Piper sylvaticum Roxb.

Khare, C.P.

doi:10.1007/978-0-387-70638-2_1209

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“…The plant has several parts, such as leaves, the stem, roots, fruits, and seeds, and most of them have wide traditional uses for the treatment of various diseases such as rheumatic pain, headaches, chronic cough, cold, asthma, piles, diarrhea, wounds in lungs, tuberculosis, indigestion, dyspepsia, hepatomegaly, and pleenomegaly [7][8][9]. Besides, the root of this plant is used as carminative, and the aerial parts have diuretic actions [10]. The preliminary qualitative phytochemical analysis of this plant (leaves and stem) revealed the presence of several phytochemicals, including alkaloids, flavonoids, carbohydrates, tannins, and saponins.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Piper sylvaticum Roxb. Leaves and Stems for Anxiolytic and Antioxidant Properties Through In Vivo, In Vitro, and In Silico Approaches

et al. 2020

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Piper sylvaticum Roxb. is traditionally used by the indigenous people of tropical and subtropical countries like Bangladesh, India, and China for relieving the common cold or a variety of chronic diseases, such as asthma, chronic coughing, piles, rheumatic pain, headaches, wounds, tuberculosis, indigestion, and dyspepsia. This study tested anxiolytic and antioxidant activities by in vivo, in vitro, and in silico experiments for the metabolites extracted (methanol) from the leaves and stems of P. sylvaticum (MEPSL and MEPSS). During the anxiolytic evaluation analyzed by elevated plus maze and hole board tests, MEPSL and MEPSS (200 and 400 mg/kg, body weight) exhibited a significant and dose-dependent reduction of anxiety-like behavior in mice. Similarly, mice treated with MEPSL and MEPSS demonstrated dose-dependent increases in locomotion and CNS simulative effects in open field test. In addition, both extracts (MEPSL and MEPSS) also showed moderate antioxidant activities in DPPH scavenging and ferric reducing power assays compared to the standard, ascorbic acid. In parallel, previously isolated bioactive compounds from this plant were documented and subjected to a molecular docking study to correlate them with the pharmacological outcomes. The selected four major phytocompounds displayed favorable binding affinities to potassium channel and xanthine oxidoreductase enzyme targets in molecular docking experiments. Overall, P. sylvaticum is bioactive, as is evident through experimental and computational analysis. Further experiments are necessary to evaluate purified novel compounds for the clinical evaluation.

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Section: Introductionmentioning

confidence: 99%