Piperacillin-Tazobactam vs Cefoxitin Prophylaxis for Pancreatoduodenectomy—Reply

Abstract

Hopkins entered into a contract with the US Department of Housing and Urban Development (HUD) for him to work part-time on a temporary assignment assisting the agency on housing and health issues. Dr Keet reported receiving personal fees from the American Board of Allergy and Immunology, the Journal of Allergy and Clinical Immunology, and UpToDate. No other disclosures were reported. Disclaimer:The findings and conclusions in this report are those of the authors and do not necessarily represent those of HUD.

Antimicrobial Prophylaxis with Ampicillin-sulbactam Compared with Cefazolin for Esophagectomy

“…Antimicrobial prophylaxis is strongly recommended for preventing SSI in clean-contaminated procedures such as gastrointestinal surgery. 6,7 Moreover, recent studies suggest that the administration of the optimal procedure-specific antimicrobial agents can reduce procedure-specific complications (eg, anastomotic leakage after colorectal surgery, 8,9 pancreatic fistula after pancreatoduodenectomy, 10 and pneumonia after lung surgery 11 ) as well as SSI. Although the incidence of SSI, anastomotic leakage, and respiratory complications is the highest with esophagectomy among gastrointestinal surgeries, 7,12,13 there is a dearth of randomized controlled trials and large-scale retrospective studies comparing antimicrobial prophylaxis in esophagectomy; thus, the optimal antimicrobial regimen remains unknown.…”