Pipecolic acid enhances resistance to bacterial infection and primes salicylic acid and nicotine accumulation in tobacco

Vogel-Adghough, Drissia; Stahl, Elia; Návarová, Hana; Zeier, Juergen

doi:10.4161/psb.26366

Cited by 70 publications

(65 citation statements)

References 57 publications

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“…Higher level of pipecolic acid in susceptible line observed in this study can be inconsistent with a study reported by Vogel-Adghough et al (2013) that pipecolic acid involved in resistance mechanism in plants after infected by biotrophic pathogen. Probably, the differences between biotrophic and necrotrophic pathogens affect on the pattern of pipecolic acid accumulation and its role in resistance mechanisms.…”

Section: Phenol Involvement In Rice Lines and R Solani Interactioncontrasting

confidence: 99%

Metabolite profiling of sheath blight disease resistance in rice: in the case of positive ion mode analysis by CE/TOF-MS

Suharti

Nose

Zheng

2016

Plant Production Science

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Rice sheath blight is an important disease caused by Rhizoctonia solani. The resistant and susceptible rice lines (32R and 29S, respectively) showed different responses to R. solani infection in metabolite levels. The aim of this study was to characterize the metabolite levels in rice lines during R. solani infection using capillary electrophoresis equipped with time of flight mass spectrophotometry (CE/TOF-MS) in positive ion mode. Hundred metabolites were identified and classified into six clusters by hierarchical cluster using Mass Profiler Professional software. Changes in metabolite level at inoculated 32R and 29S were mapped on branches of tricarboxylic acid and glycolysis pathway. Volcano plot successfully filtered the metabolites based on fold change and p-value. The volcano plot result showed that 10 metabolites were up and down regulated in inoculated 32R relative to 29S. One metabolite, chlorogenic acid, showed a positive response in 32R. Meanwhile, pipecolic acid showed as the highest magnitude of fold change and p-value significance level in 29S. In addition, eight amino acids; glutamate, γ-aminobutyric acid, glycine, histidine, phenylalanine, serine, tryptophan, and tyrosine showed increase in 29S after R. solani inoculation.

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Section: Phenol Involvement In Rice Lines and R Solani Interactioncontrasting

confidence: 99%

Metabolite profiling of sheath blight disease resistance in rice: in the case of positive ion mode analysis by CE/TOF-MS

Suharti

Nose

Zheng

2016

Plant Production Science

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“…Pip amplifies pathogeninduced signals and promotes plants to a primed state to ensure effective activation of defense responses (Návarová et al, 2012;Vogel-Adghough et al, 2013). Pip-mediated SAR induction and defense priming thereby occur by signaling mechanisms that have both SA-dependent and SA-independent characteristics (Bernsdorff et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…More recently, our own studies have revealed that the Lys-derived nonprotein amino acid pipecolic acid (Pip) acts as a crucial regulator of plant SAR (Návarová et al, 2012;Vogel-Adghough et al, 2013;Zeier, 2013;Bernsdorff et al, 2016). Upon inoculation of Arabidopsis with the hemibiotrophic bacterial pathogen Pseudomonas syringae, Pip accumulates to high levels in the inoculated leaves and to considerable amounts also in leaves distal from the site of attack (Návarová et al, 2012).…”

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confidence: 99%

Biochemical Principles and Functional Aspects of Pipecolic Acid Biosynthesis in Plant Immunity

et al. 2017

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The nonprotein amino acid pipecolic acid (Pip) regulates plant systemic acquired resistance and basal immunity to bacterial pathogen infection. In Arabidopsis (Arabidopsis thaliana), the lysine (Lys) aminotransferase AGD2-LIKE DEFENSE RESPONSE PROTEIN1 (ALD1) mediates the pathogen-induced accumulation of Pip in inoculated and distal leaf tissue. Here, we show that ALD1 transfers the a-amino group of L-Lys to acceptor oxoacids. Combined mass spectrometric and infrared spectroscopic analyses of in vitro assays and plant extracts indicate that the final product of the ALD1-catalyzed reaction is enaminic 2,3-dehydropipecolic acid (DP), whose formation involves consecutive transamination, cyclization, and isomerization steps. Besides L-Lys, recombinant ALD1 transaminates L-methionine, L-leucine, diaminopimelate, and several other amino acids to generate oxoacids or derived products in vitro. However, detailed in planta analyses suggest that the biosynthesis of 2,3-DP from L-Lys is the major in vivo function of ALD1. Since ald1 mutant plants are able to convert exogenous 2,3-DP into Pip, their Pip deficiency relies on the inability to form the 2,3-DP intermediate. The Arabidopsis reductase ornithine cyclodeaminase/m-crystallin, alias SYSTEMIC ACQUIRED RESISTANCE-DEFICIENT4 (SARD4), converts ALD1-generated 2,3-DP into Pip in vitro. SARD4 significantly contributes to the production of Pip in pathogen-inoculated leaves but is not the exclusive reducing enzyme involved in Pip biosynthesis. Functional SARD4 is required for proper basal immunity to the bacterial pathogen Pseudomonas syringae. Although SARD4 knockout plants show greatly reduced accumulation of Pip in leaves distal to P. syringae inoculation, they display a considerable systemic acquired resistance response. This suggests a triggering function of locally accumulating Pip for systemic resistance induction.

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“…is now considered a key process in various types of systemic plant immunity (19,20,21,22,97). These defense-priming processes include systemic acquired resistance (SAR) (7,30,50,61,82,118,133), which is induced by necrotizing pathogens and requires salicylic acid (SA) (30,118,133) and pipecolic acid (PA) (82,134). They also comprise induced systemic resistance (ISR) (21,22,96,97), which is activated by growth-promoting bacteria and fungi in the rhizosphere and depends on jasmonate ( JA) and ethylene (ET) (95,97).…”

Section: The Different Meanings Of Primingmentioning

confidence: 99%

Priming for Enhanced Defense

Conrath

Beckers

Langenbach

et al. 2015

Annu. Rev. Phytopathol.

770

648

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When plants recognize potential opponents, invading pathogens, wound signals, or abiotic stress, they often switch to a primed state of enhanced defense. However, defense priming can also be induced by some natural or synthetic chemicals. In the primed state, plants respond to biotic and abiotic stress with faster and stronger activation of defense, and this is often linked to immunity and abiotic stress tolerance. This review covers recent advances in disclosing molecular mechanisms of priming. These include elevated levels of pattern-recognition receptors and dormant signaling enzymes, transcription factor HsfB1 activity, and alterations in chromatin state. They also comprise the identification of aspartyl-tRNA synthetase as a receptor of the priming activator β-aminobutyric acid. The article also illustrates the inheritance of priming, exemplifies the role of recently identified priming activators azelaic and pipecolic acid, elaborates on the similarity to defense priming in mammals, and discusses the potential of defense priming in agriculture.

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Pipecolic acid enhances resistance to bacterial infection and primes salicylic acid and nicotine accumulation in tobacco

Cited by 70 publications

References 57 publications

Metabolite profiling of sheath blight disease resistance in rice: in the case of positive ion mode analysis by CE/TOF-MS

Metabolite profiling of sheath blight disease resistance in rice: in the case of positive ion mode analysis by CE/TOF-MS

Biochemical Principles and Functional Aspects of Pipecolic Acid Biosynthesis in Plant Immunity

Priming for Enhanced Defense

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