in the hippocampus. This effect was associated with spatial memory improvement in the Morris water maze test ( Roshanbakhsh et al, 2020 ). The scopolamine model of dementia was used by Ngoupaye et al (2017) to prove the antioxidative effect of Gladiolus dalenii lyophilisate in the process of working and spatial memory improvement.…”

Section: Discussionmentioning

confidence: 99%

Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms

et al. 2020

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Bergapten is a furanocoumarin naturally occurring in the Apiaceae family and it is a well-known photosensitizing agent used in photochemotherapy. In this study, we investigated the influence of bergapten on cognitive function and mechanism underlying these effects in scopolamine-induced memory impairment in male Swiss mice. The passive avoidance test was used to evaluate the efficiency of memory acquisition and consolidation. The results demonstrated that both single and repeated administration of bergapten improved not only the acquisition but also consolidation of memory. The behavioral tests showed that bergapten prevented memory impairment induced by administration of scopolamine. Observed effects may result from the inhibition of acetylcholinesterase activity in the hippocampus and prefrontal cortex. Also, bergapten caused significant anti-oxidative effects. These new findings provide pharmacological and biochemical support for the development of the coumarin’s potential in cognitive deficits.

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Piperine ameliorated memory impairment and myelin damage in lysolecethin induced hippocampal demyelination

Cited by 25 publications

References 88 publications

Downregulation of Candidate Gene Expression and Neuroprotection by Piperine in Streptozotocin-Induced Hyperglycemia and Memory Impairment in Rats

Downregulation of Candidate Gene Expression and Neuroprotection by Piperine in Streptozotocin-Induced Hyperglycemia and Memory Impairment in Rats

The Effect of a Traditional Preparation Containing Piper nigrum L. and Bunium persicum (Boiss.) B.Fedtsch. on Immobility Stress-Induced Memory Loss in Mice

Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms

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