In this work, the effect of nanoparticles in deasphalting heavy oil and extra-heavy oil process at laboratory-scale based on the conventional solvent deasphalting process was studied and named enhanced-solvent deasphalting (e-SDA) process. This work evaluated the effect of the nanoparticles of SiO2in the separation efficiency based on deasphalted oil (DAO) fraction quality compared to the conventional process of deasphalting (SDA). Different effects have been assessed such as solvent to oil ratio, operating temperatures, type of solvent, and SiO2nanoparticles dosage. The DAO quality was based on the asphaltene and sulfur contents, API gravity, distillable fraction, and rheological properties. The improvement of the process from the use of nanoparticles was confirmed with important reductions in the asphaltene and sulfur contents in the DAO of up to 24% and 23%, respectively, in comparison with the SDA process. Also, the API gravity can be increased by approximately 14% with thee-SDA process. The rheological properties of the DAO were improved by the inclusion of nanoparticles showing reductions in the viscosities of the DAO greater than 50% in comparison with the conventional process. These results lead to the conclusion that thee-SDA process improves the DAO quality when compared with the typical deasphalting process.