Piper sarmentosum as an Antioxidant: A Systematic Review

Abstract

Piper sarmentosum (PS) is an herb with various medicinal properties. The antioxidant activity of PS contributes to many of its pharmacological effects such as anti-hypertension, anti-cancer and anti-diabetes. This systematic review provides information regarding the antioxidant activity of PS. The review was conducted systematically to identify relevant published articles on the antioxidant activity of PS. The collected data was based on the searched articles through PubMed, Science Direct and Scopus databases between the years 1946 until March 2018. Only articles written in English and related to antioxidant activity of PS were included in this review. Based on the literature searched, 130 potential articles were identified and 19 articles met the inclusion criteria. Ten studies related to chemical assays, five studies combined in vivo animal and chemical assays, three studies combined chemical assays and in vitro studies and a single study combined chemical assay, in vitro and in vivo studies were included in this review. All studies showed positive effects of PS against oxidation, indicating the potential of PS as a source of natural antioxidant.

The effects of Piper sarmentosum aqueous extracts on zebrafish (Danio rerio) embryos and caudal fin tissue regeneration

“…The most abundant compound, hydrocinnamic acid, is a derivative of cinnamic acid, a compound that exhibits strong antioxidant activity due to the presence of a CH=CH–COOH (prop-2-enoic acid) moiety 35 – 38 . Antioxidant activities of P. sarmentosum extracts identified through DPPH assays have also been reported in other studies 39 , 40 . The DPPH radical model was also applied in our study to evaluate the free radical scavenging activity of P. sarmentosum aqueous extract.…”

The Role of Piper sarmentosum Aqueous Extract as a Bone Protective Agent, a Histomorphometric Study

“…In Malaysia and Indonesia, this plant is used in traditional medicine for treating toothache, pleuritis, asthma, diabetes, hypertension, joint pain and fungal infections. Phytochemicals of Ps indicate that the methanol extracts of this plant contain naringenin, a flavonoid [ 23 , 29 , 54 ]. Flavonoids are known to reduce bone loss and increase bone strength in ovariectomised rats [ 55 ].…”

“…It is known locally in Malaysia as ‘daun kaduk’. Phytochemical studies of Piper species led to the separation of several clusters of active components, such as amides, propenylphenols, lignans, steroids, flavonoids, ketones, carboxylic acids, phytosterols and phenyls [ 21 , 22 , 23 ]. Many studies have shown that Piper sarmentosum possesses pharmacological effects such as anti-tuberculosis [ 19 , 24 ], anti-cancer [ 25 ], hypoglycaemic action [ 26 , 27 ], anti-malarial [ 28 ], antioxidant [ 29 ], neuromuscular blocking action [ 30 ], anti-atherosclerosis [ 31 ] and anti-inflammation [ 32 ] activities.…”

Evaluation of mangosteen (Garcinia mangostana) antioxidant activity in clinical trials and in vivo animal studies: A systematic review

“…A significant increase in SOD levels showed that mangosteen extract or products promote the activity of SOD enzyme in neutralizing oxidative stress. A significant decrease in the SOD level could be due to the direct activity of mangosteen extract or products in neutralizing ROS which reduces the need for an antioxidant enzyme such as SOD (Ismail et al, 2018). All studies with evaluated CAT (n = 13) and GPx (n = 10) levels showed a significant increase in both enzyme levels after the subjects were treated with mangosteen extract or product.…”