2016
DOI: 10.1016/j.urology.2015.12.021
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Pioglitazone Enhances Survival and Regeneration of Pelvic Ganglion Neurons After Cavernosal Nerve Injury

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Cited by 9 publications
(13 citation statements)
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“…nNOS-positive nerve fibers innervating the penis derive mainly from the MPG [ 23 ]. Our results showed that the nNOS content in both the MPG and the dorsal penile nerve was reduced in the CN traction group, which is consistent with results in other CN injury models [ 9 , 24 , 25 ]. The number of neurofilament-positive nerve fibers in the dorsal penile nerve also declined, indicating that the axon contents were decreased after CN traction, which is also consistent with previous studies [ 26 , 27 ].…”
Section: Discussionsupporting
confidence: 92%
“…nNOS-positive nerve fibers innervating the penis derive mainly from the MPG [ 23 ]. Our results showed that the nNOS content in both the MPG and the dorsal penile nerve was reduced in the CN traction group, which is consistent with results in other CN injury models [ 9 , 24 , 25 ]. The number of neurofilament-positive nerve fibers in the dorsal penile nerve also declined, indicating that the axon contents were decreased after CN traction, which is also consistent with previous studies [ 26 , 27 ].…”
Section: Discussionsupporting
confidence: 92%
“…Pioglitazone appears to preserve erectile activity when the corporal cavernosum undergoes neuronal failure. This was demonstrated in rats with bilateral cavernosal nerve crush injury [ 124 ]. In particular, when pioglitazone was administered both pre- and post-surgically, both survival and regeneration responses within the neuronal pelvic compartment were activated with an increase in nitrergic penis-projecting neurons and upregulation of key neuroprotective molecules (e.g., neurotrophin, neuturin) [ 124 ].…”
Section: Glucose-lowering Medicationsmentioning
confidence: 97%
“…This was demonstrated in rats with bilateral cavernosal nerve crush injury [ 124 ]. In particular, when pioglitazone was administered both pre- and post-surgically, both survival and regeneration responses within the neuronal pelvic compartment were activated with an increase in nitrergic penis-projecting neurons and upregulation of key neuroprotective molecules (e.g., neurotrophin, neuturin) [ 124 ]. Currently, the mechanism underlying these effects are still poorly investigated, even though some studies have established that the prevention of erectile failure by pioglitazone administration could occur via both anti-inflammatory and insulin-like growth factor I (IGF-I)-mediated pathways.…”
Section: Glucose-lowering Medicationsmentioning
confidence: 97%
“…Furthermore, a small randomized controlled trial has shown efficacy of this agent for erectile dysfunction refractory to sildenafil [146]. A study by Katz et al investigated the impact of pioglitazone on pelvic ganglion neurons after bilateral cavernosal nerve injury (BCNI) in Sprague-Dawley rats [147]. Four groups were examined: sham surgery, BCNI, BCNI + post-operative pioglitazone, BCNI + pre-and post-operative therapy.…”
Section: Neuroprotective Agentsmentioning
confidence: 99%
“…Four groups were examined: sham surgery, BCNI, BCNI + post-operative pioglitazone, BCNI + pre-and post-operative therapy. Gene expression profiles of neuronal nitric oxide synthase, neurturin, glial cell line-derived neurotrophic factor family receptor alpha-2 (GFRα2), and β-III tubulin were upregulated in the pre-operative therapy group [147]. Further work is necessary to fully explore the utility of this therapy.…”
Section: Neuroprotective Agentsmentioning
confidence: 99%