PIP-Seq identifies novel heterogeneous lung innate lymphocyte population activation after combustion product exposure
Yung-An Huang,
Xinyu Wang,
Jong-Chan Kim
et al.
Abstract:Innate lymphoid cells (ILCs) are a heterogeneous population that play diverse roles in airway inflammation after exposure to allergens and infections. However, how ILCs respond after exposure to environmental toxins is not well understood. Here we show a novel method for studying the heterogeneity of rare lung ILC populations by magnetic enrichment for lung ILCs followed by particle-templated instant partition sequencing (PIP-seq). Using this method, we were able to identify novel group 1 and group 2 ILC subse… Show more
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