The availability of drugs with psychotropic effects on worldwide market constitutes a significant threat to public health and a problem for drug policy. Frequently, little is known about the detrimental effects on health and the social implications, making prevention and therapy difficult. It is difficult to analyze and identify a significant number of chemically varied drugs prevalent in pharmaceuticals marketplaces at the same manner. To respond to this circumstance, it is necessary to monitor, share information, provide early warning, and be aware of risks. NPS has been referred to in the market as "bath salts," "legal highs," and "research chemicals." According to the United Nations Office on Drugs and Crime," abusive substance, whether in its original form or a mixture, that is not controlled by the 1961 International Convention on Illicit Drugs or the 1971 Convention on the Control of Psychotropic Drugs but which may pose a global health threat is referred to as a "new psychoactive substance" NPS. Numerous NPS were initially synthesized decades ago, therefore the descriptor "new" does not always indicate to new items .instead, it refers to compounds that have recently become accessible to consumers.